1.MRI and histologic findings of papillary craniopharyngioma.
Tae Wook KANG ; Myung Shik LEE ; Kwang Won KIM ; Yeon Lim SUH
Korean Journal of Medicine 1999;57(2):235-237
No abstract available.
Craniopharyngioma*
;
Magnetic Resonance Imaging*
2.Analysis of clinical contents of new patients in a local family practice clinic.
Cheol Dong OH ; Mee Lim KIM ; Jin Sook WON ; Haeng Hoon LEE ; Eui Shik CHUNG
Journal of the Korean Academy of Family Medicine 1993;14(2):72-78
No abstract available.
Family Practice*
;
Humans
3.A clinical analysis of unresectable bile duct cancer.
Won Shik LIM ; Young Don MIN ; Hyun Jin CHO ; Hong Joon CHEON
Journal of the Korean Surgical Society 1991;41(1):47-54
No abstract available.
Bile Duct Neoplasms*
;
Bile Ducts*
;
Bile*
4.A Case of Berardinelli Lipodystrophy Syndrome.
Jin Soon HWANG ; Jung Sub LIM ; Se Young KIM ; Kye Shik SHIM ; Sei Won YANG ; Jee Suk YU
Journal of Korean Society of Pediatric Endocrinology 1997;2(2):274-276
Berardinelli lipodystrophy syndrome is a rare autosomal recessive disorder, characterized by loss of body fat, muscular hypertrophy, acanthosis nigricans, hepatomegaly, hyperlipidemia, insulin resistant diabetes, and elevated metabolic rate. The mechanism(s) responsible for these abnormalities is not known. We report a forteen-month old girl with Berardinelli Lipodystriphy Syndrome, who had signs above mentioned, with a brief review and its related literatures.
Acanthosis Nigricans
;
Adipose Tissue
;
Female
;
Hepatomegaly
;
Humans
;
Hyperlipidemias
;
Hypertrophy
;
Insulin
;
Lipodystrophy*
5.The Effectiveness of Once-daily Intravenous Busulfan as a Conditioning Regime for Hematopoietic Stem Cell Transplantation in Children with Acute Myelogenous Leukemia.
Seong Shik PARK ; Jeong Won KWAK ; Young Tak LIM
Korean Journal of Hematology 2009;44(1):1-7
BACKGROUND: There have recently been some reports suggesting that once-daily intravenous busulfan (IV Bu) as a conditioning regime for hematopoietic stem cell transplantation (HSCT) possibly reduces the toxicities without influencing the clinical outcome as compared with the traditional 4 times daily dosage schedule. We report here on the clinical outcome of once-daily IV Bu as a conditioning regime for HSCT in children with AML at a single treatment center. METHODS: We retrospectively analyzed nine AML children who received HSCT with using the once-daily IV Bu (110~130 mg/m2 on 4 consecutive days) conditioning regimen at the Department of Pediatrics, Pusan National University Hospital from 2003 to 2007. RESULTS: The median age at HSCT was 8.25 years. As for the conditioning regimens, the HLA-matched sibling peripheral HSCT (N=4) was Flu/Bu, the CBT and unrelated BMT (N=4) was Flu/Bu/ATG and the autologous HSCT (N=1) was Bu/Cy. There was only one case of primary graft failure in an unrelated donor CBT recipient. The median time to neutrophil engraftment was 14 days and the median time to platelet engraftment was 19 days. The transplant-related toxicities were acceptable; there were no case with CNS toxicity and VOD was observed in two cases (1 mild case of VOD and 1 moderate case of VOD). Acute GVHD was noted in two cases (1 case of grade I and 1 case of IV). With a median follow up of 33 months, there were two cases of relapse and two cases of death. CONCLUSION: Once-daily IV Bu as a conditioning regimen for HSCT in children with AML was well tolerated and convenient with relatively moderate toxicities, but additional studies are needed to determine the therapeutic efficacy and pharmacokinetics of once-daily IV Bu in children who are undergoing HSCT.
Appointments and Schedules
;
Blood Platelets
;
Busulfan
;
Child
;
Follow-Up Studies
;
Hematopoietic Stem Cell Transplantation
;
Hematopoietic Stem Cells
;
Humans
;
Leukemia, Myeloid, Acute
;
Neutrophils
;
Pediatrics
;
Recurrence
;
Retrospective Studies
;
Siblings
;
Transplants
;
Unrelated Donors
6.New Korean reference for birth weight by gestational age and sex: data from the Korean Statistical Information Service (2008-2012).
