1.The impact of alcohol consumption on hearing loss in male workers with a focus on alcohol flushing reaction: the Kangbuk Samsung Cohort Study
Jaehong LEE ; Youshik JEONG ; Jihoon KIM ; Seonghyeon KWON ; Eunhye SEO ; Jinsook JEONG ; Woncheol LEE
Annals of Occupational and Environmental Medicine 2024;36(1):e1-
Despite hearing loss being a prevalent chronic condition, estimated to nearly 20% of the global population by the World Health Organization, the specific association with individual lifestyle factors, particularly alcohol consumption, remains unclear. In South Korea, approximately 80% of the population engages in alcohol consumption, with a notably high prevalence among males, indicating a high-risk drinking pattern. Therefore, this study aimed to assess the correlation between alcohol consumption and hearing loss in male workers, as well as to analyze additional variables such as alcohol flushing reaction, with the intention of improving worker health. The study was conducted from January 2012 to December 2019, targeting 114,114 participants who visited Kangbuk Samsung Hospital Total Healthcare Centers. Data were collected through pure-tone audiometry tests and alcohol-related questionnaire, and statistical analysis was performed using Cox regression analysis. Based on previous studies indicating a potential protective effect of light drinking on hearing loss, this group was designated as the reference. Additionally, stratified analyses were conducted based on the presence of alcohol flushing reaction and different working hours. The hazard ratio (95% confidence interval) for hearing loss was higher in the heavy drinking group (1.23 [1.11–1.37]) compared to the moderate drinking group (1.09 [0.98–1.20]). Stratified analyses revealed a significantly elevated the hazard ratio of hearing loss in groups with alcohol flushing reaction compared to those without this factor. Our study demonstrated that moderate or heavy alcohol consumption in male workers can increase the risk of hearing loss, particularly in those with alcohol flushing reaction. These findings underscore the importance of addressing alcohol-related factors concerning hearing health among male workers.
2.The impact of alcohol consumption on hearing loss in male workers with a focus on alcohol flushing reaction: the Kangbuk Samsung Cohort Study
Jaehong LEE ; Youshik JEONG ; Jihoon KIM ; Seonghyeon KWON ; Eunhye SEO ; Jinsook JEONG ; Woncheol LEE
Annals of Occupational and Environmental Medicine 2024;36(1):e1-
Despite hearing loss being a prevalent chronic condition, estimated to nearly 20% of the global population by the World Health Organization, the specific association with individual lifestyle factors, particularly alcohol consumption, remains unclear. In South Korea, approximately 80% of the population engages in alcohol consumption, with a notably high prevalence among males, indicating a high-risk drinking pattern. Therefore, this study aimed to assess the correlation between alcohol consumption and hearing loss in male workers, as well as to analyze additional variables such as alcohol flushing reaction, with the intention of improving worker health. The study was conducted from January 2012 to December 2019, targeting 114,114 participants who visited Kangbuk Samsung Hospital Total Healthcare Centers. Data were collected through pure-tone audiometry tests and alcohol-related questionnaire, and statistical analysis was performed using Cox regression analysis. Based on previous studies indicating a potential protective effect of light drinking on hearing loss, this group was designated as the reference. Additionally, stratified analyses were conducted based on the presence of alcohol flushing reaction and different working hours. The hazard ratio (95% confidence interval) for hearing loss was higher in the heavy drinking group (1.23 [1.11–1.37]) compared to the moderate drinking group (1.09 [0.98–1.20]). Stratified analyses revealed a significantly elevated the hazard ratio of hearing loss in groups with alcohol flushing reaction compared to those without this factor. Our study demonstrated that moderate or heavy alcohol consumption in male workers can increase the risk of hearing loss, particularly in those with alcohol flushing reaction. These findings underscore the importance of addressing alcohol-related factors concerning hearing health among male workers.
