The clinical and statistical review were carried out with 92 cases of herpetic keratitis at the Dept. of Ophthalmology, St. Mary's Hospital, Catholic Medical College from Jan. 1974 to Aug. 1976. The results were as follow: 1. Herpetic keratitis was most prevalent at the age of 30's and least at those under 10 and 60'. 2. Male and female ratio was about 3 : 1 but the ratio under the age of 20 was even. 3. The most epidemic season was from March to June, amounting to about 56.5% of the total, and exhaustion was the most significant predisposing factor. 4. The simple type of herpetic keratitis was 45 cases (48.9%) of the total while the complicated type was 47 cases(51.1%). Four fifth of simple type was dendritic keratitis with 36cases (39.1%) and disciform keratitis was most frequent among the complicated type with 20 cases (21.7%). 5. Involvement was even between left and right eyes. 80% of binocular cases was primarily involved at the age of over 20's. Among binocular cases, both eyes showed similar signs and course. 6. Vision in the early stage depends on the location of keratitis invloved. Twenty two out of twenty three cases with duration over 3 years displayed and obvious decreased vision less than 0.1 which implied that the longer the duration is, the more evident the disturbance in vIsion is. 7. In 30 cases the effect of 5-ido-2'-deoxyuridine (I.D.U.) was excellent while there was no effective response to the 5-iodo-2'-deoxyuridine (I.D.U.) in 29 cases. In cases resistant against I.D.U., cryotherapy and keratoplasty proved to be very effective.
Causality ; Corneal Transplantation ; Cryotherapy ; Female ; Humans ; Idoxuridine ; Keratitis* ; Keratitis, Dendritic ; Keratitis, Herpetic ; Male ; Ophthalmology ; Seasons ; Telescopes

This study is based on the results of cryo-extraction of the lens in 123 eyes(98 cases) which were operated in Chosun University Hospital between Jan. 1979 and Feb. 1981. The results are summarized as follow: 1. The cryo-extraction have been done for 41 males and 57 females of the 98 patients. 2. The incidences of complication during operation were capsule rupture (5.7%), vitreous loss (4.9%), iris prolapse (1.6%). 3. The incidences of early postoperative complication were hyphema (12.1%). updra wn pupil (8.9%), corneal edema (6.5%), flat anterior chamber (4.9%). 4. The incidences of late postoperative complication were vitreous bulging (5.7%), vitreous opacity (4%), glaucoma(2.4%), uveitis (0.8%), retinal detachment (0.8%). 5. The ccrrected visual acuities before discharge of hospital were: more than 0.5 ... 39.0% (48 eyes), 0.1-0.4 ... 48.8% (60 eyes), less than 0.1 ... 12.2% (15 eyes). 6. The major causes of visual acuity less than 0.1 were vitreous opacity (33.4%), secondary glaucoma (20%), proliferative diabetic retinopathy (20%), corneal opacity (13.4%), retinal degeneration (13.3%).
Anterior Chamber ; Cataract* ; Corneal Edema ; Corneal Opacity ; Diabetic Retinopathy ; Female ; Glaucoma ; Humans ; Hyphema ; Incidence ; Iris ; Male ; Postoperative Complications ; Prolapse ; Pupil ; Retinal Degeneration ; Retinal Detachment ; Rupture ; Uveitis ; Visual Acuity

Authors presented the clinical review and evaluated the therapeutic response to 20 eyes of filamentary keratitis observed at the Department of Ophthalmology, St. Mary's Hospital for last 3 years. 1. The filaments disappeared within 2 days in 11 eyes by mechanical debriment with 0.5% C-M eyedrops, tear substitutes and prednisolone eye drops. 2. 4 of 20 eyes showed disappearance of the filaments within 3 days by the subconjunctival tathion injection combined with instillation of tathion eye drops. 3. For one eye which was resistant to the above therapy treated with continuous wearing of the B and L soft contact lens. In this case the filaments reduced in number from one day and completely disappeared after 6 days' wearing of soft contact lens. Patient discontinued the wearing of soft contact lens one week after. No epithelial filaments have appeared after discontinuance in wearing of the soft contact lens one week later.
Contact Lenses, Hydrophilic ; Humans ; Keratitis* ; Ophthalmic Solutions ; Ophthalmology ; Prednisolone

