1.Two cases of extramammary Paget's disease: associated with adenocarcinoma with metastases.
Soo Keun PARK ; Jun Young LEE ; Ik Jun KO ; Si Yong KIM ; Won HOUH
Korean Journal of Dermatology 1991;29(2):256-260
We report two cases of extramammary Paget's disease associated with ad enocarcinoma with metascases. Histologically, Iaget cells in the epidermis and the hair follicles and adenocarcinoma in the der mis was observed in both cases. Of special interest was the demonstration of Eaget cells extending from the involved epidermis to the underlying dermis in case 2, There were metastatic lesioris of 3rd lumbar vertebra in case 1 and of the liver and lymph nodes in rase 2.
Adenocarcinoma*
;
Dermis
;
Epidermis
;
Hair Follicle
;
Liver
;
Lymph Nodes
;
Neoplasm Metastasis*
;
Paget Disease, Extramammary*
;
Spine
2.A Case of Targetoid Hemosiderotic Hemangioma.
Jong Rok LEE ; Si Won LEE ; Gwang Seong CHOI ; Seung Chul LEE ; Young Keun KIM
Annals of Dermatology 2001;13(4):228-231
Targetoid hemosiderotic hemangioma is a benign vascular tumor with a peculiar clinical presentation and histologic features sometimes difficult to differentiate from the patch stage of Kaposi's sarcoma, progressive lymphangioma, eosinophilic hemangioma, retiform hemangioendothelioma. We report a case of targetoid hemosiderotic hemangioma on upper back and right upper arm of a 28-year-old male. He has a 5mm × 5mm sized slightly raised violaceous papule surrounded by an ecchymotic halo on upper back and right upper arm. We took a biopsy of the lesion and identified it as targetoid hemosiderotic hemangioma. This is a case of targetoid hemosiderotic hemangioma with typical clinical and histopathological findings.
Adult
;
Arm
;
Biopsy
;
Eosinophils
;
Hemangioendothelioma
;
Hemangioma*
;
Humans
;
Lymphangioma
;
Male
;
Sarcoma, Kaposi
3.Treatment of Neurosyphilis with Ceftriaxone in a Patient Infected with Human Immunodeficiency Virus.
Won Keun SI ; Kang Heum SUH ; Moon Hyoung LEE ; Bo Kyoung CHOI ; Jin Ah HWANG ; Choon Kwan KIM
Infection and Chemotherapy 2011;43(3):262-265
The optimal and alternative antimicrobial regimens to treat neurosyphilis in human immunodeficiency virus (HIV) infected patients remain controversial. Little is known concerning the efficacy of ceftriaxone. A 75-year-old heterosexual man visited an outpatient clinic due to incidentally detected positive serum Venereal disease research laboratory (VDRL) and Fluorescent treponemal antibody absorbed tests in routine preoperative checkup. Because of benzathine penicillin was unavailable to use, 4-week regimen with doxycycline was started. After 2 weeks doxycycline treatment, a severe headache suddenly occurred. Cerebrospinal fluid (CSF) analysis showed mild lymphocyte-dominant pleocytosis, increased protein, and weakly reactive VDRL test. ELISA for HIV antibody and Western blot assay revealed he is infected with HIV. Initial CD4+ T cell count was 220/mm3 and the load of HIV RNA was 5,200 copies/mL. The most probable diagnosis was deemed to be neurosyphilis, considering the possibilities of Jarisch-Herxheimer reaction or doxycycline-induced pseudotumor cerebri. In the absence of procaine penicillin G in our hospital, intravenous ceftriaxone was administered and highly active antiretroviral therapy was started. After 14days of treatment, the patient no longer had a headache and the CSF profile was improved. Additional follow-up CSF analysis was done 3months after treatment. CSF pleocytosis and protein level were decreased and the CSF VDRL was converted to negative. Ceftriaxone may be a good alternative in the treatment of neurosyphilis in HIV infected patient.
