There were 7 cases of Vogt-Koyanagi-Harada Syndrome who visited The National Medical Center during the period of last 5 years. They were studied clinically. The findings were as follows: 1. The cases including 3 males and 4 females, were from 17 to 46 years of age. 2. Headaches and visual disturbances were the main initial complaints. 3. Visual disturbances were complained bilaterally within 10 days after the onset at late. Most of the eyes showed poor visual prognosis. 4. Chronic course of uveitis resulted in posterior synechia, complicated cataract and keratic precipitates leading to severe destructions and alternations of the eyes. Ophthalmoscopical examinations, therefore were mostly unable. 5. Hearing disturbances were complained in 3 cases. All of them were of neurogenic type but less in seventy. 6. Vitiligo and poliosis were present in all cases within a year after the onset. The earliest manifestation occurred in 2 months after the onset. Although the back and buttock were the main location of vitiligo, localized white patches around the orbit involving lids were characteristic. Poliosis were present in eye lashes and even in axillary hair as well as in the scalp. 7. 4 cases were complaining alopecia in the scalp, followed soon by the regeneration of hair. 8. Laboratory examinations of blood and urine were normal. There were no hyperglycemia and pleocytosis of spine fluid. Neurological examination also showed no abnormal findings. 9. It was interesting to see a case of a typical manifestation consisting of severe prolonged headache. vitiligo and poliosis without any ocular complaints. 10. Treatment with corticosteroids improved the eye conditions very little in the present cases.
Adrenal Cortex Hormones ; Alopecia ; Buttocks ; Cataract ; Female ; Hair ; Headache ; Hearing ; Humans ; Hyperglycemia ; Leukocytosis ; Male ; Neurologic Examination ; Orbit ; Prognosis ; Regeneration ; Scalp ; Spine ; Uveitis ; Uveomeningoencephalitic Syndrome* ; Vitiligo

Large numbers of any population of shoe wears have abnormalities of the skin of their toe clefts, but most of them have no recognized pathogen there. The term tinea pedis, or athlete's foot, should be strictly reserved for those infected with a dermatophyte fungus. The prevalance of this condition in the general population is unknown, and a survey of a true representative sample would present considerable difficulties. The toe webs and the soles as well as other area of the feet which showed any clinical changes were scraped and the scales ohtained were examined microscopically after clearing with 10% KOH and were inoculated on to Sabouraud's glucose agar. Pathogenic fungi were identified in slide culture and fermentation test with macro and microscopically. Total 1669 workers were examined in Cotton Mill Industry. Patients from 648 (38.7%) workers {85(28.1%) of 302 men and from 563 (41.1%) of 1367 women) showed clinically diagnosed tinea pedis. Their ages varied from 15 to over 50 years, with most of those examined in the second decade, especially women. The positivc rate of 10% KOH preparation found, that 21.3% of 72 men and 78.7% of 267 women were clinical diagnosed. An analysis of 221 identified strains with mycologic examination has shown that trichophyton rubrum (88 strains) is more isolated than T.mentagrophytes (66 strains), also candida species (50 strains are included C. albicans, C. tropicalis, C. pseudotropicalis, C. parakrusei and C. stellatoidea.) Authors figures indicate that the incidence of dermatophytosis is high in workers of Cotton Mill Industry for following reasons; 1. Environmental condition of working place are maintained constantly high temperature and humidity. 2. Workers are used in industrial bath room after working, and living a communal life.
Agar ; Arthrodermataceae ; Baths ; Candida ; Female ; Fermentation ; Foot ; Fungi ; Glucose ; Humans ; Humidity ; Incidence ; Male ; Shoes ; Skin ; Tinea Pedis ; Tinea* ; Toes ; Trichophyton ; Weights and Measures

