No abstract available.
Lymphoma* ; Testis*

No abstract available.
Sinusitis*

No abstract available.
Animal ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; Neurotransmitters/physiology ; Pharmacology, Clinical/trends* ; Receptors, Adrenergic/physiology ; Receptors, Drug/physiology* ; Receptors, Opioid/physiology

No abstract available.
Education, Medical/manpower ; Education, Medical/standards* ; Education, Medical, Graduate/standards ; Education, Premedical/standards ; Korea ; Medicine, Oriental Traditional/standards*

The catecholamine content was examined in the myocardium of dogs subjected to hemorrhagic hypotension of 40mmHg for a duration of one to hive hours respectively. No marked changes were noticed within two hours after production of homorrhagic hypotension but a significant reduction was found at the end of three hours of hypotension. The reduction of myocardial catecholamines was progressively pronounced with the prolonging the hypotensive period over three hours. Dogs were bled rapidly to an arterial blood pressure of 40mmHg and maintained at this hypotensive level for four hours, followed by reinfusion of the withdrawn blood. Eight out of 11 dogs succumbed within l2 hours, showing a 73 per cent mortality. The myocardial catecholamines in the surviving dogs returned almost to the normal level within 12-15 hours after the blood reinfusion, while those in the dogs which succumbed showed the same low level which was produced during hemorrhagic hypotension. It was also shown that the reduced myocardial catecholamines resulting from the hypotension will not be restored immediately after the reinfusion of the withdrawn blood. When norepinephrine was infused at a rate of five to seven microgram/kg/min for an hour before the reinfusion of the withdrawn blood, five out of six dogs died within 12 hours, showing a 82 per cent mortality. This result appears to indicate that norepinephrine infusion during oligemic hypotension may hasten death or not decrease the mortality of the animals. On the other hand, when norepinephrine was infused at a rate of three microgramkg/min for an hour following reinfusion of the withdrawn blood five out of 15 dogs died, indicating a significant increase of survival rate from hemorrhagic shock. The myocardial catecholamines of surviving dogs and dogs which succumbed following the administration of norepinephrine after blood reinfusion were similar respectively to those of dogs which survived and of dogs which died after blood reinfusion without norepinephrine. When norepinephrine (3 microgramkg/min) was infused for hour following blood reinfusion in the dogs pretreated with either dibenzyline (3mg/kg) or dichloroisoproterenol (1mg/kg), the beneficial effect of norepinephrine on the survival rate from hemorrhagic shock appeared to be absent. The efficacy of norepinephrine on the survival from hemorrhagic shock was discussed on the basis of myocardial catecholamine depletion.
Animals ; Catecholamines/*metabolism ; Dogs ; Epiphyses/*embryology ; Myocardium/*metabolism ; Norepinephrine/*pharmacology ; Shock, Hemorrhagic/*drug therapy

It has been known that halothane potentiates the effect of muscle relaxants. We electrophysically studied the atterations by halothane in the rat diaphragm. The diaphragm -phrenic nerve preparation was dissected out of the anesthetized rat. In 1% and 2% halothane groups, control determinations were measured on infusion of simple Ringer's solution. Following infusion of halothane-saturated Ringer's solution for 10 minutes, determinations studied were recorded. Transmembrane currents were elucidated using the standard two microelectrode voltage clamp. To determine the mean MEPC amplitude and , 30 MEPC's were first gotten. A series of EPC's were elicited by stimulation of phrenic nerve at 0.4 Hz and 40 Hz. EPC's of both frequencies were used to evaluate the amplitude and quantum content (QC) of EPC. With tetanic stimulation, the degree of rundown was calculated. 1) MEPC amplitudes were reduced under 1% and 2% halothane, to 80.9% and 71.6% respec- tively. of MEPC shortened to 84.1% and 70.7%. 2) Amplitudes of EPC lowered to 65.9% and 49.4% at 0.4 Hz, and 70.7% and 52.2% at 40 HZ. 3) QC of EPC diminished to 81.5% and 70.1% at 0.4 Hz, and 87.2% and 74.1% at 40 Hz. 4) THe degrees of rundown by the tetanic stimulation were augmented to 119.1% and 136.1%. It is concluded that halothane reduced the amplitude and time constant of decay of MEPC, and the amplitude and QC of EPC, and augmented the degree of rundown at tetanic stimulation.
Animals ; Control Groups ; Diaphragm* ; Halothane* ; Microelectrodes ; Phrenic Nerve ; Rats* ; Synaptic Transmission*

Hypercholesteremia was induced by cholesterol feeding of rabbits for 10 weeks. Gross examination of aorta of these animals showed an evidence of atheromatous lesions. The endogenous catecholamines in heart, adrenal gland, spleen, brain, liver and kidney of these hypercholesteremic rabbits were markedly reduced as compared to those of normal animals, respectively. There may exist some correleration between the serum cholesterol and tissue catecholamines.
Animal ; Arteriosclerosis/etiology* ; Arteriosclerosis/metabolism ; Carbon Isotopes ; Catecholamines/metabolism* ; Cholesterol/blood* ; Female ; Rabbits

No abstract available.
Dilatation* ; Esophageal Perforation*

The gross tissue specimens are a valuable aid to the teaching of pathology and anatomy. However, traditional methods for storage and handling of them are discouragingly difficult and, recently, minimal surgical resections as well as preoperative interventions make it more difficult to have instructive gross specimens. Plastination is a process of tissue preservation by impregnation with silicone polymers or epoxy resins. The process in our study involves dehydration by cryosubstitution in aceton, defatting, forced impregnation of silicon polymer in a vacuum, curing and finishing. We submitted 40 surgically resected specimens to plastination. The resulting specimens are odorless, relatively dry, durable, life-like, non-hazardous, maintenance-free, and do not deteriorate with time. Plastinated specimens are a useful adjunct to the teaching of pathology, particularly suited for use in small groups, and appropriate method of tissue preservation. They are much preferred to wet preparation and conventional pots by both students and teachers owing to their accessibility, superior illustrative powers, and comparative ease of interpretation.
Dehydration ; Epoxy Resins ; Humans ; Pathology* ; Polymers ; Silicones ; Tissue Preservation ; Vacuum

Urinary excretion of 5-hydroxyindoleacetic acid was determined in 114 normal Korean adults and in 110 patients suffering from peptic ulcer. The amount of urinary 5-HIAA excreted during a period of 24 hours is fairly constant in each individual but varies widely between individuals. The mean daily output of urinary 5-HIAA in normal Korean adults is 1.93 +/-0.86 (S.D.) mg, which is similar to that found in normal Chinese adults. There is no significant difference between the urinary excretion of 5-HIAA in normal subjects and in patients with peptic ulcer. Furthermore, the amount of urinary 5-HIAA seems to be influenced by neither the sex of the subject nor by the degree of gastric acidity.
Adult* ; Asian Continental Ancestry Group ; Gastric Acid ; Humans ; Hydroxyindoleacetic Acid ; Peptic Ulcer*