There are many herbs used in the treatment of dermatophytosis as home medicine and Castanea crenata Flos (C.C.F.) is one of that used in Kyung gi-do district. With that regard we tried to examine in vitro antifungal activity of the C.C.F. with its water extract and alcohol extract as the test materials. Until now many authors have studied the antifungal activity with several plant extracts, as like the alcohol extracts of Zanthoxylum piperatum Fructus and Berberis Korea palibin or Fennel oil, and reported that these plant extrscts or essential oiI have good antifungal activities in vitro and in vivo. On that they said that the principal fractions those have strong fungistatic activity were all alikely the fatty acids chemically similar with the well known undecylenic acid. At this in vitro experiment the extracts of C.C.F. were diluted. serially in the Sabourauds dextrose agar and certain portions of fungi (the strains of Trichophyton (Tr.) mentagrophytes and Tr. rubrum) were transplanted into each medium containing different concentrations of test materials then observed its growth for 2 weeks at room temperature. After that we measured the sizes of colony grown in various conditions and compired with that of the normal medium to determine the fungistatic effectiveness. As the result, in the view of the colony sizes, Tr. mentagrophytes and Tr. rubrum equally revealed marked inhibition of its growth only in the media with water extract over the concentration of 10mg/ml in the mediurn, and the critical fungistatic dilution was 20 mg/ml. We could not identified the principal fraction in the water extract of C.C.F.which exhibited antifungal activity. In the comparison of the critical fungistatic dilution with the alcohol extract of Zanthoxylum piperaturn Fructus and Fennel oil, water extract of C.C.F. required tenfold higher concentration for the same effect. However in regarding the utilizing habits of C.C.F. in horne medicine, as topical wet dressing with water boiled solution, we might expect its effect practically. iVow there are problems to be investigated about the chemical natures and physical properties of the C.C.F. and for the antifungal fractions of it, in addition further in vivo study we thought would be interesting.
Agar ; Animals ; Bandages ; Berberis ; Fatty Acids ; Foeniculum ; Fungi ; Glucose ; Horns ; Korea ; Plant Extracts ; Plants ; Tinea ; Trichophyton ; Water ; Zanthoxylum

No abstract available.
Colorectal Neoplasms*

No abstract available.
Child* ; Encephalitis* ; Female* ; Humans

No abstract available.
Adolescent* ; Child* ; Humans ; Periodicals* ; Suicide*

Two cases of Weber-Christian disease are reported. This very rare disease, we had two another reports of case sincc last ten years in The Korean Journal of Dermatology. In our cases both patients are seventeen years old girls and have the histories of remissions and exacerbations for two to three years. The skin lesions of subcutaneous nodules are scattered on the trunk, extremities and even to the hand dorsurns, with the atrophic depressions. Histologic features are typical with faormy histiocytes in the subcutaneous fat tissue. On tne treatments these patients are given oral corticosteroid, antihistaminics and salicylate with some improvments.
Depression ; Dermatology ; Extremities ; Female ; Hand ; Histiocytes ; Humans ; Panniculitis, Nodular Nonsuppurative* ; Rare Diseases ; Skin ; Subcutaneous Fat

