1.Effect of Some Immunosuppressive Agents on the Survival of Experimental Skin Homografts in Rats I. Effect of Total Body Irradiation, Imuran, Prednisolone and Splenectomy.
Won Suk KIM ; Soo Duk LIM ; Hong Sik KIM
Korean Journal of Dermatology 1970;8(1):3-9
Several immunosuppressive agents were used to prolong the survival of full-thickries skin homografts in albino rats. The grafts were squares in size of 2.0cm. The results were as follows. 1. The mean survival time of skin homografts in control group was 6.0 days. 2. Total body X-irradiation (500r) to the recipients 24 hours before grafting resulted in prolongation of survival of the grafts. (Mean, 12.5 days) 3. Administration of Imuran(azathioprine) to the recipients in a does of 5mg/kg/day for 7 days. before grafting resulted in prolongation of survival of the grafts. (Mean, 9. 6 days) 4. Spleneetomized homografted rats showed no prolongation of survival of the grafts. (Mean, 6.1days) 5. Administration of prednisolone to the recipients in a does of 2mg/kg/day for 7 days before grafting resulted in no prolongation of survival of the grafts. (Mean, 6.3 days) 6. Above results were discussed and compared with those of others.
Allografts*
;
Animals
;
Azathioprine*
;
Immunosuppressive Agents*
;
Prednisolone*
;
Rats*
;
Skin*
;
Splenectomy*
;
Survival Rate
;
Transplants
;
Whole-Body Irradiation*
2.The clinical survey of gastric cancer in young adults.
Won Sik LIM ; Young Dong MIN ; Hyun Jin CHO
Journal of the Korean Surgical Society 1991;41(1):22-28
No abstract available.
Humans
;
Stomach Neoplasms*
;
Young Adult*
3.Drug - Induced Esophageal Ulcers.
Han Lim MOON ; In Sik CHUNG ; Sang Hong BAEK ; Kyu Sik SHIM ; Chang Don LEE ; Suk Won HAN ; Kyu Won CHUNG ; Hee Sik SUN ; Whan Kook CHUNG
Korean Journal of Gastrointestinal Endoscopy 1985;5(1):11-15
Over 26 kinds of tablets and capsules, such as Tetracycline, Quinidine and Potassium preparations were reported to cause esopbageal ulcerations, eharacterized in various size, shape and number, ind sually in mid-esophagus, Recently authors experienced 10 cases of drug-induced esophageal ulcerations due to antibiotics and antiinflammatory agents such as Tetracycline, Aspirin, etc. Four cases were men and six were women. Four cases were in third dades, three in fourth cleeades, two in fifth decades and one in sixth decades. Presenting symptoras were odynophagia(4/10), dysphagia(3/10), substernal pain(7/10) and epigastric pain(3/10). Endoscopic examination of the esophgus showed single or multiple, small and shallow ulcers on the mid-esophgeal mucosa at the level of 30cm from the ineisor in eight cases, one Iarge and deep ulcer at the level of 40cm from incisor in one patient and one amall, shallow and one large, deep ulcers at the same time. in one patient The shape of alcers were various from a round to a large horseshoe shaped one. The clinical course was mild without complications. It was suggested that drug-induced esophsgeal ulcers with antibiotics and antiinflammatory agents could be found frequently and they had benign and mild clinicalc ourse,
Anti-Bacterial Agents
;
Anti-Inflammatory Agents
;
Aspirin
;
Capsules
;
Female
;
Humans
;
Incisor
;
Male
;
Mucous Membrane
;
Potassium
;
Quinidine
;
Tablets
;
Tetracycline
;
Ulcer*
4.A Study on the Serologic Parameters in Petients with Anemia of Chronic Renal Failure-According to Erythropoietin Treatment.
Jong Sik LIM ; Ho Jung KANG ; Won Jong PARK ; Jun Young DO ; Kyeung Woo YUN
Yeungnam University Journal of Medicine 1994;11(1):82-93
Clinical study was carried out on the 64 hemodialysis patients(HD) with chronic renal failure who had been treated from December 1992 to July 1993 in Yeungnam University Hospital. The following results were obitained. In hematologic parameters, MCH was 28.8±2.0pg, and MCV was 92.4±4.7fl. Result revealed normochromic and normocytic anemia. Mean values of serum ferritin were 657.4±292.0ng/ml in men and 511.5±370g in women. Mean values of serum iron were 145.5±63.7µg/dl. Mean values of transferrin saturation was 61.6±28.4%. Serum frerritin, serum iron and transferrin saturation were higher in HD group than normal reference. In erythropoeitin treatment group, Hb and Hct were significantly higher than non-erythropoietin treatment group. Amount of transfusion was significantly higher in non-erythropoietin treatment group than erythropoeitin treatment group(p<0.05). Values of iron, transferrin saturation were significantly higher in abnormal liver function test(LFT0 hemodialysis group than normal LFT group(p<0.05). Transfusion amounts revealed positive correlation with ferritin(r=0.4675), transferrin satruation (r=0.3823) and iron(r=0.3386) (p<0.05).
