1.The Effect of Magnesium Pretreatment on Serum Potassium Concentration and Hemodynamic State in Rabbits during Continuous Regular Insulin(RI) Infusion.
Jeong Hwan CHOI ; Chul Woo LEE
Korean Journal of Anesthesiology 1998;35(5):839-845
Background: Insulin is known to act as second effector that provides potassium transfer from extracellular fluid to intracellular fluid, thus causing hypokalemia and arrythmia. We evaluated the effect of magnesium sulfate treatment on hemodynamics and serum potassium concentration, induced by continuous infusion of regular insulin solution in rabbits. Method: Twenty-four rabbits were divided into four groups for the experiment. Group I was given intravenouse injection of 5 ml of normal saline and continuous dripping of 7.5 U of RI. Group II was pretreated with 30 mg/kg of magnesium sulfate, followed by continuous dripping of 7.5 U of RI. Group III was given 5 ml of normal saline and 15 U of RI. And Group IV was administered 15 U of RI after 30 mg/kg of magnesium sulfate pretreatment. Venouse blood sampling was done before pretreatment, and after 5, 30, 60 and 120 minutes respectively. Heart rate and arterial blood pressure were taken at the same intervals. Result: 1) There was no significant change in serum potassium concentration in groups injected with 7.5 units of RI respectively (groups I and II), regardless of magnesium pretreatment. But in groups injected with 15 units of RI, the group that was not pretreated with magnesium (Groups III) showed a decrease in serum potassium concentration from 3.39+/-0.57 Eq/L to 2.29+/-0.71 mEq/L, while the concentration in the pretreated group (Group IV) decreased more significantly from 3.35+/-0.50 mEq/L to 1.81+/-0.41 mEq/L. 2) Pulse rate did not change significantly in groups that received continuous infusion of 7.5 units of RI (groups I and II) regardless of magnesium pretreatment, but increased significantly in groups injected with 15 units of RI (groups III and IV), pretreated or not. The pretreated group (group IV) had a more significant rise in pulse rate compared with the group that was not pretreated (group III). 3) In all of the groups, those pretreated with magnesium (groups II and IV) and those not pretreated (groups I and III), there was no significant change in systolic and diastolic blood pressures. Nor was arrhythmia detected. Conclusion: The above results indicate that while magnesium sulfate pretreatment at 30 mg/kg with insulin infusion affects serum potassium concentration, has an antiarrhythmic effect, and may induce tachycardia, it does not have any significant effect on blood pressure.
Arrhythmias, Cardiac
;
Arterial Pressure
;
Blood Pressure
;
Extracellular Fluid
;
Heart Rate
;
Hemodynamics*
;
Hypokalemia
;
Insulin
;
Intracellular Fluid
;
Magnesium Sulfate
;
Magnesium*
;
Potassium*
;
Rabbits*
;
Tachycardia
2.Two Cases of Allergic contact Dermatitis due to Paratertiary Butyphenol Formaldehyde Resin - Containing Shoes.
Hwan Pyo JEON ; Sung Woo CHOI ; Hee Chul EUN
Korean Journal of Dermatology 1989;27(6):696-699
The paratertiary butylphenol formaldehyde resin (PTBP-FR) is commonly used as a shoe adhesives because it sticks rapidly, is durable and pliable, and maintains good bond strength at raised temperature. We report two cases of allergic contact dermatitis due to PTBP-FR-containing shoes. Two women visited our department because of the skin rash on their .
Adhesives
;
Dermatitis, Allergic Contact*
;
Exanthema
;
Female
;
Formaldehyde*
;
Humans
;
Shoes*
3.Clinical aspects of the preoperative selective angiogrpahy in patients and periampullary tumors.
Jin Woo RYU ; Sang Yong CHOI ; Bum Hwan KOO
Journal of the Korean Surgical Society 1992;42(1):37-42
No abstract available.
Humans
4.Solitary Bone Cyst Patella
Bu Hwan KIM ; Jong In YIM ; Woo Sung CHOI
The Journal of the Korean Orthopaedic Association 1996;31(2):377-380
The common sites of solitary bone cyst(SBC) are humerus, femur and less common sites are tibia, calcaneus, ilium, fibula, radius and ulna. Ischium rib, scapula, spine, clavicle and patella are rare sites of solitary bone cyst. As mentioned above, SBC of patella is very rare and on view of literatures we could find only one reported case which was treated by patellectomy. We also experienced one case of SBC located at patella, so we report this case with review of literatures.
Bone Cysts
;
Calcaneus
;
Clavicle
;
Femur
;
Fibula
;
Humerus
;
Ilium
;
Ischium
;
Patella
;
Radius
;
Ribs
;
Scapula
;
Spine
;
Tibia
;
Ulna
5.Central giant cell granuloma in mandible: report of a case
Eui Ewung LEE ; In Ho CHA ; Woo Hwan CHOI
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 1991;13(4):428-435
No abstract available.
Giant Cells
;
Granuloma, Giant Cell
;
Mandible
6.Clinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer.
