1.Expression of CD34 and β-Catenin in Malignant Rhabdoid Tumor of the Liver Mimicking Proximal-Type Epithelioid Sarcoma
Woo Cheal CHO ; Fabiola BALAREZO
Journal of Pathology and Translational Medicine 2018;52(3):195-197
No abstract available.
Liver
;
Rhabdoid Tumor
;
Sarcoma
2.Crystal-Storing Histiocytosis with Plasma Cell Neoplasm in the Setting of Chronic Carbamazepine Exposure
Woo Cheal CHO ; Safina HAFEEZ ; Peter SHEN
Journal of Pathology and Translational Medicine 2019;53(2):142-144
No abstract available.
Carbamazepine
;
Histiocytosis
;
Neoplasms, Plasma Cell
;
Plasma Cells
;
Plasma
3.The Change of Plasma Concentrations of Fibrinogen Degradation Products and Fibrin Degradation Products During the Open Heart Surgery.
Seong Cheal RYU ; Sung WOO ; Kang Hee CHO ; Yeong Gwon GOO ; Sung Sub PARK
Korean Journal of Anesthesiology 1993;26(3):499-505
There were many researches, which qualitative or quantitative assays were performed about fibrinolysis and the degree of activation of coagulation system. Authors measured fibrinogen degradation products(FbDP) and fibrin degradation products(FbDP) by monoclonal enzymeimmunoassay, instead of polyclonal method in 12 cases of cardiopulmonary bypass(CPB). 1) The increase of FgDP after sternotomy is verifying the significant fibrino(geno) lysis occured by stimulation of sternotomy. 2) By the result that FgDP was significantly increased compared with FbDP, primary fibrinogenolysis is more important phenomenon than secondary fibrinolysis during CPB. 3) FbDP and FgDP were most significantly increased immediately before the end of CPB and after CPB. 4) Increased FgDP was decreased after CPB but FbDP was still elevated 5 hours after CPB. According to the above results, CPB induced primary fibrinogenolysis and secondary fibrinolysis in open heart surgery.
Cardiopulmonary Bypass
;
Fibrin Fibrinogen Degradation Products*
;
Fibrin*
;
Fibrinogen*
;
Fibrinolysis
;
Heart*
;
Plasma*
;
Sternotomy
;
Thoracic Surgery*
4.Rare Manifestations of Churg-Strauss Syndrome with Mediastinal and Hilar Lymphadenopathies: Report of an Autopsy Case
Woo Cheal CHO ; Bharat RAMLAL ; Mary FIEL-GAN ; Xianyuan SONG
Journal of Pathology and Translational Medicine 2019;53(1):66-69
No abstract available.
Autopsy
;
Churg-Strauss Syndrome
5.TRPS1 expression in non-melanocytic cutaneous neoplasms: an immunohistochemical analysis of 200 cases
Yi A. LIU ; Phyu P. AUNG ; Yunyi WANG ; Jing NING ; Priyadharsini NAGARAJAN ; Jonathan L. CURRY ; Carlos A. TORRES-CABALA ; Doina IVAN ; Victor G. PRIETO ; Qingqing DING ; Woo Cheal CHO
Journal of Pathology and Translational Medicine 2024;58(2):72-80
Background:
Although trichorhinophalangeal syndrome type 1 (TRPS1) was initially thought to be highly sensitive and specific for carcinomas and mesenchymal tumors of mammary origin, more recent data suggest its expression is not limited to breast neoplasms but also can be seen in other cutaneous neoplasms, such as extramammary Paget disease and squamous cell carcinoma (SCC) in situ.
Methods:
Two-hundred cases of non-melanocytic cutaneous neoplasm, including basal cell carcinomas (BCCs) (n = 41), SCCs (n = 35), Merkel cell carcinomas (MCCs) (n = 25), and adnexal neoplasms (n = 99), were tested for TRPS1 expression using a monoclonal anti- TRPS1 rabbit anti-human antibody.
Results:
TRPS1 expression was present in almost all cases of SCC (94%), with a median H-score of 200, while it was either absent or only focally present in most BCCs (90%), with a median H-score of 5. The difference between BCCs and SCCs in H-score was significant (p < .001). All MCCs (100%) lacked TRPS1 expression. TRPS1 expression was frequently seen in most adnexal neoplasms, benign and malignant, in variable intensity and proportion but was consistently absent in apocrine carcinomas. All endocrine mucin-producing sweat gland carcinomas (EMPSGCs) (100%, 6/6) showed diffuse and strong TRPS1 immunoreactivity, with a median H-score of 300, which was significantly different (p < .001) than that of BCCs.
Conclusions
Our study shows that TRPS1 may be an effective discriminatory marker for BCCs and SCCs. It also has a role in distinguishing BCCs from EMPSGCs.