2.The Relationship between Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and the Rubella Virus.
Seok Jin CHOI ; Dan A OH ; Woochang CHUN ; Sung Min KIM
Journal of Clinical Neurology 2018;14(4):598-600
No abstract available.
Glycoproteins*
;
Oligodendroglia*
;
Rubella virus*
;
Rubella*
3.Ischemic Stroke Caused by Spontaneous Subclavian Artery Dissection
Woochang CHUN ; Haein BAK ; Sangwon LEE ; Dan A OH ; Cindy W YOON
Journal of the Korean Neurological Association 2018;36(4):393-395
No abstract available.
Stroke
;
Subclavian Artery
4.Cholestasis Causes Discrepancy in HDL-Cholesterol Levels Measured Using Various Methods.
Sollip KIM ; Sail CHUN ; Woochang LEE ; Ghi Su KIM ; Won Ki MIN
Laboratory Medicine Online 2012;2(3):174-178
Herein, we report a case in which cholestasis caused discrepancy in high-density lipoprotein (HDL)-cholesterol levels measured using various methods. The discrepancy in HDL-cholesterol level originated from the abnormal increase in the level of an unusual lipoprotein, apo E-rich HDL, in the patient's serum. An abnormal slow alpha-migrating lipoprotein was observed on agarose gel electrophoresis, and an abnormal large-sized HDL was observed in a lipoprotein subfraction study. The level of apolipoprotein E was elevated.
Apolipoproteins
;
Cholestasis
;
Electrophoresis, Agar Gel
;
Lipoproteins
5.Cholestasis Causes Discrepancy in HDL-Cholesterol Levels Measured Using Various Methods.
Sollip KIM ; Sail CHUN ; Woochang LEE ; Ghi Su KIM ; Won Ki MIN
Laboratory Medicine Online 2012;2(3):174-178
Herein, we report a case in which cholestasis caused discrepancy in high-density lipoprotein (HDL)-cholesterol levels measured using various methods. The discrepancy in HDL-cholesterol level originated from the abnormal increase in the level of an unusual lipoprotein, apo E-rich HDL, in the patient's serum. An abnormal slow alpha-migrating lipoprotein was observed on agarose gel electrophoresis, and an abnormal large-sized HDL was observed in a lipoprotein subfraction study. The level of apolipoprotein E was elevated.
Apolipoproteins
;
Cholestasis
;
Electrophoresis, Agar Gel
;
Lipoproteins
6.Performance Evaluation of ADVIA Centaur XPT.
Eun Jung CHO ; Kyoung Jin PARK ; Woochang LEE ; Sail CHUN ; Won Ki MIN
Journal of Laboratory Medicine and Quality Assurance 2017;39(1):47-51
We have evaluated the performance of a recently developed immunoassay analyzer, ADVIA Centaur XPT (Siemens, Germany). Precision, linearity, and comparison studies were performed according to the CLSI guidelines. The test items evaluated were ferritin, folate, human epidermal growth factor receptor 2/neu, homocysteine, vitamin B₁₂, B-type natriuretic peptide, creatine kinase–myocardial band, myoglobin, procalcitonin, troponin I. Bio-Rad control materials, linearity materials, and patients' samples were used for the evaluation. For the correlation study, ADVIA Centaur XP (Siemens) were used as comparative methods. The total coefficients of variations (CVs) of the analytes were between 2.5% and 7.0%. The results of linearity evaluation were also acceptable for the range tested. Correlations with comparative methods were good. The overall analytical performance of ADVIA Centaur XPT is acceptable for the immunology analyzer. Therefore, ADVIA Centaur XPT is expected to be widely used.
Allergy and Immunology
;
Creatine
;
Ferritins
;
Folic Acid
;
Homocysteine
;
Humans
;
Immunoassay
;
Myoglobin
;
Natriuretic Peptide, Brain
;
Receptor, Epidermal Growth Factor
;
Statistics as Topic
;
Troponin I
;
Vitamins
7.Analytical Performance Evaluation of Glucose Monitoring System Following ISO15197.
