1.Risk of Stent Stenosis after Implanting a First-Generation Drug-Eluting Stent and Drug Balloon Angioplasty.
Okgeun KIM ; Il RHEE ; Jigeon JANG ; Wonil SONG ; Jonghyun LEE ; Minsung KIM
Korean Journal of Medicine 2015;88(6):690-695
In patients with coronary artery disease, coronary stenting with a drug-eluting stent (DES) is associated with lower rates of in-stent restenosis and re-surgery for the target lesion compared with a bare metal stent, while late stent thrombosis has emerged as a life-threatening complication in patients treated with a first-generation DES. As no treatment has been established for potentially fatal late stent thrombosis associated with a first-generation DES, we perform drug balloon angioplasty for patients with stent thrombosis and in-stent restenosis associated with DES. Here, we reported the cases with normal coronary artery flow after a 2-year follow-up.
Angioplasty, Balloon*
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Constriction, Pathologic*
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Coronary Artery Disease
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Coronary Vessels
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Drug-Eluting Stents*
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Follow-Up Studies
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Humans
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Stents*
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Thrombosis
2.An Exploration of the Neural Network of Lance-Adams Syndrome: a Case Report
Jimin SONG ; Wonil KANG ; Suk Hoon OHN ; Kwang-Ik JUNG ; Shahid BASHIR ; Woo-Kyoung YOO
Brain & Neurorehabilitation 2021;14(1):e1-
Lance-Adams syndrome (LAS) is a rare neurological disorder that may occur after cardiopulmonary resuscitation. The LAS is usually caused by hypoxic changes.Neuroimaging studies show that the brain pathology of LAS patients is not uniform, and the pathophysiology of the myoclonus can vary from patient to patient. Our case study contributes to this etiological heterogeneity by neuroimaging and transcranial magnetic stimulation (TMS). In patients with rare brain conditions such as LAS, a combination of brain stimulation methods, such as TMS, and diffusion tensor imaging can provide insights into this condition's pathophysiology. These insights can facilitate the development of more effective therapies.
3.Effect of Aging on the Pluripotential Capacity of Human Bone Marrow Derived Mesenchymal Stem Cells.
Hye Jin JIN ; Soo Jin CHOI ; Yun Kyung BAE ; Soo Yeun LEE ; Myeong Og GIL ; Chan Mi PARK ; Joon Ho WANG ; Wonil OH ; Yoon Sun YANG ; Inho JO ; Cheol Ki KIM ; Hae Ryong SONG
The Journal of the Korean Orthopaedic Association 2007;42(6):701-710
PURPOSE: The aim of study was to compare the differentiation capacity of mesenchymal stem cells (MSCs) obtained from human bone marrow (BM) according to the age of the donors. MATERIALS AND METHODS: MSCs were isolated from the BM of young (n=16, 12.5+/-5.8 years) and elder (n=4, 48.5+/-7.2 years) patients with the consent of them. We analyzed the cell morphology and the cell surface markers of the MSCs. In addition, we assessed the cell senescence with serial cultures from both age groups. Cell pluripotentiality was analyzed by osteogenic, chondrogenic, and adipogenic induction media. We performed RT-PCR, a measurement of expression of alkaline phosphatase, and staining with von Kossa, safranin O, and oil red O stain. RESULTS: All of the MSC samples tested, irrespective of the age of the donors, MSCs were all successfully isolated from twenty bone marrows. However, the number of cells of from the young donors was five times greater than that of the elderly donors. Senescence was observed over 10 passages in both age groups. The immunophenotypes of both age groups showed similar patterns. MSCs obtained from young and older donors showed the potential to differentiate into osteogenic, chondrogenic, and adipogenic lineages with no difference for both age groups. CONCLUSION: Our study supports that age does not influence the pluripotential capacity of human BM derived MSCs.
Aged
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Aging*
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Alkaline Phosphatase
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Bone Marrow*
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Cell Aging
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Humans*
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Mesenchymal Stromal Cells*
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Tissue Donors