Acromelanosis Progressiva which was described by Mishirna et al. In 1962 is a very rare pigmentary disorder and it seems that this is the first case reporting in Korean literature. The patient we observed was 11 years old girl having dark brown macules on the dorsa of her hands and feet, forearms, lower legs and face. These pigmented macules at first appeared on the dorsal surfaces of her fingers and toes when her age of 7. Thereafter these macules spread somewhat progressively to the proximal portions of the extremities and recently those have been spread upon her forearms and lower legs. The same pigmented macules appeared meanwhile on her face when her age of 9 and also have been spread diffusely on the cheeks and eyelids at visiting. Sh was otherwise normal on physically and had no familial history of such pigmentary disorder. But she had mental deficiency (I.Q. 60).
Cheek ; Child ; Extremities ; Eyelids ; Female ; Fingers ; Foot ; Forearm ; Hand ; Humans ; Intellectual Disability ; Leg ; Toes

It is generally accepted that tbe lepromin test is of great value in the type classification and the evaluation of the prognosis of leprosy. But the nature of the antigenicity in lepromin reaction stiIl remains uncertain. The present study was carried out to investigate the antigenic characteriatics of the early(Fernandez) and the late (Mitsuda) reactions to Mitsuda lepromin antigen. Mycobacterium leprae was purified by trypsin digestion from human lepromas, and was broken down by passing 5 times through a French Pressor at 16, 000 p.s.i.. From the broken cell suspension, cell wall, cytoplasm, very low density lipoprotein (VLDL) and lipopolysaccharide (LPS) were prepared. IntradermaI skin tests were perforrned on 30 leprosy patients classified according to the Ridley-Jopling scale (4 TT, 6 BT, 2 BB, 7 BL and 11 LL), with 0. 1ml of the Mitsuda lepromin(intact cells) broken cells, cell wall, cytoplasm, VLDL and LPS antigens. Readings for the early and the late reactions were done 72 hours and 28 days, respectively, after itradermal injections of the above antigens. The results are summerized as follows: 1, Early reactions were elicited by broken cells, cell wall and cytoplasm in all of the patients who could react to Mitsuda lepromin antigen. VLDL and LPS antigens could also elicit early reactions in 9(56)% and in 14(88%), respectively, of the 10 patients who showed positive reaction to Mitsuda lepromin antigen. These results mean that the early reaction may be due to multiple antigena, originated either from M. leprae or from contaminated human tissues. 2. Late reactions were elicited by broken cells and cell wall antigens, but not by cytoplasm antigen, in all of the patients who showed late reactions to Mitsuda lepromin antigen. These results mean that broken cells also produce a late reaction and the specific antigen(s) of the late reaction may reside in the cell wall fraction of the M. leprae.
Cell Wall ; Classification ; Cytoplasm ; Digestion ; Humans ; Lepromin* ; Leprosy ; Lipoproteins ; Mycobacterium leprae ; Prognosis ; Reading ; Skin Tests ; Trypsin

We report a solitary neurilemmoma on the left palm that occured in a 19-year-old man. The mass was a 1 * 1.2 * 0.7cm sized dome which was located between the thenar and hypothenar on the left palm. A biopsy specimen showed histological findings consistent with neurilemmoma:circumscribed nuclear palisading with Verocay bodies.
Biopsy ; Humans ; Neurilemmoma* ; Young Adult

