Purpose: We used spectral domain optical coherence tomography (SD-OCT) to assess the retinal and choroidal thicknesses of the rabbit, a commonly used animal model of ophthalmic disease. We report normative datasets. Methods: Semi-automated measurements were made on 15 normal right eyes of New Zealand white rabbits. Total retinal, inner retinal layer, outer retinal layer, choroidal, ganglion cell layer, ganglion cell complex, inner nuclear layer, and outer nuclear layer thicknesses were measured at fixed distances (0, 1, 2, 3, 4, and 5 mm) below the optic nerve head. Results: Total retinal layer (Pearson’s correlation coefficient [CC] = -0.778, p < 0.05), inner retinal layer (CC = -0.710, p < 0.05), outer retinal layer (CC = -0.495, p < 0.05), ganglion cell complex (CC = -0.292, p < 0.05), ganglion cell layer (CC = -0.284, p < 0.05), and outer nuclear layer thicknesses (CC = -0.760, p < 0.05) decreased with the distance from the optic nerve head. Inner nuclear layer thickness correlated negatively with the distance from the optic nerve head, but the correlation coefficient was low (CC = -0.263, p < 0.05). Choroidal thickness increased with the distance from the optic nerve head (CC = 0.511, p < 0.05). Conclusions Rabbit retinal thicknesses were measured and analyzed by the distance from the optic nerve head. The datasets will serve as standards when using rabbits.

Purpose: We used spectral domain optical coherence tomography (SD-OCT) to assess the retinal and choroidal thicknesses of the rabbit, a commonly used animal model of ophthalmic disease. We report normative datasets. Methods: Semi-automated measurements were made on 15 normal right eyes of New Zealand white rabbits. Total retinal, inner retinal layer, outer retinal layer, choroidal, ganglion cell layer, ganglion cell complex, inner nuclear layer, and outer nuclear layer thicknesses were measured at fixed distances (0, 1, 2, 3, 4, and 5 mm) below the optic nerve head. Results: Total retinal layer (Pearson’s correlation coefficient [CC] = -0.778, p < 0.05), inner retinal layer (CC = -0.710, p < 0.05), outer retinal layer (CC = -0.495, p < 0.05), ganglion cell complex (CC = -0.292, p < 0.05), ganglion cell layer (CC = -0.284, p < 0.05), and outer nuclear layer thicknesses (CC = -0.760, p < 0.05) decreased with the distance from the optic nerve head. Inner nuclear layer thickness correlated negatively with the distance from the optic nerve head, but the correlation coefficient was low (CC = -0.263, p < 0.05). Choroidal thickness increased with the distance from the optic nerve head (CC = 0.511, p < 0.05). Conclusions Rabbit retinal thicknesses were measured and analyzed by the distance from the optic nerve head. The datasets will serve as standards when using rabbits.

BACKGROUND: Family values of a married woman may be related to her own depressive mood. Since depressive mood of a married woman is likely to exert a negative influence, in terms of mental health, on her, her family members, and the whole society's, it may be very important to explore the relationship between family values in married women and their depressive mood. METHODS: In this study, we analyzed nationally representative 5,818 married women aged 20 years or older from the 4th panel data of 2012 Korean Longitudinal Survey of Women and Families. As for variables of interest, we constructed three family values variables: family-oriented view of marriage, individualistic view of marriage, and traditional view of marital roles. Then we employed multivariate logistic regression analyses to explore the relationship between family values and depressive mood, adjusting for family and socio-demographic factors. RESULTS: In total, 804 married women (18.4%) had experienced depressive mood. All of the three family values variables were significant in their relationships with depressive mood. The women categorized as ‘very weak’ in family-oriented view of marriage were more likely to experience depressive mood than the women categorized as ‘very strong’ (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.53–2.55). By contrast, the women categorized as ‘very weak’ in individualistic view of marriage (OR, 0.43; 95% CI, 0.33–0.55) and in traditional view of marital roles (OR, 0.68; 95% CI, 0.51–0.92) were less likely to experience depressive mood than their respective counterpart women categorized as ‘very strong.’ CONCLUSION: In Korea, married women's values towards marriage itself and roles between wives and husbands had significant associations with their depressive mood. This suggests that in order to improve mental health in married women, we need to take social and cultural dimensions into consideration along with public health interventions.
Depression ; Female ; Humans ; Korea ; Logistic Models ; Longitudinal Studies ; Marriage ; Mental Health ; Public Health ; Spouses