Ocusert pilo-20 and pilo-40 are soft, flexible plastic devices, sized 13 X 5.7 X 0.3mm in pilo-20, and were inserted under lower or upper conjunctival fornices that gradually released pilocarpine in constant zero-order delivery rate for 7 days. A group of 11 patients(15 eyes) with simple open-angle gloucoma was selected for this study. 1. The Ocusert pilocarpine delivery system could be used effectively in simple open angl glaucoma patients who require lifelong instillation of pilocarpine. 2. The Ocusert system is released constantly the pilocarpine with round the clock intraocular pressure control for 7 days period. 3. After removal of the Ocusert after 7 days. intraocular pressure has gradually increased again after one day's interval. 4. While the Ocusert pilo-40 is placing into the conjunctival fornix, maximum reduction of intraocular pressure was under 20mmHg then the cases of high intraocular pressure over 40mmHg are not effective with single use of the ocusert. 5. Significant side-effect about the ocusert was not observed, only wild foreign body sensation in early time and occassional misplacement or moving of the Ocusert into deep space of upper conjunctival fornix, which is difficult to removal out are observed.
Foreign Bodies ; Glaucoma* ; Humans ; Intraocular Pressure ; Pilocarpine* ; Plastics ; Sensation

OBJECTIVE: The aim of this study was to describe and evaluate the clinical data and short-term treatment response in patients with obsessive-compulsive disorder (OCD) based on an outpatient setting. METHODS: A group of patients with OCD underwent mean 12-weeks treatment with selective serotonin reuptake inhibitors. The patients were divided into two groups according to treatment response, defined as a reduction of the Yale-Brown Obsessive Compulsive Scale total score >35% and CGI of 1 or 2. RESULTS: 1) Among the 249 patients, 24.1% had checking type and 23.7% washing type. Among these two types, 31.9% had mood disorder, 15.0% had anxiety disorder and 24.5% personality disorder as co-morbidity. One hundred fourteen patients (45.8%) responded to the treatment and 135 (54.2%) did not. The responders decreased Y-BOCS scores from 27.9+/-7.2 at baseline to 21.3+/-6.4 and 19.3+/-3.8 at post-treatment 8 and 12 weeks, respectively (repeated measure ANOVA, p=0.039). There were no differences among the treatment responses to serotonin reuptake inhibitors. CONCLUSION: About half of the OCD patients showed a response to pharmacological treatment using SSRI in the outpatient clinic setting for 12 weeks. Long-term and contrast studies of OCD may elucidate further clinical aspects of this disorder in the future.
Ambulatory Care Facilities ; Anxiety Disorders ; Comorbidity ; Humans ; Mood Disorders ; Obsessive-Compulsive Disorder* ; Outpatients ; Personality Disorders ; Serotonin Uptake Inhibitors

The authors developed a computerized electroencephalography imaging system with an IBM PC AT. The EEG signals amplified with a 16 channel EEG machine were digitized at 51.2 Hz (512 samples per epoch). The shifted DC potential and 60Hz artificats were removed by a high pass filter and 60Hz notch filter. A window function consisting of a 10% cosine taper was obtained by weighting the points at either end of the epoch by a cosine bell. A fast Fourier transform was applied to every epoch and the power spectrum estimates were computed in 0.39 Hz steps. The activity estimates for the delta, theta, alpha and beta bands were computed by summimg adjacent values. The outline of the top-down maps was formed from a series of sagittal cuts, then 32 electrodes were placed on the map. A file was created which contained a table of weighting parameters for calculating the interpolated values for every point within the outline. Each weight was in inverse linear proportion to the distance of the pixel to the nearest four electrodes. The map was finally generated with computation of the spectral EEG in each pixel according to the weighting parameter. The functioning of this system was tested with a functional generator and a human subject.
Brain Mapping/methods ; *Diagnosis, Computer-Assisted ; Diagnostic Imaging ; *Electroencephalography ; Human ; *Microcomputers ; Support, Non-U.S. Gov't

