No abstract available.
Seoul*

PURPOSE: The purpose of this study was to investigate health management state during pregnancy, childbirth, and postpartum of immigrant women. METHODS: A descriptive research design was employed. Data were collected from 182 immigrant women who lived in four provinces and D city. Subjects were completed the following questionnaires: demographic, medical service use, pregnancy and childbirth, and health management during the ante-postpartum. RESULTS: The average age of subjects was 28.96 and 83 subjects (45.6%) were coming from Vietnam. 55 Subjects (30.2%) were within the low-income group with less than 4 million won per month. So, 62 subjects were uninsured women because of the expensive costs. Subjects mainly visited a health care center with their husband. On the using a health care center, subjects complained about communication difficulties and transportation problems. 42 Subjects were pregnant but 21.4% of pregnant subjects did not receive antenatal care. Subjects got information about pregnancy and childbirth through their husbands and husband's family. CONCLUSION: Nursing intervention to manage the pregnancy, childbirth, and the postpartum of immigrant women need to be developed and should include strategies to take care of themselves after delivery and provide knowledge and information about ante-postpartum.
Cultural Diversity ; Delivery of Health Care ; Delivery, Obstetric ; Emigrants and Immigrants ; Female ; Humans ; Medically Uninsured ; Parturition ; Postpartum Period ; Pregnancy ; Research Design ; Spouses ; Transportation ; Vietnam

Neuroleptic malignant syndrome (NMS) is a rare, but a potentially life threatening condition associated with the use of antipsychotics. The most frequent signs and symptoms of NMS include fever, muscle rigidity, autonomic dysfunction such as tachycardia, tachypnea, and labile blood pressure. Acute complications of NMS include disseminated intravascular coagulation, sepsis, seizure, myocardial infarction, acute renal failure due to rhabdomyolysis and death. We report a rare case of acute renal failure due to rhabdomyolysis associated with neuroleptic malignant syndrome.
Acute Kidney Injury ; Antipsychotic Agents ; Blood Pressure ; Disseminated Intravascular Coagulation ; Fever ; Muscle Rigidity ; Myocardial Infarction ; Neuroleptic Malignant Syndrome ; Rhabdomyolysis ; Seizures ; Sepsis ; Tachycardia ; Tachypnea

-D- is a very rare haplotype which determines D without C, c, E or e and exalted D activity. The extremely rare homozygote propositi(-D-/-D-) are usually ascertained through their immune antibodies which react with red cells of all common Rh phenotypes. Authors experienced a woman with -D- phenotype for the first time in Korea. She had a history of abortion and intrauterine fetal death. She delivered a baby with severe hemolytic disease of the newborn at the third pregnancy. In spite of intensive medical interventions, the baby died of hydrops fetalis. An immune antibody to high incidence Rh antigen, namely anti-Hro, was demonstrated in the woman's serum. Family study revealed that all of the family had -D- gene complex and one of her sisters also was -D-homozygote. The sister also had anti-Hro in the serum.
Antibodies ; Female ; Fetal Death ; Haplotypes ; Homozygote ; Humans ; Hydrops Fetalis ; Incidence ; Infant, Newborn* ; Korea ; Phenotype* ; Pregnancy ; Siblings

PURPOSE: The purpose of this study was to determine the clinical value of bicarbonate gap (BG) in acute gastroenteritis by comparison of clinical manifestations and laboratory findings. METHODS: We retrospectively analyzed 135 patients who had acute gastroenteritis. We classified them into two groups: BG< or =-5 (group A), BG>-5 (group B). We made a comparative study for clinical manifestations, serum electrolyte, albumin, protein, blood urea nitrogen (BUN), creatinine, anion gap (AG), delta anion gap (deltaAG) and delta bicarbonate (deltaHCO3-) between the two groups. RESULTS: The duration of hospitalization and diarrhea was significantly longer in group A than group B. In laboratory findings, serum sodium, serum total CO2, total protein, AGcorrected and deltaAG were lower in group A than group B. deltaHCO3- and chloride were higher in group A than group B. CONCLUSION: BG may be a sensitive predictor enough to access the severity of acute gastroenteritis.
Acid-Base Equilibrium ; Acidosis ; Blood Urea Nitrogen ; Creatinine ; Diarrhea ; Gastroenteritis ; Hospitalization ; Humans ; Retrospective Studies ; Sodium

PURPOSE: To determine the factors that affect glaucomatous change and the clinical course of patients with Posner-Schlossman syndrome. METHODS: A retrospective analysis of 52 eyes of 51 patients who had been diagnosed with Posner-Schossman syndrome between January 1995 and June 2003 was performed. We analysed the factors by the age of onset, the duration of disease, the number of attacks, the highest intraocular pressure, the cup/disc ratio of affected eye and unaffected fellow eye during attacks, and visual field change. RESULTS: Twelve (23.1%) of 52 eyes revealed significant glaucomatous change. The number of attacks showed statistically significant difference between the two groups who had developed glaucoma and who had not (P=0.021). But the age of onset, the duration of disease, and the highest intraocular pressure during attack did not show statistically significant difference (P>0.1). CONCLUSIONS: From this study, we observed that the only factor influencing glaucomatous change in patients with Posner-Schlossman syndrome was the number of attacks. So in case of recurrent attacks, close observation and aggressive treatment is mandatory.
Age of Onset ; Glaucoma ; Humans ; Intraocular Pressure ; Retrospective Studies ; Visual Fields

