A gastric carcinoma is the commonest malignancy in Korea and the purpose of this study is: a. to predict the prognosis of gastric carcinoma patient preoperatively b. to gastrectomize as minimally as possible to reduce postoperative morbidity c. to compare a radiologic findings with an endoscopic, gross and pathologic features. And two representative cases are presented here and the invasion depth and extent of the gastric carcinoma of the stomach is evaluated and discussed with the review of articles.
Humans ; Korea ; Prognosis ; Stomach

No abstract available.
Nipples*

Polyvesicular vitelline tumor of the ovary is an extremely rare variant of yolk sac tumor. We present a case of pure polyvesicular vitelline tumor in a 43-year-old woman. Light microscopy revealed a predominantly polyvesicular pattern embedded in mesoblastic stroma with the cysts showing two type of lining; tall columnar and cuboidal, or mesothelioid cells. The lining atypical cells showed occasional mitoses and intracytoplasmic PAS positive hyaline globules. In some areas, the cystic space contained a large amount of intraluminal hyaline material. Immunohistochemically, alpha- fetoprotein and alpha-1-antitrypsin were detected as a fine granular deposit in the cytoplasm of epithelial cells and hyaline globules. Electron microscopically, marked specialization of the vesicular lining cells suggested a differentiation toward gut structures and mature yolk sac.
Adult ; Cytoplasm ; Endodermal Sinus Tumor ; Epithelial Cells ; Female ; Fetal Proteins ; Humans ; Hyalin ; Microscopy ; Mitosis ; Ovary* ; Vitellins* ; Yolk Sac

Polyvesicular vitelline tumor of the ovary is an extremely rare variant of yolk sac tumor. We present a case of pure polyvesicular vitelline tumor in a 43-year-old woman. Light microscopy revealed a predominantly polyvesicular pattern embedded in mesoblastic stroma with the cysts showing two type of lining; tall columnar and cuboidal, or mesothelioid cells. The lining atypical cells showed occasional mitoses and intracytoplasmic PAS positive hyaline globules. In some areas, the cystic space contained a large amount of intraluminal hyaline material. Immunohistochemically, alpha- fetoprotein and alpha-1-antitrypsin were detected as a fine granular deposit in the cytoplasm of epithelial cells and hyaline globules. Electron microscopically, marked specialization of the vesicular lining cells suggested a differentiation toward gut structures and mature yolk sac.
Adult ; Cytoplasm ; Endodermal Sinus Tumor ; Epithelial Cells ; Female ; Fetal Proteins ; Humans ; Hyalin ; Microscopy ; Mitosis ; Ovary* ; Vitellins* ; Yolk Sac

Migration of the fixation device to a part of the body is well known complication of fracture treatment. However, few reports of this complication have appeared in the literature. The present report concerns two instances of the migration of a K-wire and a Steinmann pin from the acromioclavicular joint, respectively, into the neck. It appears that if wires and pins are used for fixation, the lateral ends should be bent to prevent medial migration, and as soon as the desired therapeutic results have been obtained, these must be subsequently removed.
Acromioclavicular Joint ; Fixatives ; Neck

No abstract available.
Knee*

BACKGROUND: bcl-2 is a newly characterized proto-oncogen that has been shown to suppress programmed cell death(apoptosis), which is involved in tumorigenesis, and its expression has been demonstrated within tumor cells in a variety of neoplasms. OBJECTIVE: We examined whether there are differences in bcl-2 expression in basal cell carcinoma and several epidermal keratinocytic tumors. In addition, we evaluated bcl-2 expression according to histological types of basal cell carcinoma as well as the interaction of expression of bcl-2 and MIB-1 protein in BCC subtypes. METHODS: Routine paraffin sections of formalin-fixed sixty tissues(20 BCC, 10 Bowen disease, 10 keratoacanthoma, and 20 SCC) were labelled with anti-bcl-2 monoclonal antibody and MIB-1 using a labelled streptavidin-biotin complex. RESULTS: 1. Twenty cases of basal cell carcinoma were examined and all expressed cytoplasmic bcl-2. Three out of 20 cases of squamous cell carcinoma were focally positive. None of the 10 Bowen disease cases and the 10 keratoacanthoma cases expressed bcl-2. 2. In BCC, bcl-2 immunoreactivity was great in the superficical subtypes which had an indolent growth variant, moderate in the circumscribed types, and weak in the infiltrative types which had aggressive growth variants. 3. Evaluation of the distribution of bcl-2 immunoreactive categories and MIB-1 grades revealed a negative correlation tendency, but no statistical significance. CONCLUSION: Our results suggest the presence of a protection mechanism from apoptosis mediated by bcl-2 protein involved in the neoplastic growth mechanism of BCC. In addition, the observed findings in the expression pattern of bcl-2 and MIB-1 in the BCC subtypes may be due to interaction between bcl-2 and other apoptotic-related oncogens.
Apoptosis ; Bowen's Disease ; Carcinogenesis ; Carcinogens ; Carcinoma, Basal Cell* ; Carcinoma, Squamous Cell ; Cytoplasm ; Keratoacanthoma ; Ki-67 Antigen ; Paraffin

