Three groups of patients with newely diagnosed hypertension, or with hypertension not optimally controlled by previous treatment, completed a comparative study on the effects of Dihydrochlorothiazide, propranolol, and prazosin on plasma lipids after three months therapy. The drugs showed equipotent antihypertensive effects(P<0.01). Dihydrochlorothiazide administration was associated with a significant elevation of total cholesterol(42%, P<0.05), and triglyceride(8.1%, P<0.01). Changes of HDL-C(5.1%), LDL-C(3.3%), and cholesterol ratio(-4.8%) were not significant. Propranolol administration was associated with significant elevation of total cholesterol(3.8%, P<0.05), triglyceride(14.5%, P<0.005), and LDL-C(5.6%, P<0.005). Reduction of HDL-C(-7.8%, P<0.05) and cholesterol ratio(-14.7%, p<0.005) was also statistically significant. Prazosin administration was associated with significant decrease in total cholesterol(-6.6%, P<0.005), triglycride(-9.6%, P<0.005), and LDL-C(-11.7%, P<0.005), and significant elevation of HDL-C(10.6%,P<0.005) and cholesterol ratio(24.2%, P<0.005) was noted.
Cholesterol ; Humans ; Hydrochlorothiazide* ; Hypertension* ; Plasma ; Prazosin* ; Propranolol*

PURPOSE: To evaluate the results of primary cementless total hip arthroplasty (THA)using the Landos Atoll hydroxyapatite (HA)-coated cup and the Euroform HA-coated stem. MATERIALS AND METHODS: Sixty-four primary THA were performed between November 1991 and October 1994, and were followed more than 5 years. Clinical and radiological results were assessed.Also, the evidence of loosening were observed. RESULTS: The mean Harris hip score improved from 57.0 points preoperatively to 88.5 points postoperatively. Of the 64 cases of emoral stems, 54 cases (84.4%) were classified as stable bone-ingrowth ixa tion, and 10 cases (15.6%)as stable fibrous fixation at the last follow-up. The linear wear of polyethylene insert was 1.83 mm (0.14-4.15 mm)and the linear wear rate was 0.23 mm/yr (0.02-0.72 mm/yr).During the follow-up period, revisions were required in 31 cases (48.4%);18 cases (28.1%)had been reoperated upon and 13 cases were (20.3%)awaiting for reoperation. Excessive early osteolysis were observed in 3 cases within 5 year.1 case in those 3 cases underwent cup revision and another 2 cases underwent head and liner change with bone grafting. CONCLUSION: Landos Atoll HA-coated acetabular cup which followed for minimum 5 years reveals 48.4% failure rate.
Acetabulum ; Arthroplasty, Replacement, Hip ; Bone Transplantation ; Durapatite ; Follow-Up Studies* ; Head ; Hip ; Osteolysis ; Polyethylene ; Prostheses and Implants* ; Reoperation