1.The first case of human infection with tapeworms of the genus Mesocestoides in Korea.
Won Young CHOI ; Byong Chil KIM ; Hyon Suk CHOI
The Korean Journal of Parasitology 1967;5(1):60-64
The infection with tapeworm of the Mesocestodes sp. has been rarely reported and only 8 cases of human infection were found in the world up to date. This is to report the first case of human infection with this tapeworm belonged to Cyclophyllidea in Korea. In January 1967, a 45 years old man visited to the out clinic of St. Mary's Hospital with the complaints of intermittent indigestion and abdominal distension nearly for 1 year. Laboratory findings appeared almost normal except increased eosinophils up to 14 per cent. The characteristic ova of Mesocestoides sp. were found by the serial stool examinations, which contained hexacanth larva inside the egg shell without operculum as in Cyclophyllidea. It was failed to reveal the scolex by the first evacuation, but one among 3 worms evacuated by the treatment with atabrine and enough purgations 2 months later, has been found the characteristic scolex. They were 85 cm to 136 cm long and the scolex had 4 distinct suckers but no rostellum, the matured proglottid had numerous testes bilaterally and ovary with yolk glands in central parts, and in the gravid proglottid spiral uterus was opened to uterine pore and characterized by the spherically distended uterine capsules. The patient had the history of ingestion of 15 snakes as raw about 1 year ago as usually seen in Japanese cases.
parasitology-helminth-cestoda-Mesocestodes sp.
;
case report
2.A Study on the Effect of Topical Indomethacin on Sunburn.
Jong Sung CHOI ; Won Suk KIM ; Yoo Shin LEE
Korean Journal of Dermatology 1978;16(3):181-189
It is generally recognized that several chemical mediators are involved in tbe pathogenesis of sunbum; however, the exact mechanism is still to he resolved. Recently, prostaglandin has been found to be one of the inflammatory mediators in sunbum, particularly in the delayed erythema response and several investigators have shown that the nonsteroidal antiinflammatory drugs inhibit the in vivo synthesis of prostaglandin. On the assumption that the nonsteroidal antiinflammatory drugs might exert a beneficial effect on the sunbum through the antiprostaglandin effect, several authors have reported the effect of indomethacin on sunbum. This study was undertaken to evaluate the effect of topical indomethacin on the delayed erythema response induced by artificial sunlamp and sunlight by clinical and histopathological examination. Indomethacin(2. 5% ointment, 2. 5% solution, 5% solution) was applied immediately after 3 MED irradiation of artificial sunlamp to the shaved back skin of 6 healthy albino guinea pigs weighing 550-850gm and 9 human volunteers and the delayed erythema response was observed at 2, 4, 6, 12, 24 and 48 hours after irradiation respectively. Punch biopsies of the skin were performed on 6 guinea pigs at 6, 12, 24 a.nd 48 hours after irradiation and the histologic changes were observed. Four human volunters were exposed t,o 3 MED of sunlight and indomethacin preparations were applied immediately after irradiation. The delayed erythema response was observed at 2, 4, 6, 12, 24 and 48 hours postirradiation and in one volunteer, the skin was biopsied at 24 hour for histologi.c evaluation. The results were as follows: 1. Topical indomethacin in ointment or solution forms delayed and decreased the appearance and degree of erythema induced by sunlight and artificial sunlamp in both human and animal subjects. 2. Histologically, the number of sunbum cells at 24 hour in the epidermis of one human volunteer was decreased on indomethacin applied sites. The dermis showe6 no difference in histologic changes between control and indomethacin sitea. In animal study, however, no detectable difference in epidermal or dermal changes was observed between control and indomethacin applied sites. The autors confirmed that topical indometha,cin was effective in delaying and blanching of the delayed erythema of sunbum in guinea pigs as well as in human volunteers, though there was no difference in histologic changes between indomethacin and control sites in guinea pigs. The mechanism involvel on this aspect is remained to be resolved.
Animals
;
Biopsy
;
Dermis
;
Epidermis
;
Erythema
;
Guinea Pigs
;
Healthy Volunteers
;
Humans
;
Indomethacin*
;
Research Personnel
;
Skin
;
Sunburn*
;
Sunlight
;
Volunteers
3.Frozen Section: Application in the Surgical Pathology.
Won Hee CHOI ; Tae Sook LEE ; Suk Jae HONG
Yeungnam University Journal of Medicine 1986;3(1):179-183
The frozen section technique is a means of intraoperative pathological diagnosis, and a procedure of great value to the surgeon. This method should be accurate, rapid and reliable. This method serves useful purposes, such as determining the presence of tumor, its type (especially whether it is benign or malignant), the adequacy of a biopsy of a suspected lesion, and the conditions of the surgical margins. But, it bears many disadvantages, the most of which is the danger of incorrect diagnosis. We studied the indications, the limitations, and the accuracy of the frozen section method and the materials studies was total of frozen section diagnosis of 809 cases was 98.1% with 0.5% of false negative, 0% of false positive 0.5% of incorrect histological diagnosis or grading errors, and 0.9% of deferred cases. The tissues submitted were lymph node, gastrointestinal tract, skin subcutaneous tissues in decreasing oder of frequency. The false positive case is not present, while the false negative cases were 4.