Chi Hwan CHOI ; Won Dong KIM ; Sang Jeon LEE ; Woo Yoon PARK
Radiation Oncology Journal 2012;30(3):99-107
PURPOSE: The aim of this study was to identify clinical predictive factors for tumor response after preoperative chemoradiotherapy (CRT) in rectal cancer. MATERIALS AND METHODS: The study involved 51 patients who underwent preoperative CRT followed by surgery between January 2005 and February 2012. Radiotherapy was delivered to the whole pelvis at a dose of 45 Gy in 25 fractions, followed by a boost of 5.4 Gy in 3 fractions to the primary tumor with 5 fractions per week. Three different chemotherapy regimens were used (5-fluorouracil and leucovorin, capecitabine, or tegafur/uracil). Tumor responses to preoperative CRT were assessed in terms of tumor downstaging and pathologic complete response (ypCR). Statistical analyses were performed to identify clinical factors associated with pathologic tumor response. RESULTS: Tumor downstaging was observed in 28 patients (54.9%), whereas ypCR was observed in 6 patients (11.8%). Multivariate analysis found that predictors of downstaging was pretreatment relative lymphocyte count (p = 0.023) and that none of clinical factors was significantly associated with ypCR. CONCLUSION: Pretreatment relative lymphocyte count (%) has a significant impact on the pathologic tumor response (tumor downstaging) after preoperative CRT for locally advanced rectal cancer. Enhancement of lymphocyte-mediated immune reactions may improve the effect of preoperative CRT for rectal cancer.
Chemoradiotherapy
;
Deoxycytidine
;
Fluorouracil
;
Humans
;
Leucovorin
;
Lymphocyte Count
;
Multivariate Analysis
;
Pelvis
;
Rectal Neoplasms
;
Capecitabine
7.A Case of Niemann Pick Disease.
Sung Hwan KIM ; Young Joo CHOI ; In Ho KIM ; Sang Woo KIM
Journal of the Korean Pediatric Society 1983;26(10):1039-1043
No abstract available.
Niemann-Pick Diseases*
8.The Effects of Intraoperative Epidural Morphine on Postcesarean Intravenous Patient-Controlled Analgesia.
Duck Hwan CHOI ; Jie Ae KIM ; Woo Seog SIM
Korean Journal of Anesthesiology 2000;38(1):112-117
BACKGROUND: Intravenous patient-controlled analgesia (IV-PCA) has been widely used for pain relief after cesarean delivery under epidural anesthesia. However, IV-PCA alone has a limited effect on early postoperative pain relief. Epidural morphine injected intraoperatively could alleviate the early postcesarean pain. We evaluated the effects and side effects of intraoperative epidural morphine on postoperative IV-PCA. METHODS: Forty patients scheduled for cesarean section under epidural anesthesia were randomly assigned to one of two groups. The patients in the intravenous group (IV group, n = 20) received intravenous morphine 3 5 mg after the operation in the recovery room when patients complain of pain, and the patients in the epidural group (EPI group, n = 20) received intraoperative epidural morphine 3 mg after fetus delivery. After that, both groups received morphine IV-PCA (no basal infusion, bolus 1.0 mg, lock-out time 6 min). Analgesic efficacy, degree of patient satisfaction, drug consumption and side effects were compared at 4 and 24 hours after surgery. RESULTS: The EPI group had significantly lower VAS for pain at 4h after surgery on movement and resting than the IV group, whereas no significant difference was observed at 24h after surgery. The cumulative morphine consumptions at 4h and 24h after surgery were more in the IV group (each, P < 0.001). Fewer patients in the EPI group had drowsiness at 24h after surgery, but there were no significant differences in other side effects and degree of satisfaction between the two groups. CONCLUSIONS: We conclude that intraoperative epidural morphine was effective with less side effects for postoperative IV-PCA in the cesarean patients under epidural anesthesia.
Analgesia, Patient-Controlled*
;
Anesthesia, Epidural
;
Cesarean Section
;
Female
;
Fetus
;
Humans
;
Morphine*
;
Pain, Postoperative
;
Patient Satisfaction
;
Pregnancy
;
Recovery Room
;
Sleep Stages
9.A study on the factors influencing pregnant women's behavior in oral iron supplement.
Cheol Hwan KIM ; Jung Eal CHOI ; Ok Hee JEON ; Tai Woo YOO ; Bong Yul HUH
Journal of the Korean Academy of Family Medicine 1991;12(4):1-7
No abstract available.
Iron*
10.DNA Methylation-Based Age Estimation in the Forensic Field.
Ja Hyun AN ; Kyoung Jin SHIN ; Ajin CHOI ; Woo Ick YANG ; Hwan Young LEE
Korean Journal of Legal Medicine 2013;37(1):1-8
The estimation of age is an important issue in forensic science, and the forensic community has attempted many times to establish methods for solving this issue. Aging leads to alterations in tissues and organs at the molecular level. These alterations at the molecular level may aid forensic scientists to estimate the age of a living person or a dead body. Initially, the focus was on the genetic components of aging, but recently, epigenetic mechanisms have emerged as the key contributors to the alterations in genome structure and function that accompany aging. In particular, DNA methylation is one of the best-understood mechanisms, and it has been suggested as a promising biomarker for age estimation in many studies. In this review, we summarize the recent studies on age-associated DNA methylation changes in different tissues and discuss its possible and practical applications in forensics.
Aging
;
DNA
;
DNA Methylation
;
Epigenomics
;
Forensic Sciences
;
Genome
;
Humans