Posterior lip sclerectomies were performed in rabbits and cytosine arabinoside (Ara-C) was applied by topical instillation or subconjunctival injection. In both groups, the mean intraocular pressure (lOP) of the treated eyes was significantly lower at postoperative week 1 and 2, but there was no significant difference between the mean lOP of the control eyes and that of the treated eyes at postoperative week 3 and 4. In both groups, at postoperative week 2, the sclerectomy sites of the control eyes were totally occluded by granulation tissue, but those of the treated eyes partially replaced by granulation tissue At postoperative week 4, the sclerectomy sites of the treated eyes were totally occluded by the granulation tissue ultimately in both groups. There were no differences in the mean lOP and the histologic finding of the treated eyes between the topical instillation group and the subconjuctival injection gorup. We concluded that either topical instillation or subconjunctival injection of Ara-C can delay wound healing at the surgical site after glaucoma filtering surgery in rabbits.
Cytarabine* ; Cytosine* ; Filtering Surgery* ; Glaucoma* ; Granulation Tissue ; Intraocular Pressure ; Lip ; Rabbits ; Wound Healing* ; Wounds and Injuries*

Posterior lip sclerectomies were performed in rabbits and cytosine arabinoside (Ara-C) was applied by topical instillation or subconjunctival injection. In both groups, the mean intraocular pressure (lOP) of the treated eyes was significantly lower at postoperative week 1 and 2, but there was no significant difference between the mean lOP of the control eyes and that of the treated eyes at postoperative week 3 and 4. In both groups, at postoperative week 2, the sclerectomy sites of the control eyes were totally occluded by granulation tissue, but those of the treated eyes partially replaced by granulation tissue At postoperative week 4, the sclerectomy sites of the treated eyes were totally occluded by the granulation tissue ultimately in both groups. There were no differences in the mean lOP and the histologic finding of the treated eyes between the topical instillation group and the subconjuctival injection gorup. We concluded that either topical instillation or subconjunctival injection of Ara-C can delay wound healing at the surgical site after glaucoma filtering surgery in rabbits.
Cytarabine* ; Cytosine* ; Filtering Surgery* ; Glaucoma* ; Granulation Tissue ; Intraocular Pressure ; Lip ; Rabbits ; Wound Healing* ; Wounds and Injuries*

PURPOSE: To assess the proper differential diagnosis and treatment of scleritis with scleral melt following pterygium excision. METHODS: A retrospective study through a review of medical records of 5 patients diagnosed with surgically induced necrotizing scleritis (SINS) after pterygium excision and treated with systemic immunosuppressant and steroid. RESULTS: All the patients responded to the treatment and showed significant improvement. CONCLUSIONS: Immunosuppressive treatment without surgical intervention is effective in resolution of SINS after pterygium excision.
Diagnosis, Differential ; Humans ; Medical Records ; Pterygium* ; Retrospective Studies ; Scleritis*

Polymorphonuclear leukocytes(PMNs) infiltrate to the wound site within a few hours after excimer laser photorefractive keratectomy(PRK). Oxygen free radicals produced by the PMNs may be injurious to the surrounding corneal tissues and also acts as an inflammatory mediator that deepen tissue damage. In this study we examined that the application of ascorbic acid would decrease corneal haze following excimer laser PRK. Excimer laser PRK was done in 9 rabbits (18 eyes). Ascorbic acid was injected subconjunctivally in one eye and BSS was injected in the opposite eye. The corneal epithelium re-surfaced by 2.6 +/- 0.5 days in the ascorbic acid treated group and by 2.7 +/- 0.7 days in the ESS injected group. Corneal hazes examined in postop 2wk, 4 wk, 6 wk, and 8 wk were 1.6 +/- 0.5, 1.4 +/- 0.5, 0.7 +/- 0.3, 0.5 +/- 0.2 in the ascorbic acid treated group and 2.1 +/- 0.6, 1.7 +/- 0.5, 1.1 +/- 0.3, 0.9 +/- 0.2 in the BSS injected group, respectively. These data suggest that ascorbic acid would decrease corneal haze after excimer laser PRK without significant complications.
Ascorbic Acid* ; Epithelium, Corneal ; Free Radicals ; Lasers, Excimer* ; Oxygen ; Rabbits* ; Wounds and Injuries

The visual, refractive, and keratometric results of radial keratotomies(RK) in 10 high myopic eyes over 10 diopters(D) were evaluated. The mean follow-up period was 6.7 months with a range of 3 to 12 months. Before surgery, the mean spherical equivalent(SE) was -16.8 D and the postoperative mean change in SE was 7.9 D. The postoperative uncorrected visual acuity and corrected visual acuity with tolerable glasses were improved in all cases and 4 cases of them resulted in improved best-corrected visual acuity. The RK seemed to be a safe and effective procedure for the eyes with high myopia over 10 D to get better corrected visual acuity with the tolerable glasses as well as the eyes with moderate myopia to be closer to emmetropia.
Emmetropia ; Eyeglasses ; Follow-Up Studies ; Glass ; Keratotomy, Radial* ; Myopia* ; Visual Acuity