Jung Sub LIM ; Se Won LIM ; Ju Hyun AHN ; Bong Sub SONG ; Kye Shik SHIM ; Il Tae HWANG
Annals of Pediatric Endocrinology & Metabolism 2014;19(3):146-153
PURPOSE: To construct new Korean reference curves for birth weight by sex and gestational age using contemporary Korean birth weight data and to compare them with the Lubchenco and the 2010 United States (US) intrauterine growth curves. METHODS: Data of 2,336,727 newborns by the Korean Statistical Information Service (2008-2012) were used. Smoothed percentile curves were created by the Lambda Mu Sigma method using subsample of singleton. The new Korean reference curves were compared with the Lubchenco and the 2010 US intrauterine growth curves. RESULTS: Reference of the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles birth weight by gestational age were made using 2,249,804 (male, 1,159,070) singleton newborns with gestational age 23-43 weeks. Separate birth weight curves were constructed for male and female. The Korean reference curves are similar to the 2010 US intrauterine growth curves. However, the cutoff values for small for gestational age (<10th percentile) of the new Korean curves differed from those of the Lubchenco curves for each gestational age. The Lubchenco curves underestimated the percentage of infants who were born small for gestational age. CONCLUSION: The new Korean reference curves for birth weight show a different pattern from the Lubchenco curves, which were made from white neonates more than 60 years ago. Further research on short-term and long-term health outcomes of small for gestational age babies based on the new Korean reference data is needed.
Asian Continental Ancestry Group
;
Birth Weight*
;
Female
;
Gestational Age*
;
Growth Charts
;
Humans
;
Infant
;
Infant, Newborn
;
Information Services*
;
Male
;
United States
7.The effect of Treponema denticola immunoinhibitory protein on cytokine expression in T cells.
Sang Yup LEE ; Won Jun SHON ; Woocheol LEE ; Seung Ho BAEK ; Kwang Shik BAE ; Sungsam LIM
Journal of Korean Academy of Conservative Dentistry 2004;29(5):479-484
Immunoinhibitory protein extracted from sonicated Treponema denticola have been shown to suppress cell cycle progression of human lymphocytes. To study in detail about the effect of this microorganism on the function of lymphocytes, we investigated the levels of Interleukin-2 (IL-2) and Interleukin-4 (IL-4) production by T lymphocytes before and after the addition of 12.5 microg/ml T. denticola sonicated extracts. In this study, levels of IL-2 and IL-4 produced from T cells pretreated with sonicated extracts were evaluated by using the quantitative sandwich enzyme immunoassay technique. In response to phytohemagglutinin (PHA) stimulation, T cell produced increased levels of IL-2 and IL-4. However, the expressions of both cytokines were significantly inhibited when PHA activated-T cells were pre-exposed to sonicated T. denticola extracts (p < 0.05). These findings suggest that the T. denticola sonicated extracts induced-immunosuppression in Th1 and Th2 cell functions could be a part of the pathogenic mechanism of the endodontic failure associated with this microorganism.
Cell Cycle
;
Cytokines
;
Humans
;
Immunoenzyme Techniques
;
Interleukin-2
;
Interleukin-4
;
Lymphocytes
;
T-Lymphocytes*
;
Th2 Cells
;
Treponema denticola*
;
Treponema*
8.Influence of Phenilamine on Pressor Responses of Norepinephrine and Tyramine.
Won Shik KIM ; Jae Whan JUNG ; Kum Suk JANG ; Soon Pyo HONG ; Kun Kook CHO ; Cheol Hee CHOI ; Dong Yoon LIM
Korean Circulation Journal 1985;15(1):125-137
The effect of Pheniramine(Avil), a histaminergic-1 receptor blocking agent presently employed in treating various allergic diseases on pressor actions of norepinephring(NE) and tyramine (TR) was studied in the rabbit. Pheniramine, when given into a femoral vein with a dose(3mg/kg) enough to block H1-receptor, potentiated markedly the pressor responses of NE and TR. The pressor action of NE augmented by pheniramine was not affected by additional adminstration of debrisoquin (Drenergic neuron blocker) or phenelzine(monoamine oxidase inhibitor) or desipramine(U1-uptake blocker), or while potentiated by additional treatment with chlorisondamine(ganglionic blocker)or reserpine(catecholamine depleter). The hypertensive response of NE to phenelzine or desipramine was reinforced significantly by addition of pheniramine, but the response of NE in rabbits treated with reserpine or chlorisondamine or debrisoquin was not influenced by pheniramine-addition. Elevation of blood pressure to TR potentiated by pheniramine was attenuated significantly by reserpine treatment with chlorisondamine made the significant augmentation of pressor action to TR after pheniramine. Tyramine-induced response of blood pressure after pheniramine, but the response of blood pressure to TR caused by phenelzine or desipramine was enhanced markedly by pheniramine-treatment. From the above experimental results, it is thought that the pressor effect of NE and TR potentiated by pheniramine is similar to that of debrisoquin, i.e. the sensitization of effector cell, and that central action of pheniramine can not ruled out.
Blood Pressure
;
Chlorisondamine
;
Debrisoquin
;
Desipramine
;
Femoral Vein
;
Neurons
;
Norepinephrine*
;
Oxidoreductases
;
Phenelzine
;
Pheniramine
;
Rabbits
;
Reserpine
;
Tyramine*
9.Effects of Vancomycin, Roxithromycin, and Rifampin on Biofilm Formed by Staphylococcus epidermidis.
