No abstract available.
Hemangiosarcoma* ; Neoplasm Metastasis*

No abstract available.
Angiomyoma* ; Mucous Membrane*

No abstract available.
Foot* ; Leg* ; Lichen Planus* ; Lichens*

No abstract available.
Cellulitis* ; Child* ; Eosinophils* ; Humans

No abstract available.
Breast Neoplasms* ; Breast*

No abstract available.
Adenoma, Pleomorphic* ; Lip*

No abstract available.
Immunoglobulin Light Chains* ; Lymphoma, B-Cell, Marginal Zone*

BACKGROUND: The efficacy and safety of daily maintenance treatment with an adapalene-benzoyl peroxide (adapalene-BPO) fixed-dose combination gel is established in acne vulgaris in adults. OBJECTIVE: This study evaluated the efficacy and tolerability of twice-per-week maintenance therapy with an adapalene-BPO combination gel for acne vulgaris in adults. METHODS: All patients applied the adapalene-BPO combination gel once daily during the initial 8 weeks. Subsequently, the patients were randomized into two groups. The maintenance group applied the ointment twice-per-week for 12 weeks of maintenance treatment, while the control group discontinued treatment after the initial 8 weeks active treatment. The changes in the mean numbers of total, inflammatory, and non-inflammatory lesions were assessed. RESULTS: During maintenance treatment, the changes in the average numbers of total and inflammatory lesions in the maintenance group differed significantly from the control group. CONCLUSION: Twice-per-week application of an adapalene-BPO combination gel after active treatment appears to be a good option for the maintenance therapy of acne vulgaris in adults.
Acne Vulgaris* ; Adult* ; Benzoyl Peroxide ; Humans ; Adapalene

Here, we report a case of Cowden syndrome with an unusual clinical course of late-onset oral papillomatosis and a novel germline PTEN mutation. Cowden syndrome is the most common phosphatase and tensin homolog hamartomatous tumor syndrome. It is characterized by multiple hamartomas in the gastrointestinal tract and mucocutaneous lesions such as trichilemmomas, oral papillomatosis, facial papules, and acral keratoses. Patients with Cowden syndrome have a higher risk of malignancies, especially breast, colon, and thyroid cancers. A 53-year-old female presented with cobblestone-like papillomatous papules on the lower gums that developed 1 year earlier. She had no other mucocutaneous lesions besides oral papillomatosis. Gastrointestinal endoscopy and colonoscopy revealed multiple hamartomas in the stomach and colon. The patient had a history of breast cancer and multinodular goiter diagnosed 4 and 5 years ago, respectively. She was diagnosed with Cowden syndrome and a novel PTEN mutation was confirmed by direct sequencing.
Breast ; Breast Neoplasms ; Colon ; Colonoscopy ; Endoscopy, Gastrointestinal ; Female ; Gastrointestinal Tract ; Gingiva ; Goiter ; Hamartoma ; Hamartoma Syndrome, Multiple* ; Humans ; Keratosis ; Middle Aged ; Papilloma ; Stomach ; Thyroid Gland

No abstract available.
Humans ; Scalp*