Anemia*
;
Clinical Study
;
Erythropoietin*
;
Female
;
Ferritins
;
Humans
;
Iron
;
Kidney Failure, Chronic
;
Liver
;
Male
;
Renal Dialysis
;
Transferrin
5.A case of bronchial arterial embolization of massive hemoptysis.
Youn Sik LIM ; Jung Eun SUH ; Suk JEONG ; Dong Ill CHO ; Jae Won KIM
Tuberculosis and Respiratory Diseases 1991;38(4):396-400
No abstract available.
Hemoptysis*
6.The Central Island Occurrence Rate and Correlation between the Central Island and Corrected Visual Acuity after Excimer Photorefractive Keratectomy According to the Myopia Degree.
Byoung Kak LIM ; Young Sik KIM ; Hung Won TCHAH
Journal of the Korean Ophthalmological Society 1997;38(8):1388-1392
We examined 60 eyes of 60 patients after excimer photorefractive keratectomy(PRK) for myopia and analyzed the changes of central island on corneal topography for 6 months prospectively. These patients were divided into two groups according to the degree of myopia, group 1(26 eyes, 6 diopters or below by spherical equivalent) and group 2 (34 eyes, over 6 diopters). The occurrence rate of central island was 76.4% collectively, 87.5% in group 1, 67.7% in group 2 at 2 weeks after PRK. It decreased to 30.4%, 43.5%, and 21.1% respectively at 6 months after PRK and was lower in group 2 than group 1. However there was no statistically significant correlation between the reduction of central island size and improvement of corrected visual acuity in both groups. In conclusion, the central island disappeared and decreased the amount for six months follow-up period after PRK and seems to be no effect on the corrected visual acuity.
Corneal Topography
;
Follow-Up Studies
;
Humans
;
Myopia*
;
Photorefractive Keratectomy*
;
Prospective Studies
;
Visual Acuity*
7.CT Evaluation of Solitary Pulmonary Nodule.
Won Dong KIM ; Koun Sik SONG ; Young Hwan KIM ; Tae Hwan LIM ; Ki Young KO
Journal of the Korean Radiological Society 1995;32(1):85-91
PURPOSE: To evaluate criteria for differentiating benign versus malignant solitary pulmonary nodules (SPNs) by analyzing their morphology and perinodular parenchymal changes on CT/HRCT. MATERIALS AND METHODS: We retrospectively reviewed the CT/HRCT in 99 patients with SPN. Sixty two cases were proved by surgery, PCNA, clinical follow up and etc. Thirty seven cases were diagnosed by typical benign calcification. We defined SPN as a discrete, single lesion in the lung with margins that are sharp enough to permit measurement of diameter. We excluded lesions more than 4cm in diameter and lesions with cavity from our study protocol. The study included 41 malignant nodules and 58 benign nodules. RESULTS: Mean diameter of malignant nodule was 2.9cm, benign nodule was 2.2cm. Peripheral location of nodule was 28 in malignant nodules, 50 in benign nodules. Typical benign calcification was observed in 37 tuberculoma and three hamartoma. Lobulated margin was noted in 32 malignant nodules and 14 benign nodules. Spiculated margin was observed in 17 malignant nodules and 20 benign nodules. Low attenuation within the nodule was observed in 14 malignant nodules and 12 benign nodules. Pleural tail was observed in 14 malignant nodules and 31 benign nodules. Air bronchogram was noted in 18 malignant nodules and 4 benign nodules. Juxta nodular tuberculosis was observed in 6 malignant nodules and 29 benign nodules. CONCLUSION: Malignant nodules were larger than benign nodules and more commonly demonstrated a Iobulated contour and air bronchogram (p<0.05). Benign nodules more commonly demonstrated low density in the nodule and associated with juxta nodular tuberculosis and peripheral location (p<0.05). Spiculated margin and pleural tail were not helpful to differentiate benign from malignant nodule.
Follow-Up Studies
;
Hamartoma
;
Humans
;
Lung
;
Proliferating Cell Nuclear Antigen
;
Retrospective Studies
;
Solitary Pulmonary Nodule*
;
Tuberculoma
;
Tuberculosis
8.CT Evaluation of Solitary Pulmonary Nodule.