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

The present study was undertaken to investigate the relationship between serum lipid and lipoprotein values and cerebrovascular accidents. Serum lipids and lipoproteins were measured in 130 cases of normal Korean, 49 patients with cerebrovascular accidents and 35 patients with uncomplicated essential hypertension. The results were summarized as follows; 1. The mean values of serum lipids in patients with cerebrovascular accidents were 148.3+/-75.3mg% for triglyceride, 189.6+/-37.4mg% for cholesterol, 132.5+/-55.2mg% for phospholipid and 548.8+/-106.3mg% for total lipid. 2. The mean values of serum lipoproteins in patients with cerebrovascular accidents were 255.3+/-81.6mg% for beta-lipoprotein, 118.3+/-73.7mg% for pre-beta-lipoprotein and 183.6+/-65.5mg% for alpha-lipoprotein. 3. There were no significant differences of sex and age in the mean values of serum lipids and lipoproteins in patients with cerebrovascular accidents. 4. In general the mean concentrations of serum lipids and lipoproteins, except phospholipid and alpha-lipoprotein, in patients with cerebrovascular accidents and hypertension were significantly elevated than in normal control subjects. 5. There were no significant differences in serum lipid and lipoprotein values between various types of cerebrocasculr accidents. 6. The change of serum lipid and lipoprotein values had a decreasing tendency till one month after onset, thereafter the values became similar to to\hose of early period of illness. 7. The incidence of hyperlipoproteinemia in patients with cerebrovascular accidents was 64%, and the most frequent type of hyperlipoproteinemia was Type IIa, as the frequency decreased in the order of Type IV, Type IIb and Type III.
Cholesterol ; Humans ; Hyperlipoproteinemias ; Hypertension ; Incidence ; Lipoproteins* ; Stroke* ; Triglycerides

A clinical study was made on 434 patients of valvular heart disease admitted to the Seoul National University Hospital during the period of November 1971-February 1978. The results were obtained as follows: 1) The number of valvular heart disease was 434 patients, which accounts for 2.6% of the total hospitalized patients during the same period. The sex incidence of valvular heart disease were female 48.6%, male 51.4%. The incidences of each valvular heart disease were mitral stenoinsufficiency 31.8%, mitral stenosis 24.2%, mitral insufficiency 21.0%, combined valvular heart disease 12.2%, aortic insufficiency 7.1%, aortic stenoinsufficiency 1.6%, pulmonic stenosis 1.4%, and aortic stenosis 0.7%, in order. 61.5% of all were in third to fifth decade in age distribution. 2) The following were found as etiological factors: rheumatic fever 36.4%, atherosclerosis 1.6%, syphilis 0.9%, and unknown and others 61.3%. 3) The main subjective symptoms were dyspnea, palpitation, cough, orthopnea, sputum, chest pain, fatigue, blood tinged sputum, dizziness, and headache. And the main objective finding were hepatomegaly, venous engorgement, edema, pulmonary congestion, thrill, ascites, splenomegaly, malar flush, and finger clubbing. 5) The disturbance of liver function were found in about 30% of valvular heart disease. 6) The abnormalities of electrocardiographic findings were observed as follows: atrial fibrillation 55.1%, ventricular premature beat 15.2%, first degree atrioventricular block 8.5%, incomplete right bundle branch block 4.1%, complete right bundle branch block 1.4%, second degree atrioventricular block 0.9%, and left bundle branch block 0.9%, in rhythm and conduction disturbance, and left ventricular hypertrophy 44%, right ventricular hypertrophy 18.2%, biventricular hypertrophy 4.6%, left atrial enlargement 19.8%, and right atrial enlargement 3.2%, in chamber enlargement.
Age Distribution ; Aortic Valve Stenosis ; Ascites ; Atherosclerosis ; Atrial Fibrillation ; Atrioventricular Block ; Bundle-Branch Block ; Cardiac Complexes, Premature ; Chest Pain ; Cough ; Dizziness ; Dyspnea ; Electrocardiography ; Estrogens, Conjugated (USP) ; Fatigue ; Female ; Fingers ; Headache ; Heart Valve Diseases* ; Hepatomegaly ; Humans ; Hyperemia ; Hypertrophy ; Hypertrophy, Left Ventricular ; Hypertrophy, Right Ventricular ; Incidence ; Liver ; Male ; Mitral Valve Insufficiency ; Mitral Valve Stenosis ; Pulmonary Edema ; Pulmonary Valve Stenosis ; Rheumatic Fever ; Seoul ; Splenomegaly ; Sputum ; Syphilis ; Tolnaftate