We describe an 18-year-old male with generalized pruritic, tense annular or polycyalic blistera on normal-appearing skin or erythematous bases. Histopathological fmdings of an iatact early blistering showed subepidermal blistering and papillary neutrophilic gnicroabscesses. A direct immunofluctescent study of a section from the skin adjacent to a lesioti revealed linear deposits of IgA at the dermoepidermal junction. There were no deposits of IgG, lgM, or C3. In 1.0M NaC1 eplit skin, IgA was found to be bound linearly on the epidermal roof. The patient respmded weIl to eteroid and dapsone therapy.
Adolescent ; Blister ; Dapsone ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Linear IgA Bullous Dermatosis* ; Male ; Neutrophils ; Skin ; Transcutaneous Electric Nerve Stimulation

No abstract available.

In glaucoma patients, optic nerve head analysis is very useful in early detection and progression during follow-up. Among optic nerve head analysis methods, the confocal laser tomographic scanner(Heidelberg Retina Tomograph: HRT) is actively studied for accurate and highly reproducible analysis.We analyzed the optic nerve head of 62 normal eyes(male 40 eyes, female 22 eyes) in third decade of Korean with HRT, and calculated the mean value of each parameters in HRT and evaluated the difference between men and women. We also studied the distribution fo the value of each parameter in normal third decade of Korean. In addition, for the parameters of Rim/Disc area ratio, we calculated the mean value in 6 divisions of optic nerve head.The mean value of Disc area was 2.039mm3, Cup area 0.593mm3, rim area 1.716mm3 and Cup/Disc area ratio 0.237. Rim volume, Maximal cup depth, Height variation contour, Mean retinal nerve fiber layer thickness, and Retinal nerve fiber layer cross sectional area were statistically different between men and women. For Rim/Disc area ratio, the maximal value was noted in nasal inferior(0.873) region, and the minimal value was in temporal(0.579) region. There was no statistically difference between men and women in Rim/Disc area ratio.
Female ; Follow-Up Studies ; Glaucoma ; Humans ; Male ; Nerve Fibers ; Optic Disk* ; Optic Nerve* ; Retina ; Retinaldehyde

No Abstract Available.
Melanoma* ; Stomach*

We herein report three cases of pararneatal urethral cyst, which developed on the male urethral meatus. These cysts occurred since birth or childhood, and did not interfere with urinary of sexual function. Histologically, these cysts were lined by pseudostratified columnar epithelium with variable thickness. No recurrence was evident after simple excision.
Epithelium ; Humans ; Male ; Parturition ; Recurrence

No abstract available.

No Abstract Available.
Cytokines* ; Perforin* ; Shwartzman Phenomenon* ; Vibrio vulnificus* ; Vibrio*

Orthodontists want why the patients want orthodontic treatment. Demand and need for orthodontics is very important factors of cooperation and management. Chief complaint would be different according to the race and culture. Our results show that in the control group, Korean female adolescents[chief complaint is cowding(30.6%), spacing(26.5%), upper anterior protrusion(18.4%), anterior cross bite(8.2%) in order. Korean female adolescents considered anterior cross bite is more nonacceptable than spacing and anterior protrusion. The purpose of orthodontics seemed to enhance esthetic, dental health, and to improve oral function.
Adolescent ; Continental Population Groups ; Esthetics, Dental ; Female ; Humans ; Malocclusion* ; Orthodontics*

Garlic is a well known edible plant and has been used as a herbal medicine. It is a member of Liliaceae which contains allylpropyldisulfide, diallyldisulfide and allicin which can induce allergic contact