No abstract available.
Basal Ganglia* ; Humans

This experimental study was conducted to evaluate the effect of indomethacin and methylprednisolone on PAN-induced nephrosis in rats. Sprague-Dawley rats weighing 150~200gm were used and divided into controls, group I (PAN intraperitoneally), group II(PAN intraperitoneally, followed by indomethacin peritoneally for 12 days), group III (PAN intraperitoneally, followed by methylprednisolone peritoneally for 12 days) and group IV (PAN intraperitoneally, followed by cyclosporin subcutaneously for 12 days). Twenty four-hour urinary protein excretion was measured on day 0, 5, 10 and 17. On the 17th day, rats were sacrificed for the determination of total serum protein, albumin and cholesterol levels. Foot process widths of glomerular epithelial cells were measured, and anionic sites of lamina rara externa were determined by using PEI as cationic probes. The following results were obtained. Twenty four-hour urinary protein excretion (mg/day) of group I was significantly increased to 455.7+/-188.8 on the 5th day compared to 15.2+/-3.7 on day 0 (p<0.01), and increased gradulally to 525.6+/-203.5 on the 10th day, then decreased to 280.6+/-25.2 on the 17th day. In group III, 24 hr urinary protein excretion on 17 th day (180.7+/-64.5) was significantly lower than that of group I (280.6+/-25.2). Total serum protein of group III was significantly lower than that of group I, and serum albumin and cholesterol did not show any significant difference among Group I, II, III and IV. Foot process widths (nm) of glomerular epithelial cells in group I, II, III and IV were 409.5+/-15.2, 387.8+/-49.2, 279.9+/-36.9 and 398.3+/-38.3, respectively. And the value of group of group III was significantly lower than that of group I (p<0.01). The number of anionic sites per 1micrometer length of glomerular basement membrane in Group I, II, III and IV were 10.3+/-1.3, 10.1+/-1.6, 12.5+/-1.5and 10.2+/-1.5, respectively. And the value of group III was significantly lower than that of group I (P<0.01). In conclusion, cyclosporin and indomethacin did not show any significant effect on PAN nephrosis in rat. However, methylprednisolone reduced the urinary protein excretion and showed significant recovery of foot process widths and number of anionic sites of glomerular basement membrane.
Animals ; Cholesterol ; Cyclosporine* ; Epithelial Cells ; Foot ; Glomerular Basement Membrane ; Indomethacin* ; Methylprednisolone* ; Nephrosis* ; Nephrotic Syndrome ; Rats* ; Rats, Sprague-Dawley ; Serum Albumin

During the last one year. 23 selected cases of various glaucomatous eyes were received trabeculectom y ab extemo (5 X 3mm scleral-flap with a large peripheral iridectomy and only two scleral-flap corners sutures) under surgical microscope. Success cases which were controlled ocular tension to normal are 21 eyes(91.3%) out of total 23 glaucomatous eyes. Especially, all 11 eyes of simple open angle glaucoma were obtained excellent normotension after trabeculectomy, But one case of absolute glaucoma was failed because of vitreous prolapse, and another failed case was in group of acute closed glaucoma due to surgical complication of total hyphema(Table 1, 2).
Glaucoma ; Glaucoma, Open-Angle ; Intraocular Pressure ; Iridectomy ; Prolapse ; Trabeculectomy*

Econazole is one of the new imidazole derivatives displaying antifungal and antibacterial properties in vitro and in vivo. The present study was undertaken to evaluate the therapeutic efficacy of Econazole in patients with dermatomycoses anl to determine the minimal inhibitory concentration in vitro. A total of 48 patients with various forrns of dermatomycoses(25 patienta with T. cruris, 13 with T. pedis, l with T. corporis, 4 with T. versicolor and 5 with candidiasis) entered this study at the Departement of Dermatology, University Hospital, College of Medicine, Seoul National University during 3 months period. from July to September, 1976. Dia,gnosis was established clinically as well as microscopically by direct KOH mount. All patients were instructed to apply 1:o Econazole solution two to three times daily on the affected area for four to seven weeks and weekly examination of the clinical lesions and direct KOH mount were performed. In addition, minimal inhibitory concentration for Trichophyton mentagrophy tes was determined by the modified dilution technique in vitro. The results were as follows. 1. Thirty five patients (72. 9F) were cured clinically and microscopieally and thc remainders showed marked clinical improvement but positive KOH mount at 4 th week of treatment. At 7th week, nine (18.8io) of the remainders were cured clinically and microscopically and the overall cure rate at 7th week was 91. 7%. Five patients with tinea cruris experienced trar.sient irritation derrnatitis on their crural regions. 2. The minimal inhibitory coriceritration of Econazole for Trichophyton mentagrophytes was 25 pg per ml. of medium. The authors concluded that the 1 i Econazole was highly effective in the treatment of superficial rnycoses and the side effects were rninimal and only transient.
Dermatology ; Dermatomycoses* ; Dronabinol ; Econazole* ; Humans ; Indicator Dilution Techniques ; Seoul ; Tinea ; Trichophyton

Acquired tufted angioma is a benign, slowly progressive angioma with a characteristic histologic pattern, that was first described by Wilson Jones in 1979. We present herein a case of this rare disease developed in a 43 year old healthy woman. Routine biopsy specimens and an immunoenzymatic staining of factor 7IE showed compatible findings with those cases reported previously. The lesions were surgically excised, and during the two months of follow up, there was no sign of recurrence.
Adult ; Biopsy ; Female ; Follow-Up Studies ; Hemangioma* ; Humans ; Rare Diseases ; Recurrence