Dongheui AN ; Hee Jung CHUNG ; Hye Won LEE ; Woochang LEE ; Sail CHUN ; Won Ki MIN
The Korean Journal of Laboratory Medicine 2009;29(5):423-429
BACKGROUND: We have evaluated the analytical performance of SureStep Flexx (Johnson and Johnson, USA) which can report the plasma equivalent glucose test results and be connected to the hospital information networks, following ISO15197 analytic procedure for glucometer for the first time. METHODS: Adopting the guidelines of ISO15197, we measured the precision of ten glucometers from their repeatability and intermediate precision, and determined the accuracies of the glucometer, comparing to those of GEM Premier 4000 (Instrumentation Laboratory, USA). In addition, the guidelines of CLSI EP9-A2 and EP6-A were applied to correlate between data of glucometer and those of laboratory reference method by TBA-200FR (Toshiba Medical Systems, Japan) and to examine its linearity of glucose concentrations measured by SureStep Flexx. We used the clinical specimens and commercial control materials. RESULTS: Repeatabilities and intermediate precisions of those glucometers were 4.0-7.3%, and 4.3-6.2%, respectively. When glucose levels are under 75 mg/dL, the difference between results of those meters and the reference values were within +/-6 mg/dL. However when glucose levels are over 75 mg/dL, those differences were within +/-12.7%. These results were acceptable for the ISO15197 criteria in all glucose concentrations. The glucose concentrations showed the clinically relevant linearity in the range from 36 mg/dL to 491 mg/dL. Moreover, Error Grid Analysis showed that all glucose results were in "zone A", which means that these values were clinically accurate. CONCLUSIONS: This study showed that SureStep Flexx can provide reliable results for patients and clinicians to manage the diabetes mellitus, satisfying the ISO15197 criteria.
Blood Glucose/*analysis
;
Blood Glucose Self-Monitoring/*instrumentation/methods/*standards
;
Diabetes Mellitus/blood/diagnosis
;
Humans
;
Quality Control
;
Reference Values
;
Reproducibility of Results
8.Development and Evaluation of a Laboratory Information System-Based Auto-Dilution and Manual Dilution Algorithm for Alpha-Fetoprotein Assay.
Tae Dong JEONG ; So Young KIM ; Woochang LEE ; Sail CHUN ; Won Ki MIN
Annals of Laboratory Medicine 2013;33(5):390-392
No abstract available.
*Algorithms
;
Automation
;
Clinical Laboratory Information Systems/*standards
;
Humans
;
Immunoassay/*methods
;
Indicator Dilution Techniques
;
alpha-Fetoproteins/*analysis
9.Evaluation of the Blood Gas Analyzer GEM Premier 4000.
Hee Young CHUNG ; Hee Jung CHUNG ; Sail CHUN ; Woochang LEE ; Won Ki MIN
Journal of Laboratory Medicine and Quality Assurance 2009;31(1):207-214
BACKGROUND: We evaluated the performance of the GEM Premier 4000 (Instrumentation Laboratory, USA), a new blood gas/electrolytes/co-oximetry analyzer, according to the Clinical and Laboratory Standard Institute (CLSI) guidelines. METHODS: Within-run precision, total-run precision, linearity and sample-related carryover were analyzed using quality control materials at three different concentration levels for each analytes. Correlation was compared with the routinely used NOVA CCX2 (Nova Biomedical, USA) with patients' whole blood samples. RESULTS: The within-run and the total-run precisions of the GEM Premier 4000 showed very low CV of 0.04~4.40% and 0.06~4.11%, respectively, in all parameters except the lactate, which had CV of 5.58% in Level 1 QC material. The system showed a good linearity (r2=0.997~1.000, systemic error=0.00~0.20%) for all items. Sample-related carryover was -4.35%~0.15%. In comparison with the NOVA CCX2 instrument, correlation was high in all parameters with the r value ranging from 0.983-0.999 except for carboxyhemoglobin (r=0.804) and methemoglobin (r=0.010) whose concentrations were in the lower level. CONCLUSIONS: GEM Premier 4000 showed good analytical performance required for blood gas analyzer in its precision, linearity, sample-related carryover, and close correlation with NOVA CCX2. It fulfills most of the requirements for both point-of-care and laboratory use.
Carboxyhemoglobin
;
Lactic Acid
;
Methemoglobin
;
Quality Control
10.Therapeutic Drug Monitoring of Tacrolimus and Sirolimus.
Sail CHUN ; Woochang LEE ; Won Ki MIN
Journal of Laboratory Medicine and Quality Assurance 2008;30(2):241-242
No abstract available.
Drug Monitoring
;
Sirolimus
;
Tacrolimus