Biopsy
;
Diagnosis
;
Frozen Sections*
;
Gastrointestinal Tract
;
Lymph Nodes
;
Methods
;
Pathology, Surgical*
;
Skin
;
Subcutaneous Tissue
4.Histopathological Studies on Tumors of Testis in the Taegu Area.
Suk Jae HONG ; Tae Sook LEE ; Won Hee CHOI
Yeungnam University Journal of Medicine 1987;4(2):149-154
For evaluation on the histopathologic studies and age distribution of the testicular tumors in the Taegu area, the inguinal orchidectomized materials were collected at the Department of Pathology, College of Medicine, Yeungnam University, and the analyzed results were as follows: 1. In total of 11 cases of orchidectomized materials, germ cell tumors are 10 cases (90.9%). In germ cell tumors according to the histologic types, seminoma was 5 cases (45.5%), and embryonal carcinoma, 3 (27.2%). 2. The highest age incidence of the group is 20th and 30th, and the next, 50th and 10th.
Age Distribution
;
Carcinoma, Embryonal
;
Daegu*
;
Incidence
;
Neoplasms, Germ Cell and Embryonal
;
Pathology
;
Seminoma
;
Testicular Neoplasms
;
Testis*
5.The Effects of Basic Fibroblast Growth Factor(bFGF)on Type I and VII Collagen Gene Expression in Cultured Dermal Fibroblast.
Young Wook RYOO ; Dong Won CHOI ; Kyu Suk LEE
Annals of Dermatology 1999;11(3):147-152
BACKGROUND: bFGF, a member of the fibroblast growth factor family, potently induces vascular smooth muscle cell proliferation and decreased synthesis of the collagens. OBJECTIVE: For further investigation of the effect of bFGF on extracellular matrix homeostasis in the skin, we evaluated the expression of type I and type VII collagen gene at the transcriptional levels. METHOD: We examined that recombinant human bFGF affects the expression of genes involved in ECM synthesis and remodeling in human dermal fibroblasts cultures as judged by Northern blot analysis. RESULTS: The steady state levels of type I and VII collagen gene mRNA were decreased with age dependent pattern up to 0.13 and 0.44 folds respectively. The transcriptional levels of type I collagen mRNA were increased by TGF-B, treatment but markedly decreased by bFGF as well as TNF-a. But there were no synergistic effects bFGF and TNF-a on type I collagen gene expression. The levels of type VII collagen gene expression were increased by both bFGF and TGF-B,. The TNF-a showed slightly antagnostic effects on type VII collagen gene expression. CONCLUSION: The type I and VII collagen gene expression in dermal fibroblasts is clearly subjected to modulation by the cytokines including bFGF with uncoordinate regulatory pathway. In addition to its function of vascular proliferation, bFGF also may play a major role in physiologic skin condition and in repair process such as formation of a stable dermoepidermal junction during skin wound healing.
Blotting, Northern
;
Cell Proliferation
;
Collagen Type I
;
Collagen Type VII
;
Collagen*
;
Cytokines
;
Extracellular Matrix
;
Fibroblast Growth Factors
;
Fibroblasts*
;
Gene Expression*
;
Homeostasis
;
Humans
;
Methods
;
Muscle, Smooth, Vascular
;
RNA, Messenger
;
Skin
;
Wound Healing
6.A Case of Mucocutaneous Lymph Node Syndrome Complicated by Partial Intestinal Obstruction.
Dong Won CHOI ; Ki Sup CHUNG ; Jin Suk SUH
Journal of the Korean Pediatric Society 1988;31(6):796-802
No abstract available.
Intestinal Obstruction*
;
Mucocutaneous Lymph Node Syndrome*
7.Clinical and Histopathological Studies on Carcinoma of the Uterine Cervix in Taegu.