Won Dong KIM ; Koun Sik SONG ; Young Hwan KIM ; Tae Hwan LIM ; Ki Young KO
Journal of the Korean Radiological Society 1995;32(1):85-91
PURPOSE: To evaluate criteria for differentiating benign versus malignant solitary pulmonary nodules (SPNs) by analyzing their morphology and perinodular parenchymal changes on CT/HRCT. MATERIALS AND METHODS: We retrospectively reviewed the CT/HRCT in 99 patients with SPN. Sixty two cases were proved by surgery, PCNA, clinical follow up and etc. Thirty seven cases were diagnosed by typical benign calcification. We defined SPN as a discrete, single lesion in the lung with margins that are sharp enough to permit measurement of diameter. We excluded lesions more than 4cm in diameter and lesions with cavity from our study protocol. The study included 41 malignant nodules and 58 benign nodules. RESULTS: Mean diameter of malignant nodule was 2.9cm, benign nodule was 2.2cm. Peripheral location of nodule was 28 in malignant nodules, 50 in benign nodules. Typical benign calcification was observed in 37 tuberculoma and three hamartoma. Lobulated margin was noted in 32 malignant nodules and 14 benign nodules. Spiculated margin was observed in 17 malignant nodules and 20 benign nodules. Low attenuation within the nodule was observed in 14 malignant nodules and 12 benign nodules. Pleural tail was observed in 14 malignant nodules and 31 benign nodules. Air bronchogram was noted in 18 malignant nodules and 4 benign nodules. Juxta nodular tuberculosis was observed in 6 malignant nodules and 29 benign nodules. CONCLUSION: Malignant nodules were larger than benign nodules and more commonly demonstrated a Iobulated contour and air bronchogram (p<0.05). Benign nodules more commonly demonstrated low density in the nodule and associated with juxta nodular tuberculosis and peripheral location (p<0.05). Spiculated margin and pleural tail were not helpful to differentiate benign from malignant nodule.
Follow-Up Studies
;
Hamartoma
;
Humans
;
Lung
;
Proliferating Cell Nuclear Antigen
;
Retrospective Studies
;
Solitary Pulmonary Nodule*
;
Tuberculoma
;
Tuberculosis
9.Familial Sarcoidosis, The First Report in Korea.
Wan Sik UHM ; Chae Man LIM ; Woo Sung KIM ; Dong Soon KIM ; Won Dong KIM
Tuberculosis and Respiratory Diseases 1994;41(6):644-650
Sarcoidosis can affect two or more members of the same family, and the reported occurrence of such familial sarcoidosis is variable from 0.5 to 14%. Recently we have experienced familial sarcoidosis affected mother and daughter, for the first time in Korea. Mother was diagnosed as Stage II sarcoidosis 4 years ago by transbronchial lung biopsy and cervical lymph node biopsy with compatible BAL finding in our hospital. This time, the daughter was admitted with bilateral hilar enlargement and anterior uveitis. Even though she had positive tuberculin skin test and atypical BAL finding(lymphocyte: 61%, CD4/CD8: 1.22). Transbronchial lung biopsy and mediastinal lymph node biopsy revealed noncaseating epithelioid granulorna without AFB. Slit lamp examination of the eyes showed severe anterior uveitis. Systemic steroid therapy was started due to progressive uveitis with antituberculous medication.
Biopsy
;
Humans
;
Korea*
;
Lung
;
Lymph Nodes
;
Mothers
;
Nuclear Family
;
Sarcoidosis*
;
Skin Tests
;
Tuberculin
;
Uveitis
;
Uveitis, Anterior
10.CT Findings of Solitary Tuberculoma with a Cavity.
Koun Sik SONG ; Tae Hwan LIM ; Dong Erk GOO ; Hyun Woo GOO ; Won Dong KIRN
Journal of the Korean Radiological Society 1994;31(3):477-482
PURPOSE: Differential diagnosis of solitary pulmonary nodule with cavity includes lung abscess, tuberculoma, bronchogenic carcinoma, metastasis and trauma, etc. We analyzed the CT appearance of tubercuioma presenting as a solitary pulmonary nodule with cavity and describe the findings which suggest tuberculoma in the differential dignosis of soliary pulmonary nodule with cavity. MATERIALS AND METHODS: 25 patients with solitary pulmonary nodule(diameter less than 4 cm) without surrounding parenchymal consolidation on chest radiograph, who had a cavity within the nodule on CT, were included in our study. Density of the nodule, maximal wall thickness, the character of inner and outer wall margin, location of cavity within the nodule, location of the nodule, presence or absence of satellite lesions and calcification were analyzed. RESULTS: Solitary tuberculoma with cavity showed maximal wall thickness more than 15 mm in 40%(10/25) and 5-14 mm in 56%(14/25), eccentric cavitation in 84%(21/25) and concentric cavitation in 16%(4/25), spiculated outer wall margin in 56%(14/15) and Iobulated margin in 32%(8/25), smooth inner wall margin in 60%(15/25) and nodular margin in 40%(10/25). CT density of the cavity wall compared with the chest wall muscle was low in 84%(21/25) and isodense in 16%(4/25). Accompanying satellite lesions were seen in 84% (21/25) and calcification was visible in 28%(7/25). CONCLUSION: The CT findings of solitary tuberculoma with cavity are relative peripheral location, eccentric cavitation, finely spiculated outer wall margin, and mean maximal wall thickness of 13.2 mm, which are also the common features of malignant nodule. However, relative low density of the nodule compared to the chest wall muscle and surrounding satellite lesions can be additional clues favoring solitary tuberculoma with cavity on CT.
Carcinoma, Bronchogenic
;
Diagnosis, Differential
;
Humans
;
Lung Abscess
;
Neoplasm Metastasis
;
Radiography, Thoracic
;
Solitary Pulmonary Nodule
;
Thoracic Wall
;
Tuberculoma*