Since congenital clubfoot is not a single or uniform entity, one cannot expect a consistently favorable response from a single or uniform method. And one person's ideas or methods of therapy either conservative or operative would be noted insufficient or not applicable to all cases. This report is based upon analysis of records for 44patients seen at National Medical Center from 1971 to 1980. 44 patients with 68 congenital clubfood were seen at the Outpatient Department and 26 in-patients with 40 congenital clubfoot were treated, and the average follow-up period was II. 6 months. If the clubfoot was found early conservative method was applied initially whether it was the flexible or rigid type, and surgery was applied in children whose deformith had not responded to conservative treatment or had been neglected for a long time and proved to be rigid. The results were as follows, 1. Among 68 clubfoot, equinovarus was 64, and calcaneovalgus was 4. Of the 44 patients, 32 were male and 12 were female (2.7:1). 2.Bilaterat involvement was in 24 and unilateral in 20 patients. 3. 35 cases(79. 5%) were idiopathic, and 9 were associated with other congenital abnormalities. Of 40 clubfoot, supple type were 24 feet. and rigid type were 16 feet. In patients under 3 months of age, conservative treatment was found to be quite adequate to obtain good result. 5. 24 feet were treated with a serial cast for the average period of 8 weeks, with the result of 18 good, 3 fair, and 3 poor. To obtain good result, patient's tolerance, parent's eooperation and doctor's skill were all necessary. 6. 18 feet graded good had T-C index of more than 47. Surgical correction was applied in l6 feet of rigid type with the result of 10 good, 2 fair, and 2 poor. Various surgical methods were to be applied according to the age of patients and the main pathology. 8. Modified Turco operation was performed ia 8 patients(6 feet) at the age of 6 months, 8 months and 10 months respectively, and this one stage posteromedial release with K-wire fixation showed the best results in those age groups.
Child ; Clothing ; Clubfoot ; Congenital Abnormalities ; Female ; Follow-Up Studies ; Foot ; Humans ; Male ; Methods ; Outpatients ; Pathology

We reported a case of epidermodysplasia verruciformis which occurred in a 15 year-old girl. She had an extensive eruption of plane warts on the face, neck, upper trunk, and extremities, especially on the dorsa of the hands and feet, with symmetrical diatribution. The skin lesions appeared initially on the forehead and gradually generalized. all over the body for 10 years duration. Skin biopsy showed hyperkeratosis with basket-weave pattern, thickened granular layer, vacuolization of many celIs in the upper stratum malpighii and the granular layer and acanthosis.
Adolescent ; Biopsy ; Epidermodysplasia Verruciformis* ; Extremities ; Female ; Foot ; Forehead ; Hand ; Humans ; Neck ; Skin ; Warts

Pyoderma gangrenosum, as described by Brunsting and his aaaociates in 1930, is characterized by the rapid appearance of one or more bluish-black, boggy, undermined ulcers, most frequently on the legs of peraons with ulcerative colitis or rheumatoid arthritis. Its pathogenesis is often obscure. Present management of pyoderma gangrenosum consists of local treatment of the wound, systemic cortieosteroid therapy, and treatment of any underlying disease. In our 21 year-old male with pyoderma gangrenosum, hyperbaric oxygen therapy was performed. Treatment was given in the hyperbaric oxygen one-man chamber at 3.0 ATA for 30 minutes daily for 49 days. By 36 days, the ulcers on the face and neck was healed. Approximately one month after the patient was discharged, complete resolution of the 1esions on the back occurred.
Arthritis, Rheumatoid ; Colitis, Ulcerative ; Humans ; Hyperbaric Oxygenation* ; Leg ; Male ; Neck ; Oxygen ; Pyoderma Gangrenosum* ; Pyoderma* ; Ulcer ; Wounds and Injuries ; Young Adult

A case of solitary painful glomus tumor occurring in a 36-year-old Korean rnale is reported. This tumor was a slightly elevated, bluish subcutaneous nodule about 1cm. in diameter on the left antecubital fossa. We performed a complete surgical excision of the nodule, which was histopathologically cnnfirmed as a typical solitary glomus tumor.
Adult ; Glomus Tumor* ; Humans

