Inflammatory linear verrueous epidermal nevus (ILVEN) first mentioned by Unna in 1896 is a rare variant of epidermal nevus characterized clinically by early onset in childhood, moderate to marked pruritus and persistent clinical course and histopathologically by predominant features of a chronic dermatitis or psoriasis. We present tbe first recorded case of a typical ILVEN developed in a 20-year-old Korean male, who has had an intensely pruritic linear verrucous patch, involving the entire length of the posterior aspeet of right upper extremity, volar aspect of right thumb and nails of ind.ex and ring finger since 5 years. Microscopic examination of the skin, biopsy specimens from the lesion on the right elbow joint area and the palm showed hyperkeratosis witb focal parakeratosis, moderate to marked acanthosis and elongation of rete ridges and papilla with mild exocytosis and moderate perivascular lymphocytic infiltration. Literature were reviewed.
Biopsy ; Dermatitis ; Elbow Joint ; Exocytosis ; Fingers ; Humans ; Male ; Nevus ; Parakeratosis ; Pruritus ; Psoriasis ; Skin ; Thumb ; Upper Extremity ; Young Adult

No abstract available.

No abstract available.
Antibodies*

Subepiderral calcified nodules is a special form of idiopathic calcinosis circumscripta with its distinct clinical and histopathologic features, which was originally described by Winer(1952) as solitary congenital no3ular czlcification of the skin. Although the lesions are usually solitary and congenital, subs aquent investigators reported multiple lesions and later onset. Clinically, th. leions are small hard. yellowish-white warty nodules developed. usually on the face and mostly in children and histopathologically are subepidermal calcified mass with s cvn4ry epidermal changes. Although the pathogenesis is still unexplained, it s seems that the disease is not associated with any systemic or cutaneous disease or any biochemial abnormalities. We present a first recorded case of subepidermal calcified no3ules developed on the left the a Korasn female, aged 23, which has been present for 7 years. Shave biopsy showed typical histopathologic and histochemical features of the subpidermal calcified nodules. Literature were reviewed.
Biopsy ; Calcinosis ; Child ; Female ; Humans ; Research Personnel ; Skin

This study was done to investigate some selected epidemiological characteristics of accidents occured in the closed-ward of a psychiatric hospital in Seoul during one year period from Jan. 1, 1993 toDec. 31, 1993. For this study, 1,570 accidents(702 patients) reported from 1,833 discharged patients were analysed. Major findings obtained from this study were as follows; 1. Prevalence rate of the accidents were 38 persons per 100 discharged pateints and 86 accident spells per 100 discharged patients. 2. The highest risk of accident was noticed in the group of male, 20-29 age, middle school graduate, and divorced. 3. By diagnostic category, accident rates per 100 discharged patients were 339 spells in seizure disor-der, 102 in substance abuse, 93 in schizophrenia, 69 in alcoholism, and 61 in mood disorder. 4. By the period, the accident rate was higher within I month after admission, and the rate was higher in April and November, Wednesday, the day of family visiting, and during day time. 5. Accident types were violent behavior(53%), alcohol drinking(12%), emergency for physical episode(9%), elopement(7%), property damage (5%), self-inflicted injury and suicidal attempt (4%). Severity of damage was usually minimal, and the persons who were commonly involved in the accidents were the petients rather than him self and therapist.
Alcoholism ; Divorce ; Emergencies ; Epidemiologic Studies* ; Hospitals, Psychiatric* ; Humans ; Male ; Mood Disorders ; Prevalence ; Schizophrenia ; Seizures ; Seoul ; Substance-Related Disorders

No abstract available.
Humans ; Nitroblue Tetrazolium* ; Skin* ; Tuberculosis, Cutaneous*

There have been reported some important findings in immunology of psoriasis, such as lower than normal level of IgM, defective humoral immune, responsiveness to newly administered antigens during cytotoxic drug therapy, lower than normal incidence of active sensitization with DNCB, prolonged skin heterograft survival and presence of anti-IgG antibody in peripheral lymphocytes. These findings are strongly suggestive of some humoral as well as cellular immunne dysfunction in patients with psoriasis. The present study was undertaken to evaluate the therapeutic effectiveness of BCG, a potent nonspecific immune stimulator, in patierts with psoriasis. Total 41 cases of more than 2 years' duration of illness and with widespread involvement and having had history of various previous treatment were slelcted at the Department of Dermatology, National Medical Center during October, 1973 and October, 1974, Liquid BCG(manufactured by NIH, Korea) was administered intradermally in a starting dose of 0.1 ml(0.01 mg in dry weight) weekly. The dosage of BCG was increased to 0.3 or 0.5ml after 3 or 5 injections and this dosage was maintained until some clinical changes were observed. The mean injection time to each patient was 20. 7.The results were as follows: 1. Eighteen cases showed no therapeutic response or aggravation of the lesions. 2. Six cases showed good therapeutic effect, resulting in only a few small lesions remained on elbows, knees or scalp areas. 3. Fourteen cases showed excellent therapeutic effect, that is complete disappearance of the lesions. During 2 to 6 months'follow up period, 7 cases showed relapse and the remainders are still under observation. The mechanism of influence of BCG on the clinical course of psoriatic patients is not determined, however, possible mechanism was discussed.
Allergy and Immunology ; Dermatology ; Dinitrochlorobenzene ; Drug Therapy ; Elbow ; Heterografts ; Humans ; Immunoglobulin M ; Incidence ; Knee ; Lymphocytes ; Mycobacterium bovis* ; Psoriasis* ; Recurrence ; Scalp ; Skin