Yong Seong LIM ; Yang Ree KIM ; Jung Hyun CHOI ; Jin Hong YOO ; Wan Shik SHIN ; Moon Won KANG
Korean Journal of Infectious Diseases 1999;31(4):317-324
BACKGROUND: Catheter-associated peritonitis occurs frequently in patients with chronic renal failure with peritoneal dialysis. It can be controlled by antibiotics, but relapses are common due to biofilms that affect the pathogenesis of peritonitis. This study was designed to evaluate the efficacy of antibiotics against biofilm formed by Staphylococcus epidermidis which is the most common causative organism of peritonitis in patients with peritoneal dialysis. METHODS: After incubation of silastic plates for 24 hours in peritoneal dialysis fluid containing S. epidermidis, the establishment of bacterial biofilm on the plates was confirmed by scanning electron microscopy. Then the plates were incubated in dialysate containing various concentrations of antimicrobial agents, such as vancomycin, roxithromycin or rifampin, in combination or alone. The quantification of organisms on silastic plates was performed for evaluation of antibiotic efficacy against biofilm formed by S. epidermidis after getting samples of plates at 0 hour, 4, 24, and 48 hours after incubation. RESULTS: The reduction of colony counts in groups with antibiotics was significantly larger than that in the control group and the difference was increased as time passed. In vancomycin treated plates, the colony count per plate for 2xMIC (minimal inhibitory concentration) was significantly lower than that for 1/8xMIC or 1/64xMIC at 4 hour, but no significant differences were noted at 24 hours and 48 hours among those of the various concentrations. The reduction of colony counts in accordance with concentrations of roxithromycin was not significantly different at 4 hours, but the reduction for 1/8xMIC was larger than that for 1/64xMIC at 24 hours and 48 hours. The reduction of colony counts in accordance with concentrations of rifampin was not significantly different at 4 hours, but the reduction for 1/8xMIC was larger than that for 1/64xMIC at 24 hours and 48 hours. There was no significant difference in reduction of colony counts between groups of anti-biotic combination containing vancomycin and groups of vancomycin alone. CONCLUSIONS: It is suggested that the sub-inhibitory concentrations of vancomycin, roxithromycin, and rifampin might be effective on biofilm-forming S. epidermidis in in vitro model of infection related with peritoneal dialysis catheter. This result may be applicable for development of a new method to control biofilm-associated peritonitis during peritoneal dialysis.
Anti-Bacterial Agents
;
Anti-Infective Agents
;
Biofilms*
;
Catheters
;
Humans
;
Kidney Failure, Chronic
;
Microscopy, Electron, Scanning
;
Peritoneal Dialysis
;
Peritonitis
;
Recurrence
;
Rifampin*
;
Roxithromycin*
;
Staphylococcus epidermidis*
;
Staphylococcus*
;
Vancomycin*
10.Anterior Lumbar Interbody Fusion for Focal Type of Degenerative Flat Back: Preliminary Report.
Chan Shik SHIM ; Sang Ho LEE ; Sang Rak LIM ; Byung Ju JUNG ; Won Chul CHOI ; Sang Ki CHUNG
Journal of Korean Neurosurgical Society 2003;33(5):460-465
OBJECTIVE: The purpose of this study is to determine the efficacy of anterior lumbar interbody fusion(ALIF) for the patients with focal type of degenerative flat back. METHODS: The authors reviewed clinical and radiologic data of 16 patients with focal type of degenerative flat back who underwent ALIF during the period between December 1999 and November 2000. The operation procedure was ALIF using titanium or carbon fiber cages of lordotic angle, which were filled with allograft or autograft mixed with allograft through minilaparotomy. RESULTS: The majority of the patients were female(15 female: 1 male) and the mean age was 60.1 years. Six patients were operated on one level, ten on two levels. The mean follow up period was 10.7 months. The mean operation time was 131minutes and the average estimated blood loss was 133ml. Transfusion was not needed in any case. The mean preoperative lumbar lordotic angle was 4.1 degree(-7.4-41.6) and improved to 17.5 degree(-4.5-41.9) postoperatively. Radiological fusion was achieved in 13 patients(81%). The Oswestry disability index score improved from 62.5% to 23.9% and the patient's subjective improvement rate was 80%. Complications were infection in one patient, incisional hernia in one, symptomatic pseudoarthrosis in one and transient sympathetic disturbance in left leg in three. CONCLUSION: In a subset of the patients with degenerative flat back who showed disc degeneration in one or two levels, ALIF using cages improved patient's symptoms effectively. It seems that ALIF through minilaparotomy can be one of the surgical options in the treatment of the focal type of degenerative flat back.
Allografts
;
Autografts
;
Carbon
;
Female
;
Follow-Up Studies
;
Hernia
;
Humans
;
Intervertebral Disc Degeneration
;
Laparotomy
;
Leg
;
Pseudarthrosis
;
Titanium