No abstract available.
Humans ; Infant, Newborn*

No abstract available.
Neonatology

We report a case of primary cardiac angiosarcoma in a 35 year-old woman. She presented with dyspnea, facial edema and neck vein distension during 1 month. The oval round large mass(8x4 cm) filling the right atrium infiltrated into the entire thickness of the lateral wall and extended to the vena cava and ventricle. The interatrial septum and pericardium seemed to be intact. Despite the surgical excision and adjuvant chemo-and radiotherapy, the patient died 8 months later due to tumor recurrence. The histologic findings of tumor varied from benign looking capillary proliferation mimicking granulation tissue to sarcoma composed of spindle cells. But anastomosing vascular channels lined by anaplastic polygonal cells and intracytoplasmic lumen containing red blood cells were characteristic findings. These tumor cells showed positive reaction to endothelial cell antigen and factor VIII-related antigen. The intercellular junctional complex and vascular channels formed by cytoplasmic process of tumor cells were identified by the ultrastructural study.
Female ; Humans

Neonatology in pediatrics became a part of medical school curricula in Korea in 1954-1959. Specific treatments and procedures in the neonatal field were adopted around this period, for example, antibiotics, oxygen therapy, and the exchange transfusion procedure were established in 1950-1960. Usage of an infant incubator was implemented along with the establishment in 1960. The trend of separation between a premature infant care unit and newborn nursery room enabled the specialized treatment of high-risk infants in the 1970s. Assisted ventilation with continuous positive airway pressure and phototherapy was initiated in 1978. The recent concept of a neonatal intensive care unit was established in 1980, and it made so-called neonatal intensive care such as mechanical ventilation and intensive monitoring available. The Korean Society of Neonatology was founded in 1993. The usage of pulmonary surfactant in the 1990s, accelerated the improvement of respiratory distress syndrome survival, and it resulted in the nationwide opening of neonatal intensive care unit in hospitals. The high frequency ventilator and inhaled nitric oxide were introduced in the 2000s. The Korean Neonatal Network was commenced as a nationwide systemic database for very low birth weight infant registry in 2010. Accordingly, the history of Korean neonatology can be summarized as 50 years in total, and 35 years in a narrow sense. During this era, neonatal care in Korea has improved remarkably and has achieved a great survival rate for high-risk neonates, preterm infants, and micro-premies. In this review, we intend to provide an overview of the history, efforts, and outcomes of Korean neonatology activity that have led to these achievements.
Anti-Bacterial Agents ; Continuous Positive Airway Pressure ; Curriculum ; Humans ; Incubators, Infant ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care, Neonatal ; Korea* ; Neonatology* ; Nitric Oxide ; Nurseries ; Oxygen ; Pediatrics ; Phototherapy ; Pulmonary Surfactants ; Respiration, Artificial ; Schools, Medical ; Survival Rate ; Ventilation ; Ventilators, Mechanical

We have experienced a patient (4-year-old female) with a granular cell tumor (GCT), Examination of patients skin showed a bean sized asymtomatic firm nodule on the left baek. Exciaional biopsy and histopathologic examination were perforrned under the impression of angiolipoma. The specirnen revealed a distinctive picture of GCT.
Angiolipoma ; Biopsy ; Granular Cell Tumor* ; Humans ; Skin

Authors came acoss a case of Behcet's syndrome involving cecum. The patient was a 33-year-old female. Her chief complaint was right lower quadrant pain, Colonoscopy revealed several ulcerations the base of which was covered by thick whitish coat, They were surrounded by mulitiple nodular masses. Endoscopic biopsy showed noaspecific ulceration. The patient had a history of aphthous ulceration of mouth and external genitalia. So she was diagnosed to have Behcets syndrome. She underwent right hemicolectomy with tetminal ilectomy. We report this case with literiature review.
Adult ; Behcet Syndrome* ; Biopsy ; Cecum* ; Colonoscopy ; Female ; Genitalia ; Humans ; Mouth ; Stomatitis, Aphthous ; Ulcer

PURPOSE: The chest radiograph is useful and reliable in assessing the severity and progression of neonatal respiratory distress syndrome. To evaluate the effect of exogenous surfactant r eplacement therapy, we performed sequential observation of chest radiogratphic findings in neonates with respiratory distress syndrome. METHODS: Two groups of infant with RDS in mechanical ventilation therapy were studied. Surfactant(S-Tx) group(n=36) was treated with Surfactant-TA and control group(n=19) was without use of surfactant. Observation of gestational age, birth weight, clinical severity by ventilatory index, sequential change of radiographic findings and radiological complications in RDS patients were performed. RESULTS: In RDS patients, there was correlation in the radiologic grading and clinical severity. In surfactant treated infants, change of chest radiographic finding was significantly improved than control group. Incidence of pneumothorax and or pulmonary interstial emphysema in S-Tx group was less than that of control group. CONCLUSIONS: Exogenous pulmonary surfactant replacement therapy may contribute the improvement of the clinical and radiological severity and reduction of the incidence of clinical complications. We suggest that surfactant replacement therapy is effective and important useful therapeutic method in neonates with respiratory distress syndrome.
Birth Weight ; Emphysema ; Gestational Age ; Humans ; Incidence ; Infant ; Infant, Newborn* ; Pneumothorax ; Pulmonary Surfactants ; Radiography, Thoracic* ; Respiration, Artificial ; Respiratory Distress Syndrome, Newborn ; Thorax*