Purpose: To evaluate the clinical outcomes of 25-gauge microincision vitrectomy for vitreoretinal diseases in patients who have undergone glaucoma drainage implant surgery for the treatment of neovascular glaucoma. Methods: We retrospectively examined the preoperative and postoperative best corrected visual acuity (BCVA), intraocular pressure (IOP), and complications of patients with previous Ahmed valve implantation surgery who underwent vitrectomy and were available for follow-up for at least 6 months. Results: A total of 20 eyes had Ahmed valve implantation for neovascular glaucoma, of which 16 eyes (80%) had proliferative diabetic retinopathy, and 4 eyes (20%) had central retinal vein occlusion. All eyes underwent 25-gauge microincision vitrectomy for the treatment of vitreous hemorrhage unresponsive to conservative treatment. BCVA (logarithm of minimal angle of resolution, logMAR) improved from 1.08 ± 0.29 preoperatively to 0.61 ± 0.32 (p = 0.004) postoperatively. Mean IOP increased from 16.2 ± 3.4 mmHg preoperatively to 17.4 ± 2.8 mmHg at 6 months postoperatively (p = 0.569), with no significant change. There were no cases of exposed body or tube of Ahmed valve after surgery, and vitreous hemorrhage (7 eyes, 31.8%) was the most common complication. Conclusions With a carefully chosen incision site, 25-gauge microincision vitrectomy is an effective treatment method to treat vision-threatening complications such as vitreous hemorrhage in eyes previously implanted with a glaucoma drainage device, with minimal impact on elevated intraocular pressure.

Most nonischemic CRVOs present relatively good prognosis in visual acuity and spontaneous resolution is relatively common after a certain period of time, but a small portion convert to ischemic CRVOs. The point of conversion from nonischemia to ischemia ranges from few weeks to several years. But because more than half of these conversions occur within the first four months, it requires careful follow-up during this period. The authors retrospectively reviewed 44 patients(47 eyes)who initially showed definite signs of nonischemic CRVO on fundus examination and nonperfusion area less than 10 disc areas proven by fluorescein angiogra-phy. The conversion rate, point of conversion, incidence of anterior segment neovascularization and neovascular glaucoma, predictive factors related to conversion were identified. The average age of the patients was 46. 1 years and 26 patients(59. 0%) were male. 25 patients(56. 8%)had underlying systemic and ocular disorders such as hypertension, chronic renal failure, diabetes mellitus, primary open-angle glaucoma. Final visual acuity was 0.5 or above in 24 eyes(51. 0%)and 0.1 or below in 14 eyes(29. 8%). 7 eyes(14. 9%)converted to ischemic occlusion. The average age of this group of patients was 40.8 years and 4 eyes had underlying systemic disorders. Initial visual acuity showed wide range from 0.15 to 0.7 but final visual acuity was 0.1 or below in all of the cases. The point of the conversion was less than 4 months(average: 9.3 weeks)in all eyes and 5 eyes(71.4%)developed anterior segment neovascularization. All of the eyes that showed definite evidence of anterior segment neovascularization were treated with panretinal photocoagulation but in 2 eyes(28. 6%), regression of neovascularization did not occur and further developed neovascular glaucoma.
Diabetes Mellitus ; Fluorescein ; Follow-Up Studies ; Glaucoma, Neovascular ; Glaucoma, Open-Angle ; Humans ; Hypertension ; Incidence ; Ischemia ; Kidney Failure, Chronic ; Light Coagulation ; Male ; Prognosis ; Retinal Vein* ; Retrospective Studies ; Visual Acuity

