The purpose of this study is to introduce the patients with bilateral cleft lip nose have lots of distinctive anatomical features such as short columella, inferior displacement of the medial crura of alar cartilage, lowering of the alar dome, flattened tip of the nose, widened nostril sill and prominent vestibular skin web. Although millard, Kaplan and Wray have introduced columellar lengthening by fork flap, it was difficult to achieve satisfying results without reconstructing the nasal skeletal framework of the cleft lip nose deformity for their anatomical distinctiveness. We have performed rhinoplasty on 7 patients with bilateral cleft lip nose from January. 1995 to August. 1997, using onlay calvarial bone graft and suture suspension technique. Operation was performed on basic anatomical structure, skeletal framework using outer table of calvarial bone pushed into the nasal tip area and suspension suture was applied to the framework with anteroinferior projection of nasal tip projection vector by cantilever effect of the calvarial bone which carried out nearly normal anatomical nasal structure. We have obtained satisfying results without complication in all seven cases. In conclusion the method which authors have used shows several advantages. First, it was possible to obtain the substantial skin lengthening in anterior and inferior direction by "Tent-Pole effect" in which creating bony structure projected into nasal tip and traction suturing of the deformed alar cartilages. Secondly, columellar lengthening and close to normal nostril shape was obtained and thirdly, re-deformation of corrected structure was prevented. An expected problem in above method is resorption of grafted calvarial bone which expected to maintain its position under influence of alternation and reformation by reaction between chondroblast and chondroclast results in fibrous tissue replacement, yet long term follow up is necessary for futher evaluation.
Cartilage ; Chondrocytes ; Cleft Lip* ; Congenital Abnormalities* ; Follow-Up Studies ; Humans ; Inlays ; Nose* ; Rhinoplasty ; Skin ; Sutures* ; Traction ; Transplants*

No abstract available.
Head* ; Pancreas*

No abstract available in English.
Achilles Tendon ; Rupture

The Dandy-Walker syndrome is a developmental disorders of the brain characterized by cystic deformity of the 4th ventricle and agensis of the cerebellar vermis. Other systemic anomalies and chromosomal abnormalities are associated with this syndrome. We are experienced a case in a 9 months old male infant who presented initially with frequent vomiting, low birth weight, On the physical examination, a prominent occiput, palpable mass below the right upper quadrant, pulmonary valve stenosis, congenital dislocation of the hips, ventral flexion of fingers, clubfoots and the rocker-bottom deformities of feet were present. On the chromosomal study, there were chromosomal polymorphisms in a thickened C-band of chromosome No. 1 by C-banding method. The brain CT revealed a large, thin-walled, low density mass of CSF without enhancement in the posterior fossa, showing upward displacement of cerebellar hemisphere with absent inferior vermis(or associated with dysplastic cerebellar hemisphere). A brief review of the related literatures were included in this report.
Brain ; Chromosome Aberrations* ; Clubfoot ; Congenital Abnormalities ; Dandy-Walker Syndrome* ; Dislocations ; Fingers ; Foot ; Hip ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Male ; Physical Examination ; Pulmonary Valve Stenosis ; Vomiting

Local deposition of antibiotics has become increasing popular in the management of open fractures or osteomyelitis, and several substances have been employed as the vehicle for delivery. Although the elution characteristics of some substances have been documented, a comparative study of the characteristics of the commonly used substances were performed in order to establish the clinical indications for particular vehicles. Carriers were prepared, which were human iliac cancellous bone, bovine cancellous bone matrix(Lubboc?), absorbable gelatin sponge(Gelfoam?), fibrin glue(Beriplast? P) and polymethylmethacrylate(CMW?) for elution characteristics of vancomycin. The each carriers were immersed on the 20 ml of PBS and then obtained the samples for analysis of concentration of vancomycin at first, second, third, fourth, fifth, sixth, fourteenth, twenty-first, twenty-eighth day after immersion. The assay technique was fluorescent polarization immunoassay(Abbott, Dallas, Texas, U.S.A.). Nearly 50% of vancomycin was released from human iliac cancellous bone, Lubboc? and fibrin glue during the first 3 days, and negligible after first week. Gelatin sponge produced high local concentration of vancomycin during the first week. PMMA eluted the only 6% of vancomycin during the first day and trace amount detected as long as 4 weeks. There are significant statistical difference among carriers at second and fourth week(ANOVA test, P < 0.05). The authors considered that human iliac cancellous bone, Lubboc? ,Gelfoam? and fibrin glue may be best employed when brief antibiotic coverage is required, whereas PMMA may be better suited for long-term coverage.
Anti-Bacterial Agents ; Fibrin ; Fibrin Tissue Adhesive ; Fractures, Open ; Gelatin ; Gelatin Sponge, Absorbable ; Humans ; Immersion ; In Vitro Techniques ; Osteomyelitis ; Pharmacokinetics ; Polymethyl Methacrylate ; Porifera ; Texas ; Vancomycin

