The aims of study presented here were to determine dose-dependent effects of UVB irradiation on CHS reaction and comparative effects of VVB on the induction and elicitation in guinea pigs. Pre-induction exposure to either suberythemal or supraerythemal doses of UVB resulted in suppreasion of CHS (53.47% & 57.64%) campared to positive control (79. 86%) However, suberythemal doses of UVB generated a more potent suppression than supraerythemal doses. Pre-elicitation exposure to suberythemal doses of UVB on the elicitation sites and adjacent to elicitation sites resulted in suppressed CHS reactions in both groups (60.4zg & 56.25p,). When the reaction by UVB was eliminated from the cutaneous reaction elicited in guinea pigs sensitized to DNCB, by UVB irradiation on the adjacent to elicitation sites, generated a more potent suppression than that UVB was directly irradiated on the elicitation sites.
Animals ; Dermatitis, Contact* ; Dinitrochlorobenzene* ; Guinea Pigs* ; Guinea*

No abstract available.
Acute Kidney Injury* ; Nifedipine* ; Plasma* ; Renin*

Recent studies have revealed that IGF- I produced in kidney are of two fractions; GH dependent and GH nondependent IGF-I. The role of GH nondependent IGF-I is interesting in renal hypertrophy and glomerulosclerosis because GH is clearly related with hypertrophy accompanying glomerulosclerosis is not seen in GH deficient animal. The relationship of the high protein diet and the IGF- I production under the deprivation of GH was studied. In hypophysectomized Sprague-Dawley rat, the level of serum IGF-I was measured using radioimmunoassay, and renal IGF- I production evaluated by immunohistochemistry during both normal and high protein diet. Serum IGF-I of rats on high protein diet was significantly higher than that fed normal protein diet. After unilateral nephrectomy, the level of serum IGF-I was significantly increased in both normal and high protein diet groups. Henle's loop, distal convoluted tubule and collecting duct were weakly stained with normal protein diet. With high protein diet, the staining intensities increased at these portion , and distal part of proximal convoluted tubule and straight tubule were weakly stained. After unilateral nephrectomy, distal convoluted tubule and collecting duct were densely stained with normal protein diet. With high protein diet, the staining intensities increased in distal part of proximal convoluted tubule and Henle's loop. Regardless of the types of protein diet, the specific difference between unilateral nephrectomized rats and sham- operated rats was immunoreactivity of the distal convoluted tubule.. In conclusion, it is suggested that GH non-dependent IGF-I is mainly produced in distal convoluted tubule during compensatory renal hypertrophy, and protein diet mainly affect IGF- I production of distal part of proximal convoluted tubule and Henle's loop.
Animals ; Diet ; Growth Hormone* ; Hypertrophy ; Hypophysectomy ; Immunohistochemistry ; Insulin-Like Growth Factor I ; Kidney* ; Nephrectomy ; Radioimmunoassay ; Rats ; Rats, Sprague-Dawley

A clinical observation was made on 70 nephrectomized patients during the period from Jan, 1978 to June, 1981. The results were as follows. 1. The total number of inpatients during the period was 1,122 and nephrectomies were performed in 70 of the 744 total urologic operations (9.4%). 2. The age distribution showed the highest in 5th decade with 25.7% and the youngest case was observed at the age of 3, the oldest at 68 and 43 males and 27 females with male to female ratio 1.6:1. 3. The causative diseases of nephrectomy were tuberculosis (25.7%), renal stone (24.3%), renal injury (14.3%), renal tumor (10.0%) and hydronephrosis (8.0%) etc. 4. Percentage of nephrectomy in each disease were 39.1% in tuberculosis, 22.7% in renal stone, 31.3% in renal injury, 77.9 % in renal tumor and 50.0 % in hydronephrosis. 5. Surgical approaches consisted of frank subcostal approach in 38.6%, anterior abdominal extraperitoneal approach in 35.7 % and abdominal transperitoneal approach in 25.7 %. 6. Among the transfused patients who nephrectomized, the average amount of transfused whole bleed were 1757 ml on renal tumor, 1320 ml in renal injury, 700 ml in renal stone and 533 ml in renal tuberculosis. 7. Postoperative complications were postoperative bleeding in 3 cases, wound infection in 2 cases, paralytic ileus in 2 cases, wound disruption in 1 case, uremia in 1 case and upper G-I bleeding in 1 case.
Age Distribution ; Female ; Hemorrhage ; Humans ; Hydronephrosis ; Inpatients ; Intestinal Pseudo-Obstruction ; Male ; Nephrectomy ; Postoperative Complications ; Tuberculosis ; Tuberculosis, Renal ; Uremia ; Wound Infection ; Wounds and Injuries