Irritant or allergic contact dermatitis presents usually eczematous process or occasionally noneczematous lesions like in this case. We report a case of erythema rnultiforme-like eruptions in a 40-year-old female who presented multiple iris or annular shaped maculopapular eruptions on both hands and forearms after contact of lacquer tree. Being performed with standard patch test screening series, lacquer tree extracts and urushiol, she showed significant reactions to the lacquer tree and urushiol. Histopathologic findings showed both features of erythema multiforme and suh acute contact dermatitis.
Adult ; Dermatitis, Allergic Contact ; Dermatitis, Contact ; Erythema Multiforme* ; Erythema* ; Female ; Forearm ; Hand ; Humans ; Iris ; Lacquer* ; Mass Screening ; Patch Tests ; Trees*

Accidental vaccinia may occur either in a recently vaccinated person through autoinoculation by veticular fluid or in a person who is in close personal contact with a recently vaccinated person. Accidental vaccinia occurs most co@mmonly on the eyelid, lips, nose or vulva. An outbreak of similar lesions in a family is unusual. We presented a case of accidental vaccinia in a 29-year old married woman. She has been relatively well until 5 days prior to visit, when she began developed painful grouped papules with central umbilication around both mammary areolas and nipples and marked painful swelling of both axillary lymphnodes. Family history revealed that her baby has also suffered from vesicopustuIar eruptions on upper lip 10 days before her onset and her nephew had similar skin eruption on left index finger for the last 1 week. Contact tracing revealed her neighboring child who was smallpox vaccinated inoculated her baby and then she was contracted from her baby, so-called, third hand vaccinia. Physical examination was not remarkable and laboratory findings were within normal limit. The biopsy finding showed findings consistent with viral infection. After symptomatic treatment and daily dressing, the akin lesion has completly healed in about 2 weeks.
Adult ; Bandages ; Biopsy ; Child ; Contact Tracing ; Eyelids ; Female ; Fingers ; Hand ; Humans ; Lip ; Nipples ; Nose ; Physical Examination ; Skin ; Smallpox ; Vaccinia* ; Vulva

Several investigators have attempted to clarify th well-known phenomenon of anergy in lepromatous leprosy during past two decades, utilizing various methods of immunologic assessrvent, including response to skin test antigens, active skin sensitization with strong allergens, skin homograft survival rate, imrnunopathology of lymphnodes, in vitro blastogenic response by antigens or mitogens of lymphocytes, lymphokine production in vitro and measurement of peripheral T and B cell ratio. Howcver, there is no general agreement as to the cellular irnmunologic status of leprosy patients b tween various investigators. The present study was undertaken to evaluate the ability to mount cutaneous hypersensitivity reactions to various skin test antigens and to investigate active sensitization with DViCB in patients with leprosy. Ten polar lepromatous (LL) and 12 polar tuberculoid (TT) p-tients who have been treated at Department of Dermatology, National Iviedical Center and Seoul Nationa,l University Hospital were the subjects. The subjects have rcceived regular antileprosy chemotherapy with DDS and the average duration of treatment in LL and TT groups was 6. 2 and 4. 7 years, respectively. The control group included 10 healthy physicians and nurs-s. Skin test antigens includ=d lepromin (1 x10' bacilli,ml'), PPD (Parke-Davis 5ppJ/0.1ml), SK-SD (Lederle, 40 u SK and 10 u SD/0.1 ml), Candidin (Hollister stier Lab 1: 1000 dilution) and DNCB aceton solution in the concentrations of 1000ug,/0.1ml for sensitization and 100ug/0.1ml for challenge, respcctively. Skin reactions were read 48 hours after intraderrnal injection of 0.1 rnl of each antigen anci th.' metho4 of DNCB sensitization was same as described elsewhere. The result showed that in polar lepromatous leprosy patients, the skin reactivity to various antigens were generally decroased, as cornpared to both th healthy control group and polar tuberculoicl patients, especially to lepromin, PPD and I')NCB sensitization (p<0.05, respectively). We concluded thxt lepromatous leprosy patients were especially unresponsive to mycobacterial antigcns(lepromin and PPD) and to newly administered antigen (DNCB) and tbe possible mechanism was discussed.
Allergens ; Allografts ; Antigens ; Dermatology ; Dinitrochlorobenzene ; Drug Therapy ; Humans ; Hypersensitivity* ; Lepromin ; Leprosy* ; Leprosy, Lepromatous ; Lymphocytes ; Mitogens ; Research Personnel ; Seoul ; Skin Tests* ; Skin* ; Survival Rate