OBJECTIVES: The purpose of this study was to estimate the socioeconomic costs resulting from alcohol drinking among adolescents as of 2006 from a societal perspective. METHODS: The costs were classified into direct costs, indirect costs, and other costs. The direct costs consisted of direct medical costs and direct non-medical costs. The indirect costs were computed by future income losses from premature death, productivity losses from using medical services and reduction of productivity from drinking and hangover. The other costs consisted of property damage, public administrative expenses, and traffic accident compensation. RESULTS: The socioeconomic costs of alcohol drinking among adolescents as of 2006 were estimated to be 387.5 billion won (0.05% of GDP). In the case of the former, the amount included 48.25% for reduction of productivity from drinking and hangover, 39.38% for future income losses from premature death, and 6.71% for hangover costs. CONCLUSIONS: The results showed that the socioeconomic costs of alcohol drinking among adolescents in Korea were a serious as compared with that of the United States. Therefore, the active interventions such as a surveillance system and a prevention program to control adolescents drinking by government and preventive medicine specialist are needed.
Accidents, Traffic/economics ; Adolescent ; Alcohol Drinking/*economics ; Costs and Cost Analysis ; Efficiency ; Health Services/economics/utilization ; Humans ; *Models, Economic ; Republic of Korea ; Socioeconomic Factors

Dermatomyositis (DM) is an idiopathic autoimmune connective disease characterized by muscles and skin inflammation of and a well-recognized association with several human malignancies, especially breast cancer. Paclitaxel is a taxane antineoplastic agent with therapeutic effects against a wide range of cancers including breast cancer. This drug is well known for neurotoxicity and hypersensitivity reactions. However, cutaneous drug eruptions, especially those of grade III or higher, are not frequent. Here, we describe the case of a 55-year-old woman with metastatic breast cancer who developed paraneoplastic DM and a paclitaxel-induced exanthematous drug eruption. This case report emphasizes the importance of evaluating internal malignancies, such as advanced breast cancer, in newly developed DM patients. In addition, it presents a rare case of paclitaxel-induced exanthematous drug eruption. The purpose of this case report highlights the immunological pathogenic mechanism of DM and drug eruption in underlying advanced breast cancer.
Breast Neoplasms* ; Dermatomyositis* ; Drug Eruptions* ; Female ; Humans ; Hypersensitivity ; Inflammation ; Middle Aged ; Muscles ; Paclitaxel ; Skin

Premacular hemorrhage (preretinal,subhyaloid, or sub-internal limiting membrane hemorrhage)impairs central vision abruptly and occurs in various underlying diseases. In cases of persistent hemorrhage, permanent impairment of vision may occur. Proposed therapeutic options for premacular hemorrhage consist of conservative treatment, laser photodisruption and early vitrectomy. Laser photodisruption may be performed in cases of persistent or slow-clearing hemorrhage, in patients with occupational need for prompt restoration of binocular vision or in patients with poor vision in their fellow eyes. The authors report 4 patients with premacular hemorrhage who were treated with Nd: YAG laser photodisruption with the review of the literatures.
Hemorrhage* ; Humans ; Lasers, Solid-State* ; Membranes ; Vision, Binocular ; Vitrectomy

BACKGROUND: Glycemic control is an effective way to reduce the cardiovascular complications of diabetes, but more than half of the adults with diabetes in Korea are improperly controlling their glycemic levels. The purpose of this study is to identify the factors associated with poor glycemic control in type 2 diabetes patients. METHODS: This study analyzed 1,261 subjects ≥30 years old diagnosed with type 2 diabetes who participated in the fifth Korean National Health and Nutrition Examination Survey (2010-2012). Poor glycemic control rates were defined as hemoglobin A1c (HbA1c) level ≥7%. To shed light on the causes of poor glycemic control, socio-demographics, diabetes severity, health status, and health behavior factors were adjusted and logistic regression was done. RESULTS: Of the total 1,261 patients, 53.0% of patients with type 2 diabetes had HbA1c ≥7%. After running a logistic regression model, the odds ratio of poor glycemic control was higher in high school graduates than elementary school graduates; in people living in Chungcheong and Jeolla/Jeju than those living in Seoul; in the group with diabetes for over 5 years had diabetes less than 5 years; in a group with insulin and oral hypoglycemic agent treatment than non-treatment; in a group with hypertriglyceridemia than without hypertriglyceridemia; and in the group with slept less than 6 hours slept 7-8 hours. CONCLUSION: We need a comprehensive public health policy to reduce the poor glycemic control rates in type 2 diabetes patients. We should recognize the education levels, duration of diabetes, diabetes treatment, hypertriglyceridemia, and sleep duration were associated with poor glycemic control.
Adult ; Diabetes Mellitus, Type 2* ; Education ; Health Behavior ; Humans ; Hypertriglyceridemia ; Insulin ; Korea* ; Logistic Models ; Nutrition Surveys* ; Odds Ratio ; Public Health ; Running ; Seoul