1.A Case of Prothionamide Induced Hepatitis on Patient with Multi-Drug Resistant Pulmonary Tuberculosis.
Jun Beom PARK ; Byung Hoon PARK ; Ji Young SON ; Ji Ye JUNG ; Eun Young KIM ; Ju Eun LIM ; Sang Hoon LEE ; Sang Kook LEE ; Song Yee KIM ; Wonjai JUNG ; Seungtaek LIM ; Kyung Jong LEE ; Young Ae KANG ; Young Sam KIM ; Se Kyu KIM ; Joon CHANG ; Junjeong CHOI ; Moo Suk PARK
Tuberculosis and Respiratory Diseases 2011;70(3):251-256
The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis.
Biopsy
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Drug-Induced Liver Injury
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Fever
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Hepatitis
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Humans
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Isoniazid
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Korea
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Liver
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Male
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Prevalence
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Prothionamide
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Reference Values
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Rifampin
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Tuberculosis, Multidrug-Resistant
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Tuberculosis, Pulmonary
Result Analysis
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