Aged
;
Ambulatory Care Facilities
;
Antiretroviral Therapy, Highly Active
;
Blotting, Western
;
Ceftriaxone
;
Cell Count
;
Doxycycline
;
Enzyme-Linked Immunosorbent Assay
;
Ethylenediamines
;
Follow-Up Studies
;
Headache
;
Heterosexuality
;
HIV
;
Humans
;
Leukocytosis
;
Neurosyphilis
;
Penicillin G Benzathine
;
Penicillin G Procaine
;
Pseudotumor Cerebri
;
RNA
;
Sexually Transmitted Diseases
4.A Case of Bullous Pemphigoid in infant.
Sung Joo LEE ; Si Won LEE ; Gwang Seong CHOI ; Young Keun KIM ; Soo Chan KIM
Korean Journal of Dermatology 2001;39(10):1192-1194
Bullous pemphigoid may, very rarely, occur in infants, although it is usually a bullous disease of the elderly which is characterized by subepidermal bullae on erythematous and normal skin. We describe an infant with severe subepidermal blistering disorder with typical features for bullous pemphigoid.
Aged
;
Blister
;
Humans
;
Infant*
;
Pemphigoid, Bullous*
;
Skin
5.A Case of Kinky Hair Disease.
Young Sub LEE ; Seok Won PARK ; Byung Ho CHA ; Baek Keun LIM ; Jong Soo KIM ; Won Soo LEE ; Dong Jin KIM ; Myung Soon KIM ; Kyou Nam CHO ; Si Houn HAHN
Journal of the Korean Child Neurology Society 2001;9(1):164-170
Kinky hair disease is X-linked recessive neurodegenerative disorder produced by defects in a gene(ATP7A) that encodes an intracellular copper-transporting ATPase. About 90-95% of the patients have a severe clinical course leading to death in early childhood. ATP7A mutations associated with Menkes disease show great variety from cytogenetic abnormalities to partial gene deletions to single base-pair changes. We experienced a 15 month-old boy with loss of developmental milestones, hypotonia, seizures and failure to thrive. On laboratory findings, the levels of serum copper and ceruloplasmin were low. Electron microscopy of hair illustrated pathognomic pili torti and other abnormalities such as trichorrhexis nodosa and trichoptilosis(longitudinal splitting of the shaft). Brain magnetic resonance image showed diffuse cerebral and cerebellar atrophy with tortousity of cerebral blood vessels. Genetic defect was evaluated. Our sequencing data on the amplified exon 19 of ATP7ase genomic DNA confirmed point mutation, G1255A, resulting in a glycine-to-arginine conversion. So, we report a brief view with the related literatures.
Adenosine Triphosphatases
;
Atrophy
;
Blood Vessels
;
Brain
;
Ceruloplasmin
;
Chromosome Aberrations
;
Copper
;
DNA
;
Exons
;
Failure to Thrive
;
Gene Deletion
;
Hair
;
Humans
;
Infant
;
Male
;
Menkes Kinky Hair Syndrome*
;
Microscopy, Electron
;
Muscle Hypotonia
;
Neurodegenerative Diseases
;
Point Mutation
;
Seizures
6.Treatment Outcomes of Septoplasty with Turbinate Surgery in Septal Deviation with Chronic Hypertrophic Rhinitis.
Yong Dae KIM ; Bo Su SUH ; Gil Sung CHO ; Si Youn SONG ; Seok Keun YOON ; Kei Won SONG
Yeungnam University Journal of Medicine 2001;18(2):199-207
BACKGROUND: Septoplasty with turbinate surgery is common surgical treatment in patients with septal deviation and chronic hypertrophic rhinitis. The aim of this study was to evaluation objective outcomes of septoplasty with turbinate surgery by analysis of subjective symptom score with objective acoustic rhinometric test before and after surgery, prospectively. MATERIALS AND METHODS: We reviewed 45 adult patients which were done septoplasty with bilateral turbinectomy or turbinoplasty and followed up at least 3 months by one rhinologist from November 1999 to April 2000, prospectively. We analyzed subjective symptom score, minimal cross-sectional area (MCA), C-notch cross-sectional area, and total volume of both nasal cavity before and after surgery. Correlation test was studied between symptom improvement and acoustic rhinometric results. RESULTS: Twenty nine cases were male and sixteen cases female. The average age was 26.9 year-old (range: 17 to 57 years). There was significantly improvement of symptom score in postoperative 3 months (p<0.05). There was significantly increased C-notch cross-sectional area and total volume in postoperative 3 months. Symptoms improvement were associated with acoustic rhinometric profiles, but, there was not significantly correlation. CONCLUSION: Septoplasty with turbinate surgery is considered to be effective for nasal obstruction in patients with septal deviation and turbinate hypertrophy. Acoustic rhinometric test is favorable objective test for evaluation of symptom improvement after septal surgery.