No abstract available.
Autoradiography* ; DNA* ; Ultraviolet Rays*

Cardiac relaxation is impaired in many cardiac disorders and is the subject of extensive investigation. Though measurement of isovolumic relaxation time ought to prove a simple means of quantifying such abnormalities in clinical practice, the problem of defining the timing of mitral valve opening at the onset of ventricular filling has been a difficulty. previous studies have used the 'O' point of the apexcardiogram, but more recently it has been shown that this may be open to considerable error. It was the purpose of the present study to determine the duration of true isovolumic relaxation and the factors influencing its duration, and to evaluate its use as a simple noninvasive measurement of cardiac dynamics in terms of the present approach. True isovolumic relaxation time (IRT) was measured noninvasively from the onset of the aortic component of the second heart sound to the onset of rapid opening of the mitral leaflets from simultaneous recording of echocardiogram, phonocardiogram, electrocardiogram and carotid tracing in 60 normal subjects, 30 male and 30 female and in 50 with hypertension, 28 male and 22 female ranging in age from 20 to 45 years. 1. The duration of IRT was 53.6+/-9.9 msec in normal subjects with no relation to sex. 2. IRT was related to heart rate, systemic blood pressure, and systolic and diastolic time intervals. 1) IRT tended to decrease with increasing heart rate and a regression equation for predicting it in relation to heart rate was 'IRT(msec)=88.97-0.466xH.R.(beats/min)' (P<0.01). 2) IRT tended to increase with increasing systemic blood pressure and a regression equation for predicting it in relation to aortic closing pressure was 'IRT(msec)=5.09+0.459xaortic closing pressure(mmHg)' (P<0.01). IRT was prolonged in patient with hypertension. 3) IRT was in close relation to left ventricular contraction indices such as preejection period(PEP), isovolumic contraction time and preejection period/left ventricular ejection time ratio. 4) There was no relation between IRT and left ventricular pump performance indices such as stroke volume, ejection fraction, fractional shortening and left ventricular dimension. 5) There was strong association between IRT and diastolic time intervals. Authors were impressed through this study that IRT is a useful measurement of left ventricular dynamics in early diastole.
Blood Pressure ; Diastole ; Electrocardiography ; Female ; Heart Rate ; Heart Sounds ; Humans ; Hypertension ; Male ; Mitral Valve ; Relaxation* ; Stroke Volume

No abstract available.
Korea* ; Tuberculosis*

We presented two cases of bullous dermatoses in childhood. The first case was a 13-year-old boy who had numerous tense bullae on the scalp, both forearms and dorsa of hands, trunk and both thighs in symmetrical distribution, but he had not any oral lesion. On histologic examination, subepidermal bullae containing many neutrophils and only a few eosinophils were demonstrated. The lesions began to subside prornptly since 2 days after ornl administration of prednisolone and there was no evidence of recurrence during the follow-up studies of 4 months. The second case was a 14-year-old boy who had erythematous macules, vesicles, bullae and crusts scattered irregularly on almost entire body surface and had some oral lesions. Histologically erythematous macular lesions revealed many microabscesses composed almost entirely oi neutrophils on the tip of dermal papillae but vesicular lesions showed intraepidermal bulla containing numerous eosinophils exclusively. His skin lesions were well suppressed by DDS but reappeared one or two days after cessation of DDS. We thought these two cases were not the typical cases of bullous pemphigoid or dermatitis herpetiforrnis. We did not perform immunologic studies, so we cannot assure that these two cases were belong to either bullous pemphigoid or dermatitis herpetiformis and the so-called benign chronic bullous dermatosis of childhood.
Adolescent ; Dermatitis ; Dermatitis Herpetiformis ; Eosinophils ; Follow-Up Studies ; Forearm ; Hand ; Humans ; Male ; Neutrophils ; Pemphigoid, Bullous ; Prednisolone ; Recurrence ; Scalp ; Skin ; Skin Diseases ; Skin Diseases, Vesiculobullous* ; Thigh ; Transcutaneous Electric Nerve Stimulation

The prevalence of syphilis was sharply decreased throughout the world since the introduction of penicillin into the treatment of syphilis in 1943, however recent in formations seemed to be increased in incidence of syphilis since about 1960. In Korea, recent trends of syphilis can hardly be assesed because there are few reports of it. In order to know the current incidence of syphilis in Seoul we carried out S.T.S. in 1046 healthy young men living in Seoul. At that we classified the man as syphilitic who has positive serologic test on both VDRL and RPCF and has not recieved regular antisyplulitic treatment in the past. The result reveala that the incidence of syphilitic infection is 1.72%, which is slightiy decreased statistical figure than in 1960s. There are no much differences in incidence between each group of age or educational degree. Among the 653 unmarried men, 62.3% of them had experiences of sexual contact and their sex partners were business girls, students and prostitutes in order of frequency.
Commerce ; Equidae ; Female ; Humans ; Incidence ; Korea ; Male ; Penicillins ; Prevalence ; Seoul* ; Serologic Tests ; Sex Workers ; Single Person ; Syphilis*

No abstract available.
Paraquat* ; Poisoning*

No abstract available.
Aluminum Oxide* ; Dental Porcelain*