No abstract available.

No abstract available.
Antibodies, Monoclonal* ; Humans*

No abstract available.
Embryonic Structures* ; Head* ; Humans* ; Neck*

Psoriasis is common cutaneous disorder involving 0.1~3% Of the general population and is characterized by its marked chronicity and recurrence. A variety of factors, rarging from heredity, environment to abnormal cytodynamics and biochemical perturbation have been implicated but never proved as causative. In recent years, many studies on psoriasis have been reported, showing the presence of certain immunologic abnormalities in patients with psoriasis, and some authors postulated that these immunologic abnormalities, particularly in cell mediated immunity, may play a key role in the pathogenesis of psoriasis. This study was undertaken to evaluate cell mediated immune status of patients with paoriasis using several immunologic parameters. A total of 70 patients (35 were male and 35 were female) between the ages of l:l and 70 years entered this study at the Department of Dermatology of Seoul National University Hospital from January 1980 through September 1980. Peripheral blood T lymphocytes(early and total) were enumerated by E-rosette technique in 55 patients. Delayed cutaneous hypersensitivity reaction was measured in 3O patients using intradermal candidin, trichophytinand PPD. Active sensitization with DNCB was performed in 30 patients.
Dermatology ; Dinitrochlorobenzene ; Heredity ; Humans ; Hypersensitivity ; Immunity, Cellular ; Male ; Psoriasis* ; Recurrence ; Seoul

anserine folliculosis (Padilha-Gonqalves, 1977) is a skin disease occurring on the limited areas of the skin receiving prolonged friction and/or pressure by the other part(s) of the naked skin of the patient. Padilha-Goncalves named traumatic anserine folliculosis by stressing the etiologic factor, the pressure and friction, the goose skin appearance and the follicular nature of the basic skin lesions. A 7-year-old girl developed typical features of traumatic anserine folliculosis on the chin who had the habit of resting the chin on the right knee for 5 years while painting.

No abstract available.
Animals ; Guinea Pigs* ; Guinea* ; Langerhans Cells*

BACKGROUND: IL-4 is known as a potent stimulating factor and, TNF-α and IFN-γ suppress collagen synthesis of dermal fibroblasts. However, relatively little is known about interaction of these cytokines. OBJECTIVE: The purpose of this study was to evaluate the interactional effect of TNF-α and INF-r for the type I collagen gene expression and promoter activation produced by IL-4. METHODS: Using dermal fibroblasts from the normal skin cultured with three cytokines, IL-4, TNF-α and IFN-γ, we examined Northern blot analysis with each cDNA and assayed CAT activity with human pro a 2(l)collagen(COL1A2)/CAT reporter gene chimeric construct. RESULTS: Compared to the control, treating with IL-4 resulted in prominent elevation of both type I procollagen mRNA levels and prce 2(I) collagen promoter activity. IL-4 with TNF-α suppressed the IL-4 induced elevations, whereas IL-4 with IFN-γ did not reveal the obvious suppression of the elevations produced by IL-4. Fibroolasts treated with IL-4 together with IFN-γ and TNF-α completely abolished the type I procollagen gene expression and the activation of COL1A2 promoter gene elicited by IL-4. CONCLUSION: IL-4 induced enhancement of type I collagen gene expression was synergistically suppressed by TNF-α and IFN-γ on transcriptional level.
Animals ; Blotting, Northern ; Cats ; Collagen ; Collagen Type I ; Cytokines ; DNA, Complementary ; Fibroblasts* ; Gene Expression ; Genes, Reporter ; Humans* ; Interleukin-4* ; Necrosis* ; RNA, Messenger ; Skin*

This study was undertaken to investigate mineral changes in weathered scalp hair after burial. EDX (energy dispersive X-ray spectroscopy) analysis was performed to measure the presence of minerals on the hair surface. Twelve scalp hairs, buried for 5-40 years, were chosen from deceased individuals buried in tombs in Soha-Ri, Kyonggi-Do, and other regions in Korea. Three normal hairs were used as the control group. EDX data showed that carbon, oxygen, and sulfur were detected in hair collected from all three burial grounds. In contrast, calcium was only detected in hair collected from tombs in Soha-ri. The amounts of calcium and sulfur were found to decrease with time for hair collected from tombs in Soha-ri. Similar results were observed with sodium for hair collected from other regions. These results show region specific mineral detection and a decrease in the concentration of minerals with time. Consequently, it is suggested that changes in minerals concentration in weathered hair could be used as basic data in the field of forensic medicine.
Burial ; Calcium ; Carbon ; Forensic Medicine ; Forensic Sciences ; Hair ; Humans ; Korea ; Minerals ; Oxygen ; Scalp ; Sodium ; Spectrometry, X-Ray Emission ; Sulfur ; Weather

No abstract available.
Drainage* ; Lung Abscess* ; Lung* ; Pneumothorax* ; Suppuration*

Chronic mucocutaneous randidiasis is a clinical syndrome characte ized by chronic and reccurent superficial candidal infection of the skin, mucous membranes, and nails. This syndrome is frequently associated with immune deficiency or endocrinopathy, especially hypopar; thyroidism. We report a case of chrcinic mucocutaneous candidiasis associated with hypoparathyroidism in a 8- year-old girl.
Candidiasis ; Candidiasis, Chronic Mucocutaneous* ; Female ; Humans ; Hypoparathyroidism* ; Mucous Membrane ; Skin ; Thyroid Gland