The intraocular pressure (IOP) in 115 cases of extracapsular cataract extraction (ECCE) and ciliary sulcus fixation of posterior chamber lens implantation was measured more than 2 months postoperatively. These results were compared to the unoperated fellow eyes, as well as to a group of 14 patients who had ECCE and implantation of an anterior chamber lens. The posterior chamber lens implanted eyes demonstrated a significant IOP reduction after surgery compared to the unoperated fellow eyes and the anterior chamber lens implanted eyes. In the posterior chamber lens implanted eyes, there was a significant IOP reduction after surgery in all age groups and there was a significant IOP reduction in the eyes with a 2 to 6 months and a 7 to 12 months follow-up after surgery, but no IOP change in the eyes with more than 1 year follow-up after surgery. We concluded that in the case of ECCE and ciliary sulcus fixation of posterior chamber lens implantation, IOP was initially reduced after surgery, but approarhed the preoperative level over a period of time.
Adult ; Aged ; *Cataract Extraction ; Female ; Humans ; *Intraocular Pressure ; *Lenses, Intraocular ; Male ; Middle Aged

I analyzed the incidence of fibrinous membrane formation in the eyes that received extracapsular cataract extraction and posterior chamber lens implantation. There was statistically significant difference between the incidence of fibrinous membrane formation in the eyes that received sub-Tenon's injection of Depo-Medrol(R) at the end of surgery(7.9%) and that in the eyes that did not receive it(34.8%)(p<0.025).
Cataract Extraction ; Fibrin* ; Incidence ; Membranes*

115 cases of extracapsular cataract extraction(ECCE) and ciliary sulcus fixation of posterior chamber lens implantation had intraocular pressure(IOP) measurements recorded more than 2 months postoperatively. These results were compared to the unoperated fellow eyes, as well as to a group of 14 patients who had ECCE and implantation of an anterior chamber lens. The posterior chamber lens implanted eyes demonstrated a significant IOP reduction after surgery compared to the unoperated fellow eyes and the anterior chamber lens implanted eyes. In the posterior chamber lens implanted eyes, there was a significant IOP reduction after surgery in all age groups and there was a significant IOP reduction in the eyes with from 2 to 6 months and from 7 to 12 months follow-up after surgery, but no IOP change in the eyes with more than 1 year follow-up after surgery. We concluded that in the cases of ECCE and ciliary sulcus fixation of posterior chamber lens implantation, IOP was reduced a while after surgery, but approached to preoperative level as time went on.
Anterior Chamber ; Cataract Extraction* ; Cataract* ; Follow-Up Studies ; Humans ; Intraocular Pressure*

The visual, refractive, and keratometric results of radial keratotomies (RK) in 10 high myopic eyes of over 10 diopters(D) were evaluated. The mean follow-up period was 6.7 months with a range of 3 to 12 months. Before surgery, the mean spherical equivalent(SE) was -16.8 D and the postoperative mean change in SE was 7.9 D. In all cases postoperative uncorrected visual acuity and corrected visual acuity with tolerable glasses were improved. In 4 of the cases, best-corrected visual acuity was improved as well. RK appears to be a safe and effective procedure for eyes with high myopia of over 10 D to achieve better corrected visual acuity than with corrective lenses as well as for eyes with moderate myopia to be closer to emmetropia.
Adolescent ; Adult ; Child ; Cornea/surgery ; Female ; Humans ; *Keratotomy, Radial ; Male ; Middle Aged ; Myopia/*surgery ; Refraction, Ocular ; Visual Acuity

Posterior lip sclerectomies were performed in rabbits and cytosine arabinoside (Ara-C) was applied by topical instillation or subconjunctival injection. In both groups, the mean intraocular pressure (IOP) of the treated eyes was significantly lowered at postoperative week 1 and 2, but there was no significant difference between the mean IOP of the control eyes and that of the treated eyes at postoperative week 3 and 4. In both groups, at postoperative week 2, the sclerectomy sites of the control eyes were totally occluded by granulation tissue, but those of the treated eyes were partially replaced by granulation tissue. At postoperative week 4, the sclerectomy sites of the treated eyes were totally occluded by the granulation tissue ultimately in both groups. There were no differences in the mean IOP and the histologic finding of the treated eyes between the topical instillation group and the subconjunctival injection group. We concluded that either topical instillation or subconjunctival injection of Ara-C can delay wound healing at the surgical site after glaucoma filtering surgery in rabbits.
Administration, Topical ; Animals ; Conjunctiva ; Cytarabine/*administration & dosage/therapeutic use ; Glaucoma/pathology/*surgery ; Injections ; Intraocular Pressure/drug effects ; Ophthalmic Solutions ; Rabbits ; *Sclerostomy ; Wound Healing/drug effects