Psoriasis is one of the relatively common cutaneous disorders, affecting 0.1% to 3.0% of the general population in the world. However, it is recorded that the disease is characterized by its highly variable clinical manifestations and incidence influenced by the racial, geographic and environmental factors. There is a dearth of information for the incidence and clinical manifestations of psoriasis, with the exception of two small-scale and one questionnaire surveys in Korea. This study was aimed to investigate the clinical manifestations and clinic incidence of psoriasis and was based on analysis of 301 psoriatics seen between January, 1978 and August, 1981 (3 years and 8 months) at the Department of Dermatology, Seoul National University Hospital. The results were summarized as follows; 1. In this series of 301 patients, 50.5%(152) were male and 49.5%(149) were female. No significance was attached to the sex preponderance. More than three quarters were aged between 20 and 29 years. 2. The mean age of onset in male was 25.7 years and in female it was 23.0 years, indicating a slightly earlier onset in female. The peak age of incidence in male was between 20 and 29 years and in female, between 10 and 19 years. 3. The mean duration of t.he diseases for the total sample was 7.9 years.
Female ; Male ; Humans ; Incidence

It is generally believed that the defense against mycobacterium leprae is largely mediated through cell-mediated immunity(CMI) and several investigators have reported a defective CMI in patients with leprosy. especially the lepromatous from. This study was undertaken to ennumerate the peripheral T-cell population in leprosy patients for evaluation of one aspect of its immune status. Fiftu-two patients with leprosy(26 tuberculoid, 17 active lepromatous, 9 inactive lepromatous) entered in this study. All the patients are under regular antileprosy chemotherapy for varing periods(10 months to 14 years). Peripheral blood T0lymphocytes were enumerated by the E-rosette technique and compared with normal healthy control. The results were as follows: The mean T-cell percentage in peripheral blood was 50.6% in 17 active lepromatous leprosy patients, 62.2% in 9 inactive lepromatous leprosy patients, 67.7% in 26 tuberculoid patients and 69.5% in 17 normal healthy controls, There was marked decrease in the peripheral T-cell ratio in active lepromatous group (p<0,005) and less marked decrease in inactive lepromatous group (0.01.
Drug Therapy ; Humans ; Leprosy* ; Leprosy, Lepromatous ; Mycobacterium leprae ; Research Personnel ; T-Lymphocytes

This study was done to investigate some selected epidemiological characteristics of accidents occured in the closed-ward of a psychiatric hospital in Seoul during one year period from Jan. 1, 1993 toDec. 31, 1993. For this study, 1,570 accidents(702 patients) reported from 1,833 discharged patients were analysed. Major findings obtained from this study were as follows; 1. Prevalence rate of the accidents were 38 persons per 100 discharged pateints and 86 accident spells per 100 discharged patients. 2. The highest risk of accident was noticed in the group of male, 20-29 age, middle school graduate, and divorced. 3. By diagnostic category, accident rates per 100 discharged patients were 339 spells in seizure disor-der, 102 in substance abuse, 93 in schizophrenia, 69 in alcoholism, and 61 in mood disorder. 4. By the period, the accident rate was higher within I month after admission, and the rate was higher in April and November, Wednesday, the day of family visiting, and during day time. 5. Accident types were violent behavior(53%), alcohol drinking(12%), emergency for physical episode(9%), elopement(7%), property damage (5%), self-inflicted injury and suicidal attempt (4%). Severity of damage was usually minimal, and the persons who were commonly involved in the accidents were the petients rather than him self and therapist.
Alcoholism ; Divorce ; Emergencies ; Epidemiologic Studies* ; Hospitals, Psychiatric* ; Humans ; Male ; Mood Disorders ; Prevalence ; Schizophrenia ; Seizures ; Seoul ; Substance-Related Disorders

No abstract available.
Venous Thrombosis

Adenomyotic cyst is very rare disease, their sizes are mostly lesser 5mm. The intrauterine adenomyotic cyst may arise from progressive expansion of cyst due to progressive menstrual bleeding. Authors experienced a case of large adenomyotic cyst within myometrium occuring in a l9-year-old woman, and who was accompanied with endometriosis. The cyst was about 3 x 3em sized, and had chocolate colored thick viscous contents, We experienced one case of adenomyotic cyst which was thought to be degenerated uterine myoma, so we report the case with a brief review of the concerned literatures.
Animals ; Cacao ; Endometriosis* ; Female ; Hemorrhage ; Humans ; Leiomyoma ; Mice ; Myometrium* ; Rare Diseases