PURPOSE: In the case of serious respiratory distress syndrome (RDS) or relapse of clinical appearances after single treatment, we obtained more effective results with multiple-dose surfactant replacement therapy. We carried out this investigation for comparing and observing clinical progress between single-dose (group S) and multiple-dose (group M) pulmonary surfactant treatment group of neonatal RDS. METHODS: We investigated 48 neonates who were diagnosed as RDS and treated with pulmonary surfactant (PS) replacement therapy in NICU of Kyunghee University hospital from January 2002 to March 2004, then we compared and verified clinical progress of 32 neonates in group S with that of 16 neonates in group M. RESULTS: There were no significant statistical differences in average birth weights, average gestational periods, initial pH values of birth, whether operation of resuscitation at that time of birth was made or not, whether prenatal steroid prescription for mother, RDS classification standardized by Bomsel, and ventilation index (VI) before instillation of PS of two groups. However, there was significant statistical difference in a/A PO2 (P< 0.05). We could observe changes of VI and a/A PO2 within 72 hours have been continuously improved at group S rather than group M. In spite of relapses, group M changed for the better after second dose. There were also no significant differences between the two groups in duration of ventilator therapy, mortality within 28 days after birth, intraventricular hemorrhage by complication, retinopathy of premature, necrotizing enterocolitis, chronic lung diseases, sepsis, and DIC. CONCLUSION: In these relapse cases, as there were no significant differences in the mortality rate and the occurence of complication between group S and group M, the requirement of multiple-dose PS replacement therapy which brought improvement of prognosis was emphasized.
Birth Weight ; Classification ; Dacarbazine ; Enterocolitis, Necrotizing ; Hemorrhage ; Humans ; Hydrogen-Ion Concentration ; Infant, Newborn ; Lung Diseases ; Mortality ; Mothers ; Parturition ; Prescriptions ; Prognosis ; Pulmonary Surfactants ; Recurrence ; Respiratory Distress Syndrome, Newborn* ; Resuscitation ; Sepsis ; Ventilation ; Ventilators, Mechanical

We describe a case of successful extracorporeal membrane oxygenation(ECMO) in a small infant with cardiopulmonary resuscitation(CPR) failure after an open heart surgery. A 35-day-old male infant weighing 4.4 kg who had congestive heart failure and pulmonary hypertension underwent patch closure of ventricular septal defect without any intraoperative event. Postoperative course was unremarkable in the intensive care uint for about 5 hours before the junctional ectopic tachycardia developed. Sudden cardiac decompensation with bradycardia occurred about 50 minutes after the development of junctional ectopic tachycardia. He was put on ECMO by arterial cannulation at the ascending aorta and by venous cannulation at the right atrial appendage after 4 hours' CPR. The hemodynamics were stable with enough urine output during ECMO. He was weaned from ECMO 38.5 hours after initiation. Delayed sternal closure was attempted. He was extubated on postoperative day 7 and discharged home on postoperative day 21 without any neurologic sequelae.
Aorta ; Atrial Appendage ; Bradycardia ; Cardiopulmonary Resuscitation* ; Catheterization ; Extracorporeal Membrane Oxygenation* ; Heart Failure ; Heart Septal Defects, Ventricular ; Heart* ; Hemodynamics ; Humans ; Hypertension, Pulmonary ; Infant ; Critical Care ; Male ; Membranes ; Tachycardia, Ectopic Junctional ; Thoracic Surgery*

PURPOSE: To evaluate the various nationwide statistical data for 2002 in Korea and to compare it to statistical data obtained in 1996. METHODS: Questionaires were distributed to 104 hospitals to obtain vital statistics for live-births, their gestational age and birth weight, incidence of preterm infants, low birth weight infants (LBWI), very LBWI (VLBWI), and neonatal mortality for year 2002. RESULTS: Based on 53, 831 inborn and 11, 151 outborn population, from 64 responded hospitals, the incidence of preterm, term, and postterm were 17.5%, 81.4%, and 1.1%, respectively among inborn group. The incidence of preterm among outborn group was lower than that of inborn. The incidences of LBWI, normal birth weight (2.5-4.0 kg) infants, and large birth weight (>4.0 kg) infants were 15.3%, 80.6%, and 4.2%, respectively among inborn group. The incidence of LBWI was lower in outborn group as compared with the inborn group. Overall neonatal mortality rates of preterm, term, and postterm were 5.5%, 0.3%, and 0% and those of LBWI, normal birth weight (2.5-4.0 kg) infants, and large birth weight (>4.0 kg) infants were 6.1%, 0.2%, and 0.1%, respectively. Neonatal mortality rates of VLBWI and extremely LBWI (ELBWI) were 22.5% and 43.9%, respectively. CONCLUSION: Based on statistical data obtained for 2002 from 64 hospitals, the incidence of preterm and LBWI increased, however, the neonatal mortality rates of LBWI and VLBWI declined in 2002 compared to 1996 in Korea. Further continuation of efforts need to be given to improve standarized neonatal care in Korea.
Birth Weight ; Gestational Age ; Humans ; Incidence ; Infant ; Infant Mortality* ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Korea* ; Vital Statistics