OBJECTIVE: The definite causes of obsessive-compulsive disorder (OCD) are still unknown. Evidences from familial, twin and segregation studies support the role of a genetic component in the etiology of OCD. There are growing evidences that OCD has specific neurochemical and neuroanatomical basis. It has been shown that serotonergic neurons play the predominant pathophysiological role in OCD. Recently, it has also been proposed that neurotransmitters other than serotonin play a role in the pathophysiology of OCD, and a series of studies have provided evidence that dopamine is involved in some OCD patients. Therefore, the aims of this study were to investigate the association between dopamine receptor D4 (DRD4) and OCD. METHODS: One hundred and fifteen OCD patients and 160 normal controls participated in this study. Genomic DNA was extracted from their blood. The genotypes and allele frequencies of the DRD4 polymorphism between OCD group and control group were compared. OCD patients were classified into early onset group (age of onset <17) and late onset group (age of onset > or =17) according to their onset age and the genotype and allele frequency were compared between two groups. Using principal component analysis, we had already derived 4 factors from 13 main contents of YBOCS checklist in the previous study and in this study, we investigated the association between these three factors and DRD4 genotypes. RESULTS: In this case-control study, we could find that the L-genotype frequencies of DRD4 were significantly higher in OCD than in normal control groups (chi2 test, p=0.04). There were no difference in genotype frequencies between early onset OCD group and late onset OCD group. In OCD group, patients with L-genotype had higher scores for the religious/somatic factor than the other groups (t test, p=0.009). CONCLUSIONS: The L-genotype of DRD4 may have negative effects on the development of OCD and religious/somatic factor of the obsessive-compulsive symptoms.
Age of Onset ; Case-Control Studies ; Checklist ; DNA ; Dopamine Plasma Membrane Transport Proteins ; Dopamine* ; Gene Frequency ; Genotype ; Humans ; Neurotransmitter Agents ; Obsessive-Compulsive Disorder* ; Principal Component Analysis ; Receptors, Dopamine* ; Serotonergic Neurons ; Serotonin

BACKGROUND: Although physicians state that patients ideally should receive hospice palliative care for 3 months before death, the majority of patients survive less than one month in hospice palliative care. This is too short to do effective hospice palliative care. Therefore, we figured out the problems through the clinical considerations about terminally ill cancer patients who had died in hospice unit. METHODS: From July to December in 2003, 107 patients with terminally ill cancer who had died in Sam Anyang Hospice Unit were enrolled in this study. For getting the informations about patients characteristics, we reviewed the medical records and interviewed the patients on the first visit. RESULTS: There were 70 males (65%) and 37 females (35%), and median age of patients was 60 years (range 23-93). The most common cancer was stomach cancer (18 patients, 17%). Forty seven patients (44%) took analgesics, the others 60 (56%) not. The most common symptom was pain (75 patients, 70%) and the most prevalent reason for admission was also pain (60, 56%). The most prevalent physician specialty who transferred patients or referred to local hospital was other internal medicine (48 patients, 44%), followed by hemato-oncology (38, 36%), surgery (12, 11%) and others (9, 9%). The median duration between the day when the patients were diagnosed as terminally ill cancer patient and the day when they were referred to hospice center is 48 days. The median survival in hospice palliative care is 30 days. The median hospitalization is 19 days. CONCLUSION: We found that lack of recognition about hospice palliative care of physicians, patients and families made the length of hospice palliative care too short. To do effective hospice palliative care, it needs education and promotion for them constantly.
Analgesics ; Education ; Female ; Gyeonggi-do ; Hospices* ; Hospitalization ; Humans ; Internal Medicine ; Male ; Medical Records ; Palliative Care ; Stomach Neoplasms ; Terminally Ill*