This survey was to elucidate the bacterial clearance time (BCT) among the patient of L-type and B-group leprosy who had been und.er chernotherapy and foll- ow up with bacterial examination 4 times every year more than 3 years at the Chronic Disease Laboratory of Catholic Medical College. The 99 patients, 53 L-type and 46 B-group, were slected for this study. These patients were classified again into 2 groups: 80 patients with negative bacterial index and 19 patient of posit.ive bacterial index. The patient with negative bacterial index was subdivided into 3 groups by BCT. 1. Rapid decrease group (RA group) BCT<(4years) 2. Standard decrease group (ST group) 4BCT<7 R. Slow decrease group (SL group) 7.
Chronic Disease ; Drug Therapy* ; Humans ; Leprosy* ; Leprosy, Borderline* ; Leprosy, Lepromatous* ; Prognosis*

To find out the good visual environment for reading, the methods of illumination were studied using Arden Contrast Sensitivity System. Among various factors for comfortable reading condition such as air condition, temperature, humidity, noise and light, the intensity and characters of illumination were the most important factors for eye health. If the character of illuminations are fairly good, to make the brighter condition is better for eye hdalth. But in artificial illumination, there are so many limitations for supplying light of good characters. So we set the luminosity on the desk to 500 lx in which tbe best visual acuity presented, and checked the contrast sensitivity by changing the luminosity of the room. The results suggested that the condition in which luminosity on the desk was higher twice than the room was favorable for reading.
Contrast Sensitivity* ; Humidity ; Lighting* ; Noise ; Visual Acuity

A clinical observation was made on 20 patients with renal tumor who had been admitted to Department of Urology, Jeonbug National University Hospital during the period from January 1978 to March 1983. The following results were obtained. 1. The incidence of renal tumor among total 1892 inpatients was 1.1% and 5.1% among the 389 genitourinary tumors. The most prevalent age group was fifth decade. The sex ratio, male to female was 1.5:1. 2. Histopathological analysis showed renal cell carcinoma in 11 cases, transitional cell carcinoma in 2 cases, squamous cell carcinoma in I case, Wilms' tumor in 1 case, neuroblastoma in 1 case, hemangioma in I case and simple cyst in 3 cases. 3. The most frequent symptoms and signs were gross hematuria in 11 cases(55%), flank pain in 11 cases(55%) and palpable mass in 6 cases (30%), and these classical symptom triad were seen in 3 cases of renal cell carcinoma. 4. Renal angiography was performed in 9 patients with 6 cases of renal cell carcinoma, 1 case of transitional cell carcinoma, 1 case of hemangioma and 1 case of renal cyst. 5. At the time of diagnosis, distant metastasis were found in 2 cases with renal cell carcinoma to lung, spine and Virchow's node. 6. Treatment of renal tumors consisted of surgery, radiation and/or chemotherapy. Radical nephrectomy was performed in 10 cases, simple nephrectomy in 2 cases, nephroureterectomy with bladder cuff resection in 3 cases, renal cystectomy with marsupialization in 3 cases and only diagnosis in 2 cases.
Angiography ; Carcinoma, Renal Cell ; Carcinoma, Squamous Cell ; Carcinoma, Transitional Cell ; Cystectomy ; Diagnosis ; Drug Therapy ; Female ; Flank Pain ; Hemangioma ; Hematuria ; Humans ; Incidence ; Inpatients ; Jeollabuk-do ; Lung ; Male ; Neoplasm Metastasis ; Nephrectomy ; Neuroblastoma ; Sex Ratio ; Spine ; Urinary Bladder ; Urology ; Wilms Tumor