BACKGROUND: The regional fat distribution is known to be related with some cardiovasular risk factors independently to total body fat amount. Regional fat distribution pattern can be assessed by waist to-hip ratio(WHR). WHR distribution patterns depend on age, sex, race and show regional difference. But, our own unique data are inadequate, so we tried to investigate distribution patterns, cut off points and related factors of WHR in middle aged men and women among Korean. METHODS: The study population were middle aged men and women above 40 years old who visited our hospital for routine check up from April to July, 1996. We measured height, weight, blood pressure, waist circumference, hip circumference, fasting blood sugar and total cholesterol in 1,000 persons. We gathered data about diet habits, exercise, smoking and drinking status by standard questionnaire. We analized above data by using SAS for Window 6.10. RESULTS: The study population numbers of men and women were 494 and 499, and average ages of men and women were 49.3 and 50.5 years respectively. For men, the average WHRs as a whole were 0.895, and 0.893, 0.893 and 0.911 in their forties, fifties and above sixties respectively. For women, the average WHRs as a whole were 0.827, and 0.816, 0.837 and 0.850 in their forties, fifties and above sixties respectively. The percentage above WHR 1.0, 0.95, and 0.90 in men were 2.4%, 11.7% and 46% and the percentage above WHR 0.90, 0.85, and 0.80 in women were 8.2%, 32.9% and 68.7%. Adjusting by age, body mass index, WHR was significantly correlated with weight, systolic blood pressure, diastolic blood pressure in men only. For men, WHR was associated with alcohol drinking positively and with exercise negatively. For women, WHR was associated with alcohol drinking and smoking status positively. CONCLUSIONS: The WHR had a tendency to increase according to age. The 90th percentile points in men and women were 0.957 and 0.894 respectively. WHR was related with several cardiovascular risk factors and several life styles.
Adipose Tissue ; Adult ; Alcohol Drinking ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Cholesterol ; Continental Population Groups ; Drinking ; Fasting ; Female ; Food Habits ; Hip ; Humans ; Life Style ; Male ; Middle Aged* ; Risk Factors ; Smoke ; Smoking ; Waist Circumference ; Waist-Hip Ratio* ; Surveys and Questionnaires

BACKGROUND: The human homologue of the SC2 gene from a human dermal papilla cell cDNA library has been isolated and designated hSC2. HSC2 protein also shares similarity with 5 -reductase, a protein important in testosterone metabolism. OBJECTIVE: Prior to knowing the functions of hSC2 in dermal papilla, we cloned it and analyzed its relative expression levels in adult tissues and cancer cell lines. METHODS: hSC2 was isolated from low abundant clones in dermal papilla cDNA library using cDNA array hibridization method. Full-length clone was sequenced and we studied its expression in different tissues by Northern blot hybridization. RESULTS: Sequence data reveals a single open reading frame, encoding a putative hydrophobic protein with a calculated molecular weight of 36 kDa. Its deduced amino acid sequences are almost 97.4% identical to t4ose of rat protein. Northern blot hybridization shows that hSC2 cDNA recognizes a 1.35 kb transcript that was expressed in various epithelial and mesenchymal tissues including testis and liver. CONCLUSION: We have cloned and analysed tissue distributions of hSC2. It was interesting that it had homology with 5α-reductase isozymes. Further studies will be needed to understand the involvement of hSC2 in androgen hormone signaling.
Adult ; Amino Acid Sequence ; Animals ; Blotting, Northern ; Cell Line ; Clone Cells ; Cloning, Molecular* ; DNA, Complementary ; Gene Library ; Humans ; Isoenzymes ; Liver ; Metabolism ; Molecular Weight ; Oligonucleotide Array Sequence Analysis ; Open Reading Frames ; Rats ; Testis ; Testosterone ; Tissue Distribution

The second case of this serial reports under the title of unusual cutaneous manifestations of connective tissue diseases is a woman with primary idiopathic dermatomyositis who developed cutaneous ulcerations on her arms and legs, which is thought to b a rare manifestation of adult dermatomyositis. These multiple ulcerations are about bean sized, polymorphous, and grouped on the poikilodermatous lesional skin. In this patient these ulcerative lesions became regressive and healed with disfiguring scars after the activity of the disease has controlled by prednisolone and methotrexate.
Adult ; Arm ; Cicatrix ; Connective Tissue Diseases* ; Connective Tissue* ; Dermatomyositis* ; Female ; Humans ; Leg ; Methotrexate ; Prednisolone ; Skin ; Ulcer*

No abstract available.
Pulmonary Embolism*

The purpose of this study was to investigate what the intermediate filaments in the cells of rat mandibular fossa fibrous layer are and any relationships between the presence of these filaments and aging. Mandibular fossae of 4 groups of rats(14-day, 28-day, 55-day and adult groups) were removed on bloc and processed for immunostaining and were subjected to light microscopic examination. The results were as follows : In 14-day group, there were no immunoreactive cells in fibrous layer of mandibular condyle articular surface. But in 28-day group, many immunoreactive cells were seen in fibrous layer, especially central portion of articular surface of mandibular fossa. These cells were fusiform shaped and immunoreactivities were seen in the cytoplasm around the nucleus. In 55-day group many immunoreactive cells were seen in fibrous layer of mandibular fossa. These cells were fusiform shaped and distributed evenly in central portion of this fibrous layer. Immunoreactivities were seen in the cytoplasm around the nucleus. In adult group, the results were similar to 55-day group, Many immunoreactive cells were seen in fibrous layer of mandibular fossa especially central portion. According to these results, vimentin immunoreactive filaments appear with aging and increment of mechanical load associated with incision or mastication.
Adult ; Aging* ; Animals ; Cytoplasm ; Humans ; Intermediate Filaments ; Mandibular Condyle ; Mastication ; Rats* ; Vimentin*