Ventricular arrhythmia is known as a major cause of sudden death in patients with heart disease, especially in patients with myocardial infarct. Programmed electrical stimulation (PES) is used in order to identify patients with high risk of ventricular arrhythmia, but it is invasive. So ventricular late potential is studied, which can be performed safely. Ventricular late potential was measured in the 65 normal subjects, 17 patients with in-hospital period acute myocardial infarction and 29 patients with old myocardial infarction using signal-averaged high resolution EKG, Mac-15. The positive criteria of ventricular late potential was one of the following : The duration of TQRS is more than 120 msec, or the amplitude of RMS is less than 25microV, or the duration of LP 40 is more than 40 msec. The results are as follows : 1) Among 65 normal subjects(male ; 33, female ; 32), total QRS duration(TQRS)was 103.9+/-8.3msec(mean S.D), terminal 40msec root mean square amplitude(RMS) 47.8+/-24.3uV and terminal 40msec mean amplitude was 32.5+/-15.4uV. Variables of ventricular late potential showed no significant difference by age. 10 subjects showed positive ventricular late potential. 2) Among 17 patients with in-hospital period myocardial infarction, there was no significant difference in variables of ventricular late potential between patients with ventricular arrhythmia(3 subject) and patients without ventricular arrhythmia(14 subjects). 3) Among 29 subjects with old myocardial infarction, TQRS showed significant differrence between patients with ventricular arrhythmia(3 subjects) and patients without ventricular arrhythmias(26 subjects). All of the patients with ventricular arrhythmia(100%) and 6 subjects(24%) of the patients without ventricular arrhythmia showed positive ventricular late potential, and the difference was significant statistically between groups(p value<0.05). This showed that ventricular late potential is helpful in predicting the risk of ventricular arrhythmia among patients with old myocardial infarction.
Arrhythmias, Cardiac* ; Death, Sudden ; Electric Stimulation ; Electrocardiography ; Female ; Heart Diseases ; Humans ; Myocardial Infarction*

BACKGROUND: Patients with non-Hodgkin's lymphoma who do not respond to first-line chemotherapy or those who relapse after obtaining a complete response have a poor prognosis and are rarely cured with usual salvage chemotherapy. We investigated the treatment responses, toxicities, prognostic factors and mobilization efficacy of peripheral blood stem cells (PBSC) used as salvage chemotherapy. METHODS: 55 patients with refractory (36) or relapsed (19) NHL were treated from Novembr 1997 to October 1999 with IVAM (ifosfamide, etoposide, cytarabine, methotrexate) regimen. Each patients was scheduled to receive one to three cycles of chemotherapy. When the leukocyte count reached 5x109/L after chemotherapy, PBSC collection was performed. The treatment was repeated every 4 weeks. RESULTS: The median age was 48 years (range, 19-76). Median 2.1 cycles of chemotherapy were administered. 15 patients (27.3%) achieved complete response and 29 (52.7%) partial response, with an overall response rate of 80.0%. Myelosuppression was the major toxicity, with 98.2% of grade 3, 4 neutropenia and thrombocytopenia, but there was no serious hemorragic event. Neutropenic fever occurred in 25.5% of the patients with one treatment-related death due to sepsis. Non-hematologic toxicity was modest. PBSC was collected in 36 patients for high dose chemotherapy and autologous stem cell transplantation. The median number of mononuclear cells collected was 9.9x108/kg and the median number of CD34(+) cells collected was 11.9x106/kg. After a median follow-up of 13 months (range, 3-26), median progression free survival were 12 months and median overall survival has not been reached yet. 1-year overall survival and progression free survival were 61.9% and 46.1%, respectively. In univariate analyses, unfavorable prognosis was associated with poor performance status (p=0.001), high LDH (p=0.041), stage III,IV (p=0.04), extralymphatic lesion (p=0.027), B sx (p=0.034), bone marrow involvement (p=0.039) and performing high dose chemotherapy (p=0.005). Multivariate analysis showed that performance status(p=0.0042), B sx(p=0.049) was a significant independent risk factors for death. CONCLUSION: These results suggest that IVAM is an effective salvage chemotherapy for refractory or relapsed NHL and allow effective PBSC collection for high dose chemotherapy and autologous PBSCT.
Bone Marrow ; Cytarabine ; Disease-Free Survival ; Drug Therapy* ; Etoposide ; Fever ; Follow-Up Studies ; Humans ; Leukocyte Count ; Lymphoma, Non-Hodgkin* ; Multivariate Analysis ; Neutropenia ; Prognosis ; Recurrence ; Risk Factors ; Sepsis ; Stem Cell Transplantation ; Stem Cells ; Thrombocytopenia