The skin is a frequently involved organ in graft-versus-host disease(GVHD). Various skin lesions including erythematous eruption, bullae, desquamation, lichenoid, and sclerodermoid lesions have been reported in GVHD, but vitiligo-like lesions were. We present two cases of chronic GVHD presenting multiple hypopigmented patches following allogenic bone marrow transplant(BMT) due to severe aplastic anemia. The histopathologic studies showed focal vacuolar degeneration of basal cells, absence of melanocytes in the epidermis, and perivascular lymphocytic infiltration consisting of T cells in the upper dermis, These cases suggest that vitiligo-like lesions may develop due to marked melanocyte- lymphocyte interaction after BMT.
Anemia, Aplastic ; Bone Marrow ; Dermis ; Epidermis ; Lymphocytes ; Melanocytes ; Skin* ; T-Lymphocytes ; Vitiligo

Serratia marcescens is a gram-negative bacillus of enterobacteriaceae family. The organism is known to cause various types of infection including cellulitis, bacteremia, pneumonia, endocarditis, meningitis, peritonitis, osteomyelitis, and septic arthritis. Cellulitis due to gram-negative organisms is uncommon and usually occurs in immunosuppressed hosts. We present a case of S. marcescens cellulitis in a patient with acute lymphocytic leukemia who had been treated with chemotherapy. Microbial studies with pus identified S. marcescens as a causative organism of cellulitis. The lesion healed completely by antibiotic treatment.
Arthritis, Infectious ; Bacillus ; Bacteremia ; Cellulitis* ; Drug Therapy ; Endocarditis ; Enterobacteriaceae ; Humans ; Immunocompromised Host ; Leukemia ; Meningitis ; Osteomyelitis ; Peritonitis ; Pneumonia ; Precursor Cell Lymphoblastic Leukemia-Lymphoma* ; Serratia marcescens* ; Serratia* ; Suppuration

The Laugier-Hunziker syndrome represents a rare, acquired, benign, pigmentary disorder of the lips, oral mucosa, and nails. The nails are often involved with the development of melanonychia, which may be due to focal melanocyte activation. The lips and the mucous membranes show a variable number of flat, gray to brown-black lenticular spots, which are usually asymptomatic. We report the third case of Laugier-Hunziker syndrome in the Korean literatures.
Lip ; Melanocytes ; Mouth Mucosa ; Mucous Membrane

BACKGROUND: Ultraviolet irradiation causes various changes in cells or tissues including DNA damage, which results in changes of cell cycling, mutation and cell death such as apoptosis or necrosis. p53 has been studied widely to be as a regulator gene to modulate cell cycling. Previous report shows that RAD50 is a gene to be associated with p53 to repair damaged DNA. OBJECTIVE AND METHOD: In this study, we evaluated changes of RAD50 and p53 expression by ultraviolet B (UVB) irradiation in rat skin in vivo and in human fibroblasts (hF) in vitro. RESULTS: In rat skin irradiated with 400mJ/cm2 UVB, RAD50 protein and mRNA expression were decreased by from early stage after irradiation, and they were restored to its normal level after 12 h. In hF irradiated with 20mJ/cm2 UVB, change of RAD50 expression by UVB irradiation was similar to that of rat skin. On the contrary, p53 protein expression was increased by UVB irradiation from 6 h and 3 h after UVB irradiation in rat skin and hF, respectively, but p53 mRNA expression was not changed by UVB irradiation. CONCLUSION: RAD50 and p53 expression is modulated differently in UVB- irradiated skin. Further studies are warrented to evaluate functional relationship between the genes in repairing damaged DNA.
Animals ; Apoptosis ; Cell Death ; DNA ; DNA Damage ; Fibroblasts ; Genes, Regulator ; Genes, vif ; Humans ; Necrosis ; Rats ; RNA, Messenger ; Skin*

No abstract available.
Anesthesia* ; Anesthesia, General* ; Humans

Retroperitoneal duodenal rupture is rare and is often difficult to diagnose on the plain abdominal x-ray. From a review of the plain abdomen films of 21 cases with retroperitoneal duodenal rupture, confirmed by operation, pneumoretroperitoneum was revealed in 16 cases; Air in the peritoneum was manifested as a bubbly shadow in 12 cases, a renal halo in 9 cases, air shadow along the right psoas margin in 2 cases, air along the diaphragmatic crus in 2 cases and air in the right properitoneal fat in 2 cases, US and CT also revealed air bubbles and fluid collection around the right kidney. We recommend the plain abdomen as a useful diagnostic method for detection of pneumoretroperitoneum.
Abdomen* ; Kidney ; Methods ; Peritoneum ; Retropneumoperitoneum ; Rupture*

No abstract available.
Phonation*

BACKGROUND: In recent times, it has been gradually emphasized that an aspect of diseases impacting on the quality of an individuals life goes beyond physical impairments with the development of economic and medical technology. Skin diseases especially may be associated with a variety of negative psychologic effects, such as low self-esteem, feelings of inferiority because skin lesions are exposed to others and cause cosmetic problems. Many researchers have been already established various dermatology-specific questionnaires and disease-specific questionnaires in developed countries, but these are rare in Korea. OBJECTIVE: We tried to survey the social, psychological and physical aspects of patients with vitiligo and psoriasis to evaluate the impact of skin diseases on the quality of life in Korea. METHODS: We inquired after 64 patients by using a dermatology-specific questionnaires Skindex recently developed by Chren et al. It has 6I-items and eight scales including cognitive, social, depression, fear, embarrassment, anger, physieal discomfort, and physical limitatians.
Anger ; Depression ; Developed Countries ; Humans ; Korea ; Psoriasis* ; Quality of Life* ; Skin Diseases* ; Skin* ; Vitiligo* ; Weights and Measures ; Surveys and Questionnaires

Anomalous origin of a coronary aortic artery is a rare cardiac anomaly. Although it can cause angina, syncope, and palpitations, most patients are asymptomatic. This anomaly requires surgical treatment or intervention because it is associated with sudden death. Several surgical techniques, such as coronary reimplantation, coronary artery bypass grafting (CABG), unroofing, and neo-ostium formation, have been proposed as treatments. We report a case surgically treated with neo-ostium formation in anomalous origin of the left coronary artery from the right coronary sinus.
Arteries ; Coronary Artery Bypass ; Coronary Sinus ; Coronary Vessels ; Death, Sudden ; Humans ; Replantation ; Syncope

No abstract available.
Aged ; Colitis, Ischemic/complications/*diagnosis/therapy ; Cystitis/*diagnosis/etiology ; Dehydration/etiology ; Diarrhea/etiology ; Female ; Fluid Therapy ; Humans ; Hydronephrosis/*diagnosis/etiology ; Oliguria/etiology ; Predictive Value of Tests ; Radiation Injuries/*diagnosis/etiology ; Tomography, X-Ray Computed