No abstract available.
Arthritis, Infectious* ; Hip Joint* ; Hip*

Experimental brain infarcts in rats were studied light and electron microscopically to investigate the factor(s) controlling contrast enhancement on CT scans of the infarcts. Brain infarction was induced by injection of fine autologous blood clots through the right internal carotid artery and the affected brain was processed for examination 1 day, 2 day, and 1, 2, 4, 6 and 8 weeks after the injection. The lesion of early, necro - degenerative stage(1 day to 1 week) showed structural disintegration of capillary endothelial cells with dissolution of tight junctions. The lesion of middle, regenerative stage(2 to 4 weeks) was characterized by proliferation of new capillaries, They had well - formed tight junctions and continuos basement membrane. The endothelial cells, however, had intraluminal villous projections and many pinocytotic vesicles, suggesting an increased permeability. The capillaries matured at late, reparative stage(8 weeks), appearing similar to those in normal brain tissue except that they were loosely surrounded by astrocytic foot processes. It was presumed that the ncreased permeability of new capillaries might play an important role for contrast enhancement observable clinically during the middle stage(2 to 4 weeks).
Animals ; Basement Membrane ; Brain Infarction ; Brain* ; Capillaries* ; Carotid Artery, Internal ; Endothelial Cells ; Foot ; Permeability ; Rats* ; Tight Junctions ; Tomography, X-Ray Computed

No abstract available.
Cloning, Molecular* ; DNA* ; Helicobacter pylori* ; Helicobacter* ; Sequence Analysis, DNA* ; Urease*

In a series of 93 cases of verified brain tumors visited to The National Medical Center from Nov. 1958 to March 1963 were studied clinically in regard to the ocular symptoms. The results of the study include following findings: 1. 81.3% of visual disturbances were present including 43 cases of monocular and binocular blindness. 2. Among 46 cases who were able to be examined, 78.7% showed abnormal visual fields. The most frequent type of field defect was homonymous hemianopsia, which showed high incidence in cerebral paragonimiasis. 3. The incidence of papilledema was 33.3%. They were mostly bilateral, and showed much higher incidence of 64.2% in infra tentorial tumors. 4. Optic atrophy was found in 36.5%. They were mostly of bilateral affection. There were no big difference between the incidence of primary optic atrophy and that of secondary. Primary atrophy were seen most frequently in cases of cerebral paragonimiasis as well as frontal and sellar region tumors. 5. The incidence of abnormal pupillary reflexes was 48.3%. Most of these cases are due te amaurotic mydriasis. Anisocoria occurred 17.2% of the series. 6. The incidence of nystagmus was 17.2% and was most frequently seen in cases of inf ra tententorial tumors. 7. 7.5% of abducens palsy were the most frequent occurence among extraocular muscle palsies. 8. It was specific that the affection of corneal sensibility was ipsilateral to the location of the tumors. The incidence of corneal affection was higher in cases of infratentorial tumors than that of supratentorial group. 9. Lagophthalmos occurred in 10.7% of the cases. All of them were due to facial palsy.
Anisocoria ; Atrophy ; Blindness ; Brain Neoplasms ; Facial Paralysis ; Hemianopsia ; Incidence ; Infratentorial Neoplasms ; Mydriasis ; Optic Atrophy ; Papilledema ; Paragonimiasis ; Paralysis ; Reflex, Pupillary ; Telescopes ; Visual Fields

PURPOSE: We analyzed disease free survival and the prognostic factors of liposarcoma in the extremity. MATERIALS AND METHODS: Between 1994 and 2005, of 44 patients who were diagnosed and treated for liposarcoma of the extremity, 40 patients were restrospectively analysed. 13 out of 40 patients got postoperative radiotherapy. We examined local recurrence, distant metastasis and disease free 5-year survival rate. We also analyzed clinical prognostic factors, such as age, gender, size of tumor, prior unplanned excision, histologic type, surgical excision margin and postoperative radiotherapy respectively. RESULTS: There were 3 cases of local recurrence and 4 cases of distant metastasis. The disease free 5-year survival rate was 85.0%. 26 patients presented with myxoid, 8 well differentiated, 4 round cell, 1 pleomorphic and 1 dedifferentiated histology. The disease free 5-year survival rate of mixoid, well differentiated and round cell liposarcoma were 100.0%, 84.6% and 75.0% (p=0.419). The 5-year disease free survival rate was 90.6% in negative surgical margin (n=25) and 62.5% in positive surgical margin (n=15) (p=0.003). CONCLUSION: Our study suggests that surgical excision margin is significant prognostic factor for 5-year disease free survival rate.
Disease-Free Survival ; Extremities ; Humans ; Liposarcoma ; Neoplasm Metastasis ; Recurrence ; Survival Rate

No abstract available.
Humans ; Hypersensitivity* ; Skin*

No abstract available.
Child* ; Humans ; Purpura, Thrombocytopenic, Idiopathic*

No abstract available.
Helicobacter pylori* ; Helicobacter* ; Urease*