Acoustics
;
Adult
;
Female
;
Humans
;
Hypertrophy
;
Male
;
Nasal Cavity
;
Nasal Obstruction
;
Prospective Studies
;
Rhinitis*
;
Rhinometry, Acoustic
;
Turbinates*
7.Evaluation of therapeutic regimens for the treatment of Helicobacter pylori infection.
Don Haeng LEE ; Hyo Jin PARK ; Si Young SONG ; Se Joon LEE ; Won CHOI ; Yong Chan LEE ; Jae Bock CHUNG ; Jin Kyung KANG ; In Suh PARK ; Yong Hee LEE ; Ho Keun KIM
Yonsei Medical Journal 1996;37(4):270-277
Helicobacter pylori (H. pylori) is currently considered the most important exogenous factor in the genesis of gastritis and peptic ulcer disease. However, the optimum regimen for the eradication of H. pylori remains unclear. The purpose of this study was to evaluate the eradication rate of H. pylori, the side effects, and the patients' compliance with regard to various drug regimens. We also analyzed factors influencing the eradication of H. pylori. One hundred and eighty patients were included and divided into four groups: 42 patients (Group I) received tripotassium dicitrato bismuthate (240 mg b.i.d.), metronidazole (250 mg t.i.d.) and amoxicillin (500 mg t.i.d.) for 14 days; 55 patients (Group 2) received omeprazole (20 mg b.i.d.) and amoxicillin (1000 mg b.i.d.) for 14 days; 36 patients (Group 3) were treated with omeprazole (20 mg b.i.d.), metronidazole (250 mg t.i.d.) and amoxicillin (500 mg t.i.d.) for 14 days; and 47 patients (Group 4) received omeprazole (20 mg q.d.) and amoxicillin (500 mg t.i.d.) for 14 days and then tripotassium dicitrato bismuthate(240 mg b.i.d.) and nizatidine (150 mg q.d.) for 14 days. The diagnosis of H. pylori was made by histology. The eradication of H. pylori was defined both by histology (H&E and Giemsa stain) and by rapid urease test (CLOR) showing negative for H. pylori 4 weeks after the completion of therapy. Of the 180 patients, 95 patients had non-ulcer dyspepsia, 40 patients had gastric ulcer and 45 patients had duodenal ulcer. The eradication rate of H. pylori was highest (89.3%) in Group 3, as compared with Group 1 (68.9%), Group 2 (65.4%), and Group 4 (48.9%). The eradication rate was significantly higher in Group 3 than in Groups 2 and 4 (p< 0.05). There was no significant difference in the eradication rate among clinical diagnosis, sex and age. But, in the conventional triple therapy (Group 1), the eradication rate was higher in male (78.6%) than in female (46.2%). The side effects in order, were nausea (22.1%), dizziness (19.5%), abdominal pain (11.6%) and diarrhea (97%), and there was no difference among the drug regimens. The compliance of the patients was good (more than 80% irrespective of drug regimen). On the basis of these findings, the side effects of the drugs seemed minimal, and the compliance of patients was good irrespective of the drug regimen. In conclusion, the triple therapy with omeprazole, metronidazole and amoxicillin was the most effective regimen and could be recommended for H. pylori eradication.
Adult
;
Anti-Ulcer Agents/*therapeutic use
;
Antibiotics/*therapeutic use
;
Duodenal Ulcer/microbiology
;
Dyspepsia/microbiology
;
Female
;
Helicobacter Infections/*drug therapy
;
*Helicobacter pylori
;
Human
;
Male
;
Middle Age
;
Stomach Ulcer/microbiology
8.Acute Generalized Exanthematous Pustulosis.