A clinical review of 31 cases of multiple myeloma which were diagnosed by criteria of the SWOG between May 1983 and February 1990 at Yeungnam University Hospital was done. The results were as followings: 1. The peak incidence was in 7th decade and male to female ratio was 1.8:1. 2. The most common presenting symptom at first diagnosis was bone pain (58%), but fever, dyspnea, dizziness and palpable mass were also noted. 3. The distribution of laboratory findings as following diagnostic criteria of Southwest oncology group (SWOG): Plasmacytoma on tissue biopsy was noted 6 cases, bone marrow plasmacytosis with more than 10% plasma cells was 22 cases, monoclonal globulin spike on serum electrophoresis was 24 cases, lytic bone lesions was observed 22 cases. 4. Initial clinical stages were classified as 2 cases in stage I, 3 cases in stage II, 26 cases in stage III (84%). 5. Immunoelectrophoresis revealed the distribution of IgG 64%, light chain 22%, IgA 10%, Kappa to Lambda ratio of 1.1:1. 6. Hematologic & biochemical findings revealed anemia with <8.5% of hemoglobin in 42%, hypercalcemia with <10.6 mg% of serum calcium in 22%, azotemia >2.0 mg% of serum creatinine in 19%. 7. The multiple punched out lesion of bone x-ray examination were noticed skull (65%), rib (42%), L-spine (35%), pelvis (23%), T-spine (19%). The initial skeletal roentgenographic findings showed osteoporosis, osteolytic lesion and fracture in 55%, only osteolytic lesion in 23%, only osteoporosis in 10%. 8. Complications of multiple myeloma, such as 10 cases of renal impairment, 8 cases of infection, 16 cases of compression fracture of spine were observed.
Anemia ; Azotemia ; Biopsy ; Bone Marrow ; Calcium ; Clinical Study* ; Creatinine ; Diagnosis ; Dizziness ; Dyspnea ; Electrophoresis ; Female ; Fever ; Fractures, Compression ; Humans ; Hypercalcemia ; Immunoelectrophoresis ; Immunoglobulin A ; Immunoglobulin G ; Incidence ; Male ; Multiple Myeloma* ; Osteoporosis ; Pelvis ; Plasma Cells ; Plasmacytoma ; Ribs ; Skull ; Spine

We report a case of MALT lymphoma in a 49-year-old woman. Her disease occurred simultaneously in the mucosa of her right upper eyelid conjunctiva and in her left nostril as ulcerating tumors associated with itchy ichthyosiform skin lesions on the trunk, hyperkeratotic palms and soles, and dystrophic nails. Histopathological examinations revealed consistent findings of MALT lymphoma with dissemination; i.e., diffuse infiltrates of lymphoplasmacytoid cells with a few Russel body-like structures, eosinophils, some shoddy granulomas under the irregularly hyperplastic epidermis, and diffuse infiltrates of CCL ( centrocyte-like ) cells and small lymphocytes inside and outside many lymphoid follicle-like structures in the subcutaneous tissue forming florid lymphoepithelial lesions. She died after 27 months duration of her disease with worsening of ichthyosiform skin lesions and dystrophic nails in spite of total excision of the tumors. We discuss the clinical and histopathologic features of MALT lymphoma with dissemination and the various similar diseases to differentiate.
Conjunctiva ; Eosinophils ; Epidermis ; Eyelids* ; Female ; Glycogen Storage Disease Type VI ; Granuloma ; Humans ; Lymphocytes ; Lymphoma, B-Cell, Marginal Zone* ; Middle Aged ; Mucous Membrane ; Skin ; Subcutaneous Tissue ; Ulcer

No abstract available.
Duodenal Obstruction*

Animal models are useful tools to study the molecular basis of schizophrenia pathophysiology and efficacy of potential therapeutic agents. Schizophrenia animal models can be subdivided into three classes ; drug-induced models, genetic models, and environmental models and each model is designed based on specific traits corresponding to the characteristic symptoms of human schizophrenia patients. Psychomotor agitation and sensitivity to psychotomimetic drugs are often thought to reflect positive symptoms. Social interaction deficits and affective impairments are known to correspond to negative symptoms. Also, cognitive symptoms have been linked to the working memory impairments, attention deficits and related cognitive deficits in animals. To analyze such components in quantifiable manners, various behavioral paradigms have been developed and utilized. Here, we overview these animal models, focusing on underlying rationales for their use in the context of schizophrenia research.
Animals ; Behavior, Animal ; Humans ; Interpersonal Relations ; Memory, Short-Term ; Models, Animal* ; Models, Genetic ; Neurobehavioral Manifestations ; Psychomotor Agitation ; Schizophrenia*

Since Oct. 1, 1983 until April 15, 1986, authors analyzed variable combined imaging diagnosis andhistopathologic correlation for confirmed 100 breast carcinoma among 2773 patients whom authors took care of them.1. Incidence of female breast carcinoma was 3.6% among 2773 patients who visited Yong Dong Severance Hospital, andoverall breast carcinoma occupied 29.7% among 337 confirmed breast diseases. 2. Prevalent cancer age for Koreanwomen breast carcinoma was ages between 40-49 years old(42%) however authors experienced 5% breast carcinoma amongtwentieth, and 22% breast carcioma among thirtieth. 3. Most common histopathologic type for breast carcinoma wasinfiltrating ductal carcinoma, scirrhous type(65). And most common breast parenchymal pattern related to breastcarcinoma was DY pattern(42%) followed by N1 pattern(25%). 4. Common film mammographic findings of breastcarcinoma were: ill defined bordered mass(68.4%), spiculation of mass(82.9%), vessel dilatation (59.8%) and thencalcification (44.4%). 5. Frequently visible ultramammographic findings were; irregular mass contour(79.6%),nonuniform internal echoes(87.0%), and posterior wall shadowing (86.0%). 6. Trials of above combined imagingmodalities for breast carcinoma resulted in his sensitivity of diagnosis(93.3%).
Breast Diseases ; Breast Neoplasms ; Breast ; Carcinoma, Ductal ; Diagnosis ; Dilatation ; Female ; Humans ; Incidence ; Shadowing (Histology)