BACKGROUND: Restenosis remains one of major clinical problems in the coronary intervention. The effects of local radiation using radioactive balloon loaded with Ho-166 on coronary restenosis in the porcine model were observed. METHODS: Overdilation injury was performed in porcine coronary arteries using control balloon [Group I, n=, left anterior descending artery (LAD)=, left circumflex artery (LCX)=, right coronary artery (RCA)=] and Ho-166 loaded polyurethane-coating balloon [Group II; n=0, 21.98.1 mCi (20 Gy at 0.5 mm in depth), LAD=, LCX=, RCA=] at 5 atm for 3 min. Follow-up quantitative coronary angiogram (QCA) and histopathologic findings were compared at 4 weeks after balloon injury between two groups. RESULTS: Acute or late thrombotic arterial occlusion was not observed in both groups. Diameter stenosis measured by QCA was not different between two groups (Group I: 11.61.6%, II: 7.68.4%, P=.44). On histopathologic study, injury score, external and internal elastic lamina area, and media area were not different between two groups. Neointimal area and histopathologic area stenosis were significantly higher in Group I (0.320.86mm2, 20.677.01%) than those of Group II (0.150.26mm2, 12.032.44%). By immunocytochemistry, proliferating cell nuclear antigen indices in neointima and media were 8.244.44%, 7.972.46% in Group I, and 7.172.25%, 5.471.44% in Group II, which were not different between two groups(P=.587, 0.089). CONCLUSION: Local radiation using Ho-166 balloon is effective in reducing neointimal proliferation in a porcine model.
Arteries ; Constriction, Pathologic ; Coronary Restenosis* ; Coronary Vessels ; Follow-Up Studies ; Immunohistochemistry ; Neointima ; Proliferating Cell Nuclear Antigen

During the summer season(July-August) in 1967, the insecticide tests for resistance on adult A. sinensis and C. tritaeniorhynchus were carried out in Gobu-Myun Jeongup-Gun, Chollapuk-Do, where many Japanese encephalitis cases occur every year. The mortality by 4.0% DDT in A. sinensis was 88.9% and by 4.0% dieldrin was 84.4%. Therefore the LC-50 of DDT for A. sinensis was 1.75%, while LC-50 of dieldrin was 1.1%. The mortality by 4.0% DDT in C. tritaeniorhynchus was 36.7%, and by 4.0% dieldrin was 6.0% The result indicates that A. sinensis in Korea is susceptible to DDT and resistant to dieldrin. C. tritaeniorhynchus is highly resistant to both DDT and dieldrin.
parasitology-arthropoda ; vector ; mosquito ; Culex tritaeniorhynchus ; Anopheles sinensis ; chemotherapy ; DDT ; dieldrin

Immunologic or immunopathologic assays are neccesary for the diagnosis of autoimmune bullous dermatoses including pemphigus vulgaris (PV), bullous pemphigoid (BP), and epidermolysis bullosa acquisita (EBA). The objectives of this study is to compare the sensitivity and usefulness of indirect immunofluorescence 0F) with that of immunoblot assay using amplified alkaline phosphatase staining system in the diagnosis of the above diseases; detection of disease-specific IgG autoantibodies. We selected 4 patients in each bullous dermatosis of PV, BP, and EBA, who had serum levels of IgG autoantibodies at a titer of 1:80 or higher. In each three disease, 2 patients with negative serum antibodies or serum titer lower than 1:20, were also enrolled. Among the former 4-patient groups the titers of IgG antibodies found on indirect IF were in the range of 1:80 to 1:160, whereas the titers recognized by immunoblot assay were 1 or 2 dilutions higher in most of these patients. In the latter 2-patient groups, 4 out of the 6 cases revealed antibody-positive on immunoblot-staining membrane. The indirect IF can be performed easily and seems favorable in the aspect of cost-effectiveness. However, immunoblot assay with sensitive staining method would be warranted in cases of antibody-negative or atypical clinical variants of autoimmunebullous dermatoses to confirm the diagnosis.
Alkaline Phosphatase ; Antibodies ; Autoantibodies ; Diagnosis ; Epidermolysis Bullosa Acquisita ; Fluorescent Antibody Technique, Indirect ; Humans ; Immunoglobulin G ; Membranes ; Pemphigoid, Bullous ; Pemphigus ; Skin Diseases ; Skin Diseases, Vesiculobullous*

One case of tuberculosis verrucosa cutis associated with inguinal lymphnode enlargement is presented. The patient, 24 years old male, has had palm-sized, dark-brown colored, indurated verrucous patch on left buttoek since 12 years old. Diagnosis was confirmed by characteristic clinical appearance, laboratory findings and histopathology. So he has been treated with I.N.A.H., P.A.S., streptomycin and pyridoxine. Remarkable effect was observed.
Child ; Diagnosis ; Humans ; Male ; Pyridoxine ; Streptomycin ; Tuberculosis* ; Young Adult

Due to the limited availability of immunoelectron microscopy, an alternative method for the differentiation between anti-lamina lucida and anti-sublamina densa antibodies was introduced; indirect immunofluorescence using NaCl-treated human skin as the substrate. In this study author examined sera and lesional skin of 4 cases of bullous pemphigoid (BP), and 2 cases of epidermolysis bulloaa acquisita(EBA) with the above mentioned indirect imrnunofluorescence and modified direct immunofluorescence to evaluate the specificity of the tests. The results showed that in BP the fluorescence patterns were epidermal in 3 patients with 1 combined by indirect immunofluorescence, and epidermal in all 4 patients by modified direct immunofluorescence. In ERA the fluorescence were dermal patterns in both 2 patients by indirect and modified direct immunofluorescence. These data are further confirming the syecificity and the reproducibility of the NaCl extraction technique for the irnmunofluorescence to differentiate the localization of the autoantibodies in the above two bullous dermatoses.
Antibodies ; Autoantibodies ; Epidermolysis Bullosa Acquisita* ; Epidermolysis Bullosa* ; Fluorescence ; Fluorescent Antibody Technique ; Fluorescent Antibody Technique, Direct ; Fluorescent Antibody Technique, Indirect ; Humans ; Microscopy, Immunoelectron ; Pemphigoid, Bullous* ; Sensitivity and Specificity ; Skin ; Skin Diseases, Vesiculobullous

No abstract available.
Child* ; Humans ; Kidney Transplantation*

No abstract available.
Hyperlipidemias*

One case of Incontinentia pigmenti associated with convulsion has been presented and she has delayed growing and emerciation. The patient who was four months old girl had been affected irregular mesh-like dark brown or chocolate colored pigmentation on both leg (inner surfeee). Diagnosis was confirmed by characteristic clinical appearance, laboratory findings and histopathology.
Cacao ; Diagnosis ; Female ; Humans ; Incontinentia Pigmenti ; Leg ; Pigmentation ; Seizures

No abstract available.
Hypothyroidism*

No abstract available.
Humans ; Infant, Newborn ; Infant, Premature*