Si won LEE ; Jong rok LEE ; Gwang seong CHOI ; Sang wahn KOO ; Joo heung LEE ; Seung chul LEE ; Young keun KIM
Korean Journal of Dermatology 2001;39(2):203-208
Acute generalized exanthematous pustulosis(AGEP) presents with the abrupt onset of a wide spread pustules on an erythematous base and rapid spontaneous healing. The most possible causes of AGEP seem to be antibiotics, viral infection and exposure to mercury. We report five cases of acute generalized exanthematous pustulosis, all of which presented wide spreaded tiny pustules on an erythematous base. Histopathologic examination showed that there are subcorneal pustules, rete ridge elongations and perivascular infiltration. We suspected that the possible causes of five cases were pharyngitis and various drugs each.
Acute Generalized Exanthematous Pustulosis*
;
Anti-Bacterial Agents
;
Pharyngitis
9.Case of a Metastatic Solitary Fibrous Tumor Presenting as Gastrointestinal Bleeding.
Kang Heum SUH ; Sung Hoon KIM ; Won Keun SI ; Moon Hyung LEE ; Bo Kyung CHOI ; Jin Ah HWANG ; Yangsoon PARK
Korean Journal of Medicine 2012;83(2):216-220
Metastatic cancers of the stomach are rare. Metastatic diseases of the stomach can occur with melanoma and other primary tumors of the breast, lung, ovary, liver, colon, and testis; however, breast cancer is the most common. Other rare malignant tumors that can involve the stomach include Kaposi's sarcoma, myenteric schwannoma, glomus tumor, small cell carcinoma, and parietal cell carcinoma. On the other hand, solitary fibrous tumors of the pleura are rare soft tissue sarcomas, and most are benign; however, 13 to 36% may be malignant. Metastases may occur in extrathoracic sites, such as the liver, central nervous system, spleen, adrenal gland, and bone. We herein report a case of a 75-year-old man with previously diagnosed brain and liver metastases. He developed a stomach metastasis from a malignant solitary fibrous tumor and presented with gastrointestinal bleeding symptoms.
Adrenal Glands
;
Aged
;
Brain
;
Breast
;
Breast Neoplasms
;
Carcinoma, Small Cell
;
Central Nervous System
;
Colon
;
Endoscopy
;
Female
;
Gastrointestinal Hemorrhage
;
Glomus Tumor
;
Hand
;
Hemorrhage
;
Humans
;
Liver
;
Lung
;
Melanoma
;
Neoplasm Metastasis
;
Neurilemmoma
;
Ovary
;
Pleura
;
Sarcoma
;
Sarcoma, Kaposi
;
Solitary Fibrous Tumors
;
Spleen
;
Stomach
10.A Case of Giant Brunner's Gland Hyperplasia Combined with Adenomyomatous Hyperplasia.
Joo Won CHUNG ; Joo Hee SEO ; Seung Woo PARK ; Si Young SONG ; Jae Bock CHUNG ; Sang Kyum KIM ; Ho Keun KIM ; Seungmin BANG
The Korean Journal of Gastroenterology 2008;52(6):384-388
Brunner's gland hyperplasia is a rare tumor of the duodenum and might also be an unusual cause of gastrointestinal bleeding. In symptomatic patients, treatment requires either surgical resection or endoscopic polypectomy. We report a case of upper gastrointestinal bleeding from a pedunculated Brunner's gland hyperplasia in the duodenal bulb. Endoscopic resection using the detachable snare and hemoclipping was instituted to remove a large pedunculated polyp. The pathologic diagnosis was Brunner's gland hyperplasia with adenomyomatous hyperplasia.
Adult
;
Brunner Glands/*pathology/surgery
;
Duodenum/*pathology
;
Gastrointestinal Hemorrhage/etiology
;
Humans
;
Hyperplasia/complications/diagnosis/pathology
;
Laparoscopy
;
Male
;
Precancerous Conditions/pathology
;
Stents