Joon Hyuk CHOI ; Won Hee CHOI ; Suk Jae HONG ; Tae Sook LEE
Yeungnam University Journal of Medicine 1988;5(2):121-128
Clinical and histopathological studies were made on 202 cases of malignancy of cervix, that were visited to the Department of Obstetrics and Gynecology, Yeungnam University Hospital, during 5 years from 1983 to 1987. The results were summarized as follows. 1. Malignancies of the uterine cervix were 10% of total female malignancies. 2. Among 202 cases, 195 cases (96.5%) were squamous cell carcinoma, in which 60 cases (30.0%) of carcinoma in situ, 9 cases (4%) of microinvasive, and 126 cases (62.5%) of invasive carcinoma were included. 3. The average age of the patients with squamous cell carcinoma was 49.4 years old; In case of carcinoma in situ, it was 43.8, microinvasive, 40.0, invasive 52.1 years old. 4. Clinical symptoms of the patient with squamous cell carcinoma in order of frequency were as follows; vaginal bleeding (47.5%), abnormal cytology (15.4%), and abnormal vaginal discharge (9.4%). 5. Duration of the chief complaints was most commonly less than 6 months (73.2%), and the average duration was 3.8 months. 6. The most common age of marriage was between 19 to 22 years old (46.5%). The average was 21.5 years old. 7. The gravity was 51.5% in 5-8 times, and average 6.2 times. The parity was 61.9% in 1-4 times, and average 3.9 times. 8. The subdivision of 126 cases of invasive carcinoma was made according to FIGO stage classification, stage I, 40 cases (31.8%), stage II, 54 cases(42.9%), stage III, 11 cases (8.7%), and stage IV, 8 cases (6.3%). 9. The histologic subtypes of invasive squamous cell carcinoma were distributed as follows; large cell keratinizing type, 25 cases (19.8%), large cell nonkeratinizing type, 101 cases (80.2%). 10. In the cytologic diagnosis, class I was 2 cases (1.9%), class II was 16 cases (15.1%), class III was 33 cases (31.1%), class IV was 31 cases (29.3%), class V was 24 cases (24.6%). 11. The frequency of lymph node metastasis was 7.5% in stage I, and 11.1% in stage II.
Carcinoma in Situ
;
Carcinoma, Squamous Cell
;
Cervix Uteri*
;
Classification
;
Daegu*
;
Diagnosis
;
Female
;
Gravitation
;
Gynecology
;
Humans
;
Lymph Nodes
;
Marriage
;
Neoplasm Metastasis
;
Obstetrics
;
Parity
;
Uterine Hemorrhage
;
Vaginal Discharge
8.Regenerate Bone Healing According to Osteotomy Methods in Ilizarov lengthening
Ik Su CHOI ; Oh Young KWON ; Cheol Ho KWAK ; Won Suk CHOI ; Su In ROH
The Journal of the Korean Orthopaedic Association 1996;31(5):1090-1098
The Ilizarov technique for gradual distraction osteogenesis was developed in the 1950s. A correctly performed osteotomy is essential to the success of distraction osteogenesis and prepares for limb lengthening. Between Sept. of 1991 and 1994, thirty-four patients were treated by Ilizarov technique at St. Benedict Hosp. and Gang-Dong Hosp.. And then assigned to two separate groups : a corticotomy group (group A) and osteotomy group (group B; osteotomy with Gigli saw or osteotomy with multiple drill holes and osteotome). The regenerate segments were evaluated weekly for the first six weeks after operation. After the initial six-week evaluation period, observations of these segments were continued through a series of monthly radiographs. Distraction began on postoperative day seven in group A and on day eleven in group B; and continued at a rate of 1 mm/day and a frequency of 4 times/day. Group A displayed new bone formation earlier than group B: group A's mean was 16.5 ± 4.9 days, while B's mean was 25.3 ± 4.6 days. The first bridging callus occurred earlier in group A than it did in group B: A's mean was time of 36.7 ± 9.9 days, while B's mean was 44.0 ± 7.9 days. There was no significant difference between groups A & B in terms of first cortical formation : A's mean was 86.9 ± 24.0 days, and B's mean was 100.6 ± 25.2 days. There was no significant difference between groups A & B in terms of the bone healing index : A's mean was 41.6 ± 13.5 days and B's mean was 41.15 ± 8.10 days.
Bony Callus
;
Extremities
;
Humans
;
Ilizarov Technique
;
Methods
;
Osteogenesis
;
Osteogenesis, Distraction
;
Osteotomy
9.Effect of ondansetron in prevention of nausea and vomiting associated with cisplatin chemothrapy in cancer patients.
Sang Won SHIN ; Kyung Mook CHOI ; Jong Eun YUN ; Sang Myun PARK ; Chul Won CHOI ; Joon Suk KIM
Journal of the Korean Cancer Association 1993;25(2):299-306
No abstract available.
Cisplatin*
;
Humans
;
Nausea*
;
Ondansetron*
;
Vomiting*
10.A Case of Hemorrhagic Angiodysplasia of the Duodenal Bulb in a Patient under Chronic Hemodialysis.
In Sik CHUNG ; Boo Sung KIM ; Suk Won HAN ; Kyu Yong CHOI ; Myung Gyu CHOI ; Young Suk LEE ; Jong Young CHOI ; Nam Ik HAN
Korean Journal of Gastrointestinal Endoscopy 1994;14(3):374-379
Upper gastrointestinal tract angiodysplasia is rare, but it is an important cause of upper gastrointestinal bleeding. We experienced a case of hemorrhagic angiodysplasia of duodenal bulb in a patient under chronic hemodialysis due to chronic renal failure. Repeated upper GI endoscopy revealed an angiodysplasia at the posterior wall of the duodenal bulb. It was successfully treated by bipolar electrocoagulation. We report a case of angiodysplasia in chronic renal failure patient with the review of the literatures.
Angiodysplasia*
;
Electrocoagulation
;
Endoscopy
;
Hemorrhage
;
Humans
;
Kidney Failure, Chronic
;
Renal Dialysis*
;
Upper Gastrointestinal Tract