Human follicular fluid (HFF) includes various biologically active proteins which can affect follicle growth and oocyte fertilization. Thus far, these proteins from mature follicles in human follicular fluid have been poorly characterized. Here, two-dimensional polyacrylamide gel electrophoresis (2-DE) with matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) was used to identify new proteins in HFF. Mature follicular fluids were obtained from five females after oocyte collection during in vitro fertilization (IVF). We directly rehydrated HFF samples, obtained high-resolution 2-DE maps, and processed them for 2-DE and MALDI-MS. One hundred eighty spots were detected and 10 of these spots were identified. By the 2-DE database, six of them had been reported, as proteins already existing in HFF. Hormone sensitive lipase (HSL), Unnamed protein product 1 (UPP1), Unnamed protein product 2 (UPP2), and apolipoprotein A-IV precursor were newly detected. HSL and apolipoprotein A-IV participate in lipid metabolism. UPP1 has a homology with selenocysteine lyase. We found by RT-PCR that these genes are expressed from human primary granulosa cells. The proteins identified here may emerge as potential candidates for specific functions during folliculogenesis, hormone secretion regulation, or oocyte maturation. Further functional analysis of these proteins is necessitated to determine their biological implications.
Adult ; Electrophoresis, Gel, Two-Dimensional/*methods ; Female ; Follicular Fluid/*chemistry/metabolism ; Gene Expression ; Granulosa Cells/metabolism ; Humans ; Ovarian Follicle/*chemistry/metabolism ; Proteins/*analysis/genetics ; RNA, Messenger/genetics/metabolism ; Research Support, Non-U.S. Gov't ; Reverse Transcriptase Polymerase Chain Reaction ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

OBJECTIVE: To investigate the association of genetic background between MTHFR C677T genotype and infertile females with polycystic ovarian syndrome. MATERIALS AND METHODS: We compared 86 infertile females with polycystic ovarian syndrome (PCOS) with 100 healthy fertile females with one or more offspring. Pyrosequencing analysis for MTHFR C677T variation was performed on polymerase chain reaction (PCR) product of study group. To validate pyrosequencing data of C677T variation for randomly selected 50 samples, we compared the pyrosequencing result with the PCR-RFLP (Restriction Fragment Length Polymorphism) result of MTHFR C677T genotype. RESULTS: The prevalence of the C677T mutant homozygous (TT) was significantly lower (p=0.0085) in females with PCOS (8.14%) than in fertile females (21.00%). MTHFR 677 TT genotype had a decreased risk (3.7-fold) of PCOS compared with wild type (MTHFR 677 CC). CONCLUSION: Our data support a role for MTHFR mutant homozygous (677 TT) genotype in reducing risk in Korean infertile females with Polycystic ovarian syndrome.
Female* ; Genotype ; Humans ; Korea* ; Oxidoreductases* ; Polycystic Ovary Syndrome* ; Polymerase Chain Reaction ; Prevalence

Actinomycosis is a chronic suppurative and granulomatous disease. Actinomyces is a gram positive, anaerobic and non-acid fast bacterium. Many actinomycotic pelvic infection in women used intrauterine device(IUD) with long duration were reported, in contrast, others suggest that actinomycosis develop opportunistic infection irrespective of intrauterine device. One to ten percents of patients with acute pelvic inflammatory disease(PID) develop perihepatic inflammation and adhesion---the Fitz-Hugh-Curtis syndrome. Although in the past Neisseria gonorrhea was thought to be the only etiological agent, recent data indicate that chlamydia trachomatis produces the majority of cases. We have experienced the case of tubo-ovarian actinomycosis(case with IUD(Cu-T)) associated with Fitz-Hugh-Curtis syndrome in a 29years old woman, and reported that with a review of related literatures.
Actinomyces ; Actinomycosis* ; Chlamydia trachomatis ; Female ; Gonorrhea ; Humans ; Inflammation ; Intrauterine Devices ; Neisseria ; Opportunistic Infections ; Pelvic Infection

PURPOSE: p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance of p16 alterations is still controversial in ALL and has been reported to be either unfavorable or similar to that of other patients. We studied the correlation between loss of p16 protein confirmed by immunohistochemical staining and clinical outcomes of patients diagnosed as ALL. METHODS: We performed an immunohistochemical staining for p16 protein in 74 cases of bone marrow biopsy slide initially diagnosed as ALL between January 1998 and December 2006. We reviewed the clinical manifestations, laboratory findings, treatment outcomes retrospectively. RESULTS: Of 74 slides, 12 were negative for p16 protein. Seven were males and 5 were females with a median age at diagnosis was 5.8 (1.3-18.8) years. Initial WBC were 17,225 (500-403,300)/microL. By immunologic surface marker analysis, 7 patients were early pre-B CALLA (+) and 5 patients were T-cell ALL. Two patients of intermediate risk group had relapsed and died. Three patients had family history of breast cancer. Four patients died and overall survival rates were 53.5+/-18.7%. CONCLUSION: Loss of p16 protein is supposed to be an independent risk factor of childhood ALL associated with poor outcomes. In clinical setting, the clinician must take into account p16 status, not only at the genomic but also at the protein level. Further clinical experience on thoroughly investigated cases will help a better understanding between p16 status and clinical outcomes.
Biopsy ; Bone Marrow ; Breast Neoplasms ; Female ; Genes, p16 ; Genes, Tumor Suppressor ; Humans ; Leukemia ; Male ; Phosphorylation ; Phosphotransferases ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Risk Factors ; Survival Rate ; T-Lymphocytes