A clinical observation was made on the 7 cases of ureteropyeloplasty secondary to ureteropelvic junction obstruction during the period from July, 1980 to January, 1982 and brief review of literature was made. 1. Hydronephrosis secondary to obstruction at the ureteropelvic junction was caused by congenital ureteropelvic junction stricture in 4 cases, aberrant vessels in 1 Case and combined cases in 2 cases. 2. The youngest age was 15 year old and the oldest 53 year old. The ratio of male to female and left to right were 3:4 and 2:1. 3. The types of ureteropyeloplasty were Anderson-Hynes pyeloplasty in 5 cases, Sand Cormoily tube-flap pyeloplasty in 1 case and nondismembered pyeloplasty with elimination of aberrant vessels in 1 case. 4. Multiple holed stent was used in all cases. 5. Postoperative complications were developed in2 cases, which were intractable urinary leakage and restricture and were treated by nephrostomy and nephrectomy respectively. 6. Follow up study was performed in 6 cases. Among 7 cases of ureteropyeloplasty, good results included in 4 cases, fair in 1 case and poor in 2 cases.
Adolescent ; Constriction, Pathologic ; Female ; Follow-Up Studies ; Humans ; Hydronephrosis ; Male ; Middle Aged ; Nephrectomy ; Postoperative Complications ; Silicon Dioxide ; Stents

Fourteen cases of central retinal vein occlusion (CRVO) were studied with electroretinogram (ERG) and fluorescein angiogram. The cases were divided into a venous stasis retinopathy group (VSR,9 cases) and a hemorrhagic retinopathy group(HR, 5 cases). The b/a ratio and retinal circualtion time (RCT) were measured and compared with the control group. The mean b/a ratio of the HR group (0.86) was decreased as compared with the VSR group (1.18) and the control group (1.23). The RCT of the HR group was markedly delayed to 13.68 seconds as compared with the VSR group (11.09 sec) and the control group (6.4 sec). These facts suggest that both the b/a ratio and the RCT are possible parameters for estimating retinal ischemia and that the ERG is a reliable examination method for classification of CRVO.
Adult ; *Electroretinography ; Female ; Fluorescein Angiography ; Humans ; Male ; Middle Aged ; Retinal Vein Occlusion/diagnosis/*physiopathology ; Retinal Vessels/*physiopathology ; Time Factors

PURPOSE: The objective of this study was to evaluate an immunoassay for urinary nuclear matrix protein (NMP22) as an indicator for transitional cell carcinoma of the bladder. MATERIALS AND METHODS: Three groups of subjects attended the trial of NMP22. First group was 27 patients with transitional cell carcinoma of the bladder, second group was 24 patients with other urinary cancer consisted of prostate cancer and renal cell carcinoma, and third group was 24 healthy volunteers. NMP22 was determined using a commercial test kit, which is based on an enzyme-linked immunosorbent assay. RESULTS: In normal healthy volunteers and other urinary cancer group median NMP22 levels were 2.24 and 3.27 U/ml, respectively. Median urinary NMP22 levels in patients with transitional cell carcinoma of the bladder were 54.30 U/ml. It was significantly greater than other two groups. Median NMP22 levels according to the tumor stage and the tumor grade did not show the significant difference statistically. CONCLUSIONS: Urinary NMP22 is a useful marker that is more specific for bladder cancer thsn for other urinary cancer. Further tests are required to clarify the influence of other spe- cific conditions, such as urinary tract infection, and intravesical drug instillation or procedure.
Carcinoma, Renal Cell ; Carcinoma, Transitional Cell* ; Enzyme-Linked Immunosorbent Assay ; Healthy Volunteers ; Humans ; Immunoassay ; Instillation, Drug ; Nuclear Matrix* ; Prostatic Neoplasms ; Urinary Bladder Neoplasms ; Urinary Bladder* ; Urinary Tract Infections