1. Napotol solution was topically applied on a trial basis for the treatment of superficial fungal infections and 56% of patients had an excellent benefit and 14% of patients had an irritant dermatitis during the treatment. 2. The main compoeition of Napotol solution is drived from ethsnolie extraction of a natural plant and it's pharmacological action to fungal infection is not known,, yet it's antifungal action is potent as compared to other antifungal topical medicines, Napotol solution also including salicylic acid and benzoic acid, which are well known as possessing a potent antifungal property, may be accelerating it's function for the treatment of superficial fungal infection.
Arthrodermataceae* ; Benzoic Acid ; Dermatitis, Irritant ; Humans ; Plants ; Salicylic Acid

The statistical survey on 148 patients with herpes zoster was made. Among 148 patients, 78 were treated with sublesional injection of predinisolone-procaine for severe neuralgic pain. 1) The incidence of herpes zoster was increasing with age, reaching it's height at age of 41-60 group and declining thereafter (Fig. 1). 2) The ratio of severe neuralgic pain of herpes zoster to the total incidence of every age groups was increasing with age, being 23.5% in the youngest age group under 10 and 85.7% in the eldest age group between 71-80 (Table 1). 3) The ratio of zoster peetoralis to the total incidence was 70% and a case of generalized herpes zoster associated with lymphocytic leukemia was observed. 4) 78 cases of herpes zoster suffering from the severe neuralgic pain were treated with sublesional injection of predinisolone-proicaine. The effect was excellent, shortening it's eours and relieving pain. There were so complications of hematogenous dissemination, skin infection and atrophy after the injection, except one case of hematogenous dissemination in lymphocytic leukemia.
Atrophy ; Herpes Zoster* ; Humans ; Incidence ; Leukemia, Lymphoid ; Procaine* ; Skin

PURPOSE: We collected the data of Science Citation Index (SCI) and SCI Expended (SCIE) papers written by the members of the Korean Society of Radiation Oncology (KOSRO) to analyze the current status and the future trend. MATERIALS AND METHODS: We searched the database of SCIE for the period from 1981 to 2011 at the Web of Knowledge site. Articles, reviews or proceedings written by KOSRO members as the first or corresponding authors were included. Search terms were the following combination of subject headings: therapeut radiol, radiat oncol, Korea. For National Cancer Center, combined search terms such as natl canc ctr, Korea and the names of faculties were applied. RESULTS: The total number of SCIE papers was 547. Numbers of the published papers in 1995, 2000, 2005, and 2010, were increased continuously, which was 2, 14, 40, and 83, respectively. The average impact factor was 2.9. The papers were published at the 134 different journals. The proportion of "International Journal of Radiation Oncology Biology Physics" was 23.4% of all the papers. The number and proportions of papers by subject categories were 87 (15.9%) in biology, 73 (13.3%) in physics and 387 (70.6%) in clinics. The papers of the top five institutions, based on the number of published papers, occupied 66.3%. CONCLUSION: The number of SCIE papers is increasing rapidly in the field of radiation oncology in Korea. To improve the quality of papers, multi-institutional retrospective or prospective randomized studies should be done for the common cancers in Korea.
Biology ; Korea ; Publications ; Radiation Oncology

Cutis laxa is a rarely discussed entity which manifests itself primarily as loose redundant skin and may be accompanied by internal anomalies. Localized cutis laxa is involved to the ear lobules, eyelids an lips in 34 years old male was described. Diagnosis of localized cutis laxa was established by clinical characteristic manifestations and histopathological studies.
Adult ; Cutis Laxa* ; Diagnosis ; Ear ; Eyelids ; Humans ; Lip ; Male ; Skin

A case of Peutz-Jeghers syndrome was experienced with melanin pigmentation in the oral cavity and lips associated small intestine polyposis. Diagnosis of Peutz-Jeghers syndrome was established by clinical characteristics of skin and X-ray studies of gastrointestinal tracts.
Diagnosis ; Gastrointestinal Tract ; Intestine, Small ; Lip ; Melanins ; Mouth ; Peutz-Jeghers Syndrome* ; Pigmentation ; Skin

The chronic paranasal sinusitis are caused by various orign such as dental, general and anatomic problem. Among them, the odontogenic maxillary sinusitis which concerned by cral & maxillofacial surgeon have been treated by medicine, conservative treatment such as endodontic treatment, and Caldwell-Luc operation. But, New technique, so called Functional Endoscopic Sinus Surgery, have recently been performed in the ENT dept. This technique have the mechanism that widening maxillary ostium through removal of involved nasal mucosa and adjacent tissue accelerates adequate drainage and regeneration of normal mucosa and have merits such as minimum morbidity and complication. So, we would report one case, 22 years old female, of 3 patents who were diagnosed as odontogenic maxillary sinusitis and treated by Functional Endoscopic Sinus Surgery and Apicoectomy, and had good results.
Apicoectomy ; Drainage ; Female ; Humans ; Maxillary Sinus* ; Maxillary Sinusitis* ; Mucous Membrane ; Nasal Mucosa ; Regeneration ; Sinusitis ; Young Adult

No Abstract Available.
Glaucoma* ; Ligation* ; Silicones*

BACKGROUND: The differential diagnosis of clonal and reactive thrombocytosis is clinically relevant because course and treatment are different between them. Several clinical assessments and laboratory tests (degree of such as splenomegaly, duration and degree of thrombocytosis, bone marrow study, cytogenetic study, and platelet function test) are less discriminative, invasive and not commonly available. Therefore, a well discriminative, simple and convenient diagnositic assay is needed. Recently animal experiments demonstrated that recombinant IL-6 administration increased platelets counts by stimulating megakaryocyte maturation and increased hepatic CRP synthesis. So, in this study, we evaluated the usefulness of measurements of IL-6 and CRP levels to distinguish reactive thrombocytosis from clonal thrombocytosis. METHODS: Included in this study were 88 patients with marked thromobocytosis (>600 x10(9)/L) at Asan Medical Center between September, 1995 and March, 1996. The cause of thrombocytosis was determined by reviewing the medical histories. Sixteen patients had clonal thrombocytosis and 72 patients had reactive thrombocytosis. IL-6 was measured by ELISA (Quantikine(TM), R&D system, Inc., Minneapolis, USA) and CRP was assayed by rate immunonephelometry (Array 360 system, Beckman Instruments Inc., USA). RESULTS: The patients with reactive thrombocytosis had significantly higher plasma levels of IL-6 and CRP than patients with clonal thrombocytosis (p<0.01, p<0.001). In 98.6% (71/72) of the patients with reactive thromobocytosis, levels of either IL-6 or CRP were elevated, and 43.8% (7/16) of the patients with clonal thrombocytosis had both IL-6 and CRP in normal range. Of 9 patients with clonal thrombocytosis (56.2%) whose levels of either IL-6 or CRP increased, 7 patients had concomitant acute phase reaction such as infection or post operative status. There was significant correlation between IL-6 and CRP levels (r2=0.4, p<0.0001). CONCLUSION: Elevated levels of either IL-6 or CRP were consistent with reactive thrombocytosis and normal ranges of those suggested clonal thrombocytosis. So measurement of plasma IL-6 and CRP levels is a useful marker for differential diagnosis of clonal and reactive thrombocytosis. For the patients with clonal thrombocytosis who had concomitant acute phase reaction, serial measurements are recommended.
Acute-Phase Reaction ; Animal Experimentation ; Blood Platelets ; Bone Marrow ; C-Reactive Protein* ; Chungcheongnam-do ; Cytogenetics ; Diagnosis, Differential* ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interleukin-6* ; Megakaryocytes ; Plasma* ; Reference Values ; Splenomegaly ; Thrombocytosis*

PURPOSE: To describe chronic rectal mucosal damage after pelvic radiotherapy (RT) for cervical cancer and correlate these findings with clinical symptoms and radiation dose. MATERIALS AND METHODS: Thirty-two patients who underwent pelvic RT were diagnosed with radiation-induced proctitis based on endoscopy findings. The median follow-up period was 35 months after external beam radiotherapy (EBRT) and intracavitary radiotherapy (ICR). The Vienna Rectoscopy Score (VRS) was used to describe the endoscopic findings and compared to the European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) morbidity score and the dosimetric parameters of RT (the ratio of rectal dose calculated at the rectal point [RP] to the prescribed dose, biologically effective dose [BED] at the RP in the ICR and EBRT plans, alpha/beta = 3). RESULTS: Rectal symptoms were noted in 28 patients (rectal bleeding in 21 patients, bowel habit changes in 6, mucosal stools in 1), and 4 patients had no symptoms. Endoscopic findings included telangiectasia in 18 patients, congested mucosa in 20, ulceration in 5, and stricture in 1. The RP ratio, BEDICR, BEDICR+EBRT was significantly associated with the VRS (RP ratio, median 76.5%; BEDICR, median 37.1 Gy3; BEDICR+EBRT, median 102.5 Gy3; p < 0.001). The VRS was significantly associated with the EORTC/RTOG score (p = 0.038). CONCLUSION: The most prevalent endoscopic findings of RT-induced proctitis were telangiectasia and congested mucosa. The VRS was significantly associated with the EORTC/RTOG score and RP radiation dose.
Constriction, Pathologic ; Endoscopy ; Estrogens, Conjugated (USP) ; Follow-Up Studies ; Hemorrhage ; Humans ; Mucous Membrane ; Proctitis ; Radiation Injuries ; Rectum ; Telangiectasis ; Ulcer ; Uterine Cervical Neoplasms

The Pumping technique generally has been known as a diagnostic method that predicts intracapsular status and selects required evaluation and treatment. But, in addition to this indication, when it is followed by Lavage and Manipulation technique, this may be used as therapeutic method that is effective on Closed Lock with limited mouth opening and pain. Therefore, we examined results of this technique abut Closed Lock and would like to report therapeutic effects of Lavage and Manipulation technique. We selected 40 patients of 200 patients diagnosed as Closed Lock over 53 months from SEP. 1991 to PEB. 1996, who were possible follow-up and performed by Lavage and Manipulation technique. Appraisal between pre-procedure and post-procedure was performed just after procedure, in 1 month and in 3 months, and therapeutic effects were divided by marked, useful, a little useful and ineffective. As a result, Lavage and Manipulation technique had remarkable increase of maximum mouth opening(>5mm) in 39 persons(98%) just after proceure, 36 persons(90%) in 1 month, and 39 persons(98%) in 3 months, and subsided pain completely just after procedure and had remarkable decrease of pain in 30 persons(75%) in 1 month, 32 persons(80%) in 3 months. So we concluded that the Lavage and Manipulation technique is effective therapy of Closed Lock which can be used with ease.
Follow-Up Studies ; Humans ; Mouth ; Temporomandibular Joint* ; Therapeutic Irrigation*