PURPOSE: To report a case of a patient with intractable scleritis with conventional immunosuppressive therapy who showed effective treatment with infliximab. CASE SUMMARY: A 71-year-old man presented with orbital cellulitis and diffuse anterior scleritis of his left eye. Although orbital cellulites showed remission with topical and systemic antibiotics, scleritis persisted despite a combination therapy of immunosuppressive agents (cyclosporin, mycophenolate, prednisolone) for 1 month. Finally, he was given infliximab (5 mg/kg) intravenously three times at 2-week intervals, after which ocular pain, chemosis, conjunctival injection, and sclera thickening considerably reduced, and scleritis completely remitted. CONCLUSIONS: The administration of Infliximab seems to be an effective therapy in patients with intractable scleritis undergoing conventional therapy.
Aged ; Anti-Bacterial Agents ; Antibodies, Monoclonal ; Eye ; Humans ; Immunosuppressive Agents ; Orbit ; Orbital Cellulitis ; Sclera ; Scleritis ; Infliximab