3.The impact of alcohol consumption on hearing loss in male workers with a focus on alcohol flushing reaction: the Kangbuk Samsung Cohort Study
Jaehong LEE ; Youshik JEONG ; Jihoon KIM ; Seonghyeon KWON ; Eunhye SEO ; Jinsook JEONG ; Woncheol LEE
Annals of Occupational and Environmental Medicine 2024;36(1):e1-
Despite hearing loss being a prevalent chronic condition, estimated to nearly 20% of the global population by the World Health Organization, the specific association with individual lifestyle factors, particularly alcohol consumption, remains unclear. In South Korea, approximately 80% of the population engages in alcohol consumption, with a notably high prevalence among males, indicating a high-risk drinking pattern. Therefore, this study aimed to assess the correlation between alcohol consumption and hearing loss in male workers, as well as to analyze additional variables such as alcohol flushing reaction, with the intention of improving worker health. The study was conducted from January 2012 to December 2019, targeting 114,114 participants who visited Kangbuk Samsung Hospital Total Healthcare Centers. Data were collected through pure-tone audiometry tests and alcohol-related questionnaire, and statistical analysis was performed using Cox regression analysis. Based on previous studies indicating a potential protective effect of light drinking on hearing loss, this group was designated as the reference. Additionally, stratified analyses were conducted based on the presence of alcohol flushing reaction and different working hours. The hazard ratio (95% confidence interval) for hearing loss was higher in the heavy drinking group (1.23 [1.11–1.37]) compared to the moderate drinking group (1.09 [0.98–1.20]). Stratified analyses revealed a significantly elevated the hazard ratio of hearing loss in groups with alcohol flushing reaction compared to those without this factor. Our study demonstrated that moderate or heavy alcohol consumption in male workers can increase the risk of hearing loss, particularly in those with alcohol flushing reaction. These findings underscore the importance of addressing alcohol-related factors concerning hearing health among male workers.
4.Atezolizumab Induced Optic Neuritis and Aseptic Meningitis
Woncheol JEONG ; Sang-Won HA ; Taekyu LIM
Journal of the Korean Neurological Association 2024;42(4):374-377
Immune checkpoint inhibitors (ICIs) are widely used in cancer treatment due to their efficacy and relatively low toxicity. ICIs have fewer side effects than conventional chemotherapy but can cause significant immune-related adverse effects by overstimulating the immune system. Among them, neurological immune-related adverse events are rare but can be serious side effects. The authors report a case of a patient treated with atezolizumab, a type of ICI, who experienced the rare side effects of optic neuritis and aseptic meningitis simultaneously.
5.Atezolizumab Induced Optic Neuritis and Aseptic Meningitis
Woncheol JEONG ; Sang-Won HA ; Taekyu LIM
Journal of the Korean Neurological Association 2024;42(4):374-377
Immune checkpoint inhibitors (ICIs) are widely used in cancer treatment due to their efficacy and relatively low toxicity. ICIs have fewer side effects than conventional chemotherapy but can cause significant immune-related adverse effects by overstimulating the immune system. Among them, neurological immune-related adverse events are rare but can be serious side effects. The authors report a case of a patient treated with atezolizumab, a type of ICI, who experienced the rare side effects of optic neuritis and aseptic meningitis simultaneously.
6.Atezolizumab Induced Optic Neuritis and Aseptic Meningitis
Woncheol JEONG ; Sang-Won HA ; Taekyu LIM
Journal of the Korean Neurological Association 2024;42(4):374-377
Immune checkpoint inhibitors (ICIs) are widely used in cancer treatment due to their efficacy and relatively low toxicity. ICIs have fewer side effects than conventional chemotherapy but can cause significant immune-related adverse effects by overstimulating the immune system. Among them, neurological immune-related adverse events are rare but can be serious side effects. The authors report a case of a patient treated with atezolizumab, a type of ICI, who experienced the rare side effects of optic neuritis and aseptic meningitis simultaneously.
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