No abstract available.
Foreign Bodies* ; Statistics as Topic*

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the human polyomavirus JC virus. PML mainly occurs in immunocompromised patients. A 36-year-old man with no evidence of immunosuppresion presented seizures. MRI scans of brain showed multifocal lesions in the cerebral white matters. JC virus DNA was positive in the cerebrospinal fluid examined by JC virus PCR. We report a rare case of PML presenting as viral encephalitis that occurred in a healthy adult person.
Adult ; Brain ; Central Nervous System ; Demyelinating Diseases ; DNA ; Encephalitis, Viral ; Humans ; Immunocompromised Host ; JC Virus ; Leukoencephalopathy, Progressive Multifocal ; Magnetic Resonance Imaging ; Polymerase Chain Reaction ; Seizures ; Viruses

No abstract available.
Adult* ; Humans ; Liver* ; Sarcoma*

Calcium deposits in the basal ganglia and in the other areas of the brain may occur as idiopathic disease or secondary to metabolic disturbances including hypoparathyroidism. Fahr's syndrome is characterized by secondary cerebral calcification and variable clinical manifestations of movement disorder, cognitive impairment, and behavioral changes. We report a 48 year-old man with Fahr's syndrome due to idiopathic hypoparathyroidism who presented with recurrent epileptic seizures. Brain CT showed multiple calcifications of the Fahr type in the basal ganglia, thalami, cerebellar white matter and dentate nuclei, and centrum seiovale. Brain MRI diffusion-weighted image showed high signal intensity in the right anterior temporal region.
Basal Ganglia ; Brain ; Calcium ; Epilepsy ; Humans ; Hypoparathyroidism ; Movement Disorders

PURPOSE: The aim of this study was to examine effects of patient safety culture and burnout on safety management activities with a focus on clinical experience of nurses in general hospitals. METHODS: Self-administered questionnaires were given to nurses in a general hospital in C Province, and 107 questionnaires were used for final analysis. Collected data were analyzed using SPSS/WIN 21.0 Program for t-test, ANOVA, Pearson correlation coefficients, and multiple regression. RESULTS: The highest score as perceived by general hospital nurses for patient safety culture was for 'Immediate superior/Manager'(3.84), for burnout, the highest score was for 'Emotional exhaustion' (4.13), and for safety management activities, the highest score was for 'Prevention of infection' (3.96). Patient safety culture and safety management activities perceived by general hospital nurses showed significant positive correlations (r=.35 p<.001). The correlations between burnout and safety management activities perceived by the nurses showed significant negative correlations (r=-.37, p<.001). Results of hierarchical regression analysis conducted to identify factors that affect safety management activities showed that patient safety culture (β=.40 p<.001) was effective for controlling safety management activities. CONCLUSION: The findings indicate a need to build a patient safety culture that fits the characteristics and situations of various hospitals.
Hospitals, General* ; Humans ; Patient Safety* ; Safety Management*

Graves disease is the most common clinical feature of hyperthyroidism in childhood. Clinical manifestations include emotional lability, hyperactivity, tremor, excessive sweating, exophthalmos and weight loss. In Graves disease, osteoporosis could occur because of a disturbance of mineral homeostasis which rarely develops from reduced calcium absorption of the gastrointestinal tract and increased urinary calcium excretion related to an increased bone resorption. We report a case of Graves disease with spinal deformity caused by osteoporosis in a 12-year-old female who was presented with back pain, anterior neck mass and kyphosis. Laboratory findings revealed hyperthyroidsm, hypercalciuria in 24-hour urine and normal serum parathyroid hormone. On radiologic examination, multiple osteoporosis and a spinal compression fracture were observed. The bone mineral density was decreased at the hip and lumbar spine on the bone densitometry. After initiating antithyroid drug, calcitonin and vitamin D, she returned to a euthyroid state and her back pain was improved. Bone density was also increased one year later.
Absorption ; Back Pain ; Bone Density ; Bone Resorption ; Calcitonin ; Calcium ; Child ; Congenital Abnormalities ; Densitometry ; Exophthalmos ; Female ; Fractures, Compression ; Gastrointestinal Tract ; Graves Disease* ; Hip ; Homeostasis ; Humans ; Hypercalciuria ; Hyperthyroidism ; Kyphosis* ; Neck ; Osteoporosis* ; Parathyroid Hormone ; Spine ; Sweat ; Sweating ; Tremor ; Vitamin D ; Weight Loss

Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against N. caninum infection was evaluated in vitro and in vivo. Two major immunodominant surface antigens (NcSAG1 and NcSRS2) and two dense granule proteins (NcDG1 and NcDG2) of N. caninum tachyzoites were expressed in E. coli, respectively. An in vitro neutralization assay using polyclonal antisera raised against each recombinant antigen showed inhibitory effects on the invasion of N. caninum tachyzoites into host cells. Separate groups of gerbils were immunized with the purified recombinant proteins singly or in combinations and animals were then challenged with N. caninum. Following these experimental challenges, the protective efficacy of each vaccination was determined by assessing animal survival rate. All experimental groups showed protective effects of different degrees against experimental infection. The highest protection efficacy was observed for combined vaccination with NcSRS2 and NcDG1. Our results indicate that combined vaccination with the N. caninum recombinant antigens, NcSRS2 and NcDG1, induces the highest protective effect against N. caninum infection in vitro and in vivo.
Animals ; Antibodies, Protozoan/immunology ; Antigens, Protozoan/immunology ; Cercopithecus aethiops ; Coccidiosis/prevention & control ; Dose-Response Relationship, Immunologic ; Gene Expression ; Gerbillinae ; Neospora/*immunology ; Protozoan Vaccines/*immunology ; Research Support, Non-U.S. Gov't ; Vaccines, Synthetic/immunology ; Vero Cells

No abstract available.
Cerebral Infarction ; Fingers ; Infarction ; Muscle Weakness

OBJECTIVES: The purpose of this study was to examine the association between vitamin C, vitamin D, and periodontal diseases in adults. METHODS: The data used for analysis were obtained from the sixth Korean National Health and Nutrition Examination Survey (2013-2014). Subjects were 2,702 adults aged from 19 to 64 years. Complex Chi-square tests and complex logistic regression analyses were used to assess the association between vitamins and periodontal status. RESULTS: There is no statistically significant association between vitamin C intake and periodontal status. Periodontal status of subjects with a low vitamin D (25-hydroxyvitamin D) level was better than that of the subjects with a high level (P<0.05). However, multivariate analysis demonstrated that this association is not statistically significant. CONCLUSIONS: More follow-up studies are necessary to determine the association of the vitamins C and D with the periodontal diseases.
Adult ; Ascorbic Acid ; Cross-Sectional Studies* ; Follow-Up Studies ; Humans ; Logistic Models ; Multivariate Analysis ; Nutrition Surveys ; Periodontal Diseases ; Vitamin D ; Vitamins*

The PHIS(Public Health Information System) has been developed, and installed in public health centers nationwide since 1994. Ironically, however, even though infrastructures have been modernized, there is scant published material that has investigated the determinants of success of the PHIS. Therefore, these were evaluated in relation to the concern of user satisfaction, which was composed of overall satisfaction, usability, convenience and satisfaction for the supportive system. These satisfaction factors were also compared according to general user characteristics. The questionnaire response rate was 81.5%. The overall satisfaction and total Likert's scores, 3.078 +/- 0.634 and 3.005 +/- 0.563, respectively, showed that the end-users were relatively satisfied with the PHIS. Also, the overall satisfaction correlated most strongly with the convenience attribute. However, dissatisfaction strongly correlated with the supportive system, i.e. education and training facilities. This article describes our progress, and reports on the lessons learned, which will guide future work in this field.
Education ; Factor Analysis, Statistical* ; Information Systems* ; Iron ; Public Health* ; Surveys and Questionnaires