BACKGROUND: Alpha hydroxy acids (AHAs) are known to diminish corneocyte cohesion at the innermost levels of the stratum corneum and have been used in the treatment of various disorders of keratinization. However, their effect on skin barrier function and their irritant potential is not fully understood. OBJECTIVE: Our study was done to evaluate the skin irritancy of AHAs in normal human skin. METHODS: Patches with 1%, 5% and 10% solutions of lactic acid (LA) and glycolic acid (GA) were applied to the volar forearm of 20 healthy volunteers for 24 hours using large Finn chambers with filter paper. Visual scores, erythema (E-) index and transepidermal water loss (TEWL) were measured at 30 min, 24 h and 48 h after removal of the patches. RESULTS: The results are summarized as follows. 1. Visual scores were 0.1+/-0.3 (1%), 0.5+/-0.6 (5%) and 1.1+/-0.8 (10%) at 24 h after removal of LA, and were 0.2+/-0.4 (1%), 0.6+/-0.6 (5%) and 1.0+/-0.7 (10%) at 24 h after removal of GA. They were increased in proportion to the concentrations and there were significant differences in skin responses between the control and each concentration of the solutions. 2. E-indices were 9.1+/-2.1 (control), 8.8+/-1.8 (1%), 9.0+/-2.6 (5%) and 10.5+/-3.9 (10%) at 24 h after removal of LA, and were 9.4+/-1.8 (control), 9.3+/-2.3 (1%), 10.0+/-3.0 (5%) and 11.1+/-3.5 (10%) at 24 h after removal of GA. They were not increased in the patch areas of 1% and 5% solutions in both the LA and GA group, but were significantly increased in the patch areas of 10% solutions in both the LA and GA group. 3. TEWL values were 7.3+/-2.3 (control), 8.3+/-4.0 (1%), 9.8+/-4.5 (5%) and 16.7+/-9.1 (10%) at 24 h after removal of LA, and were 8.1+/-3.2 (control), 7.8+/-3.8 (1%), 8.6+/-3.0 (5%) and 10.9+/-4.1 (10%) at 24 h after removal of GA. They were not increased in the patch areas of 1% LA, 1% GA and 5% LA, but there were high significant differences between the controls and 10% solutions of both LA and GA. CONCLUSION: Visual scores were increased in all concentrations of AHAs tested, but the increase in E-index and TEWL values were not significant or minimal in 1% and 5% solutions of AHAs. These findings suggest that AHAs could be classified as non-corrosive irritants.
Erythema ; Forearm ; Healthy Volunteers ; Humans* ; Hydroxy Acids* ; Irritants ; Lactic Acid ; Skin*

In a large proportion of patients with chronic urticaria, at present, the definite tiology can't be found. There have been occasional attempts to identify the aIIergic causes uaing allergic skin tests, only ta suggest the Candicla albicans and. some food yeasts ae probabIe causes. Thia atady was designed to investgate how often patients with chronic urticaria from Chonnam Province react positively to skin tests with extracts of 42 common. allergene in the standard group Al-13 produced by Bencard Ltd. in England. The authora alao surveyed the clinical characteristics of 63 patients with chronic urtimria of more than 3 months duration, who bad visited the skin clinic of Chosun Univeresity HcepitaI from May. 1977 throug 3. Apr. 1979. The results were summarized as follows; 1. Among 63 patients, the maIe to female ratio was 1: l.2, and the peak incidence was in the 20s and 30s. 2, In regard to the duration of chroic urticaria, the highst frequency waa below one year duration. 3. Among 60s of the pa,tients who experienced seasonal changes, 32.4% had suffered aggravation during the winter. 4. The most common diseases combined with chronic urticaria were allergic rhinitis and atopic dermatitis, occuring in 9.5% of all subjects. 5. Of thase examined, 69.8% showed positive reactions to the prick test with the peak incidence in the 20s and 30s. 6. Among 42 allergens used far the prick test, 28 allergens turned out to be possibly casal agents, the rnost frequent group of allergens involved were grain du sts (27.1%), animal hairs(21.8%) and moulds(16.5%) in that order of frequency and occupying over 65% of the total positive reactions. And the most frequently involved specific allergens were hay dust, mixed grain dust straw dust and tree in that order of frequency. Moreover, 90 of the involved allergens were inhalants. 7. In teen-agers, the reactions to grain dusts, animal ha.irs, rnoulds and pollens were the rnost frequent while reactions to food allergens were most frequent in the 20s, and cotton and house dust are most frequently involved in tbe 40s. 8. Multiple sensitivity was not:d in a majority of cases and the most frequent combination was 2 to 5 allergens. 9. The rnost common abnormal hematologic finding in chronic urticaria was eosinophilia.
Allergens ; Animals ; Edible Grain ; Dermatitis, Atopic ; Dust ; England ; Eosinophilia ; Female ; Humans ; Incidence ; Jeollanam-do ; Pollen ; Rhinitis ; Seasons ; Skin ; Skin Tests ; Urticaria* ; Yeasts

We herein report a case of therapy-resistant dermatomyositis treated with oral prednisolone and chlorambucil combination therapy. Concurrently, she showed cervical carcinoma in situ(CIS). Initially, we started to treat her with combination oral prednisolone, intramuscular methotrexate, hydroxychloroquin, and removal of cervical CIS. However, our patient failed to respond to these regimens. Thus, we had have another combination treatment of oral prednisolone and chlorambucil. After the treatment of this combination regimen, her recalcitrant dermatomyositis improved dramatically without recurrence. There were no significant adverse side effects with chlorambucil therapy.
Chlorambucil* ; Dermatomyositis* ; Humans ; Methotrexate ; Prednisolone ; Recurrence

The peripheral blood eosinophil and serum IgE level in 53 patients with atopic dermatitis (AD) were measured. The patients were divided into 2 groups by severity(mild and severe grous) and into 3 groups by the associated respiratory atopic deseases and/or their family history : respiratory group(patient, with both AD and respiratory atopy), family history group (patient with both AD and family history of respiratory atopy), and atopic group(patient with neither respiratory atopy nor family history of respiratorv atopy). We designed to study which factors are important in the elevation of serum IgE and peripheral blood eosinophil level in AD, and to know possible relationships between the serum eosinophil and IgE level and the several groups of AD. The results are as follows : 1. Peripheral eosinophil counts were higher in severe group(224.8/mm) than in mild group (180.0/mm)(p<0.05). 2. Peripheral eosinophil counts were 220.0/mm in atopic group, l65.0/mm in family history group, and 332.4/mm in respiratory group, but there was no stitistically significant difference among 3 groups. This suggests that concomitant respiatitiry atopy or a family history of respiratory atopy is not an important factor in the elvation of peripheral blood eosinophil counts in AD. 3. Serum IgE was higher in severe group(443.2IU/ml) than in mild group(231.5IU/ml)(p<0.05). 4. Serum IgE level in respiratory group(754.6IU/ml) were signifiiantlly higher than in atopic (286.6IU/ml) or family history group(342.0IU/ml)(p<0,01). But there was no significant. difference between family and atopic group. This result suggests that concomittent respiratory atopy is a potential factor in elevation of serurn Igi in AD. 5. Slightly high correlation between peripheral blood and IgE level appeared in all 53 patients (r=0.434) and severe group(r=0.480). But, respiratory group(r=0.060), family history group(r=0.111) and atopic group(r=0.202) showed poor relationships.
Dermatitis, Atopic* ; Eosinophils* ; Humans ; Immunoglobulin E*

No abstract available.
Colonic Neoplasms* ; Rectum*

Clear cell hidradenoma, generally as an eccrine sweat gland origin, is a fairly uncommon tumor and occurs as a slowly growing, usually solitary nodule. The histological patterns vary from one tumor to another and in different parts of the same tumor. We experienced three cases of clear cell hidradenoma which were diagnosed by the histopathologic examination of the tumor mass removed by surgical excision. Clinical and histopathologic features of each case were reviewed and compared.
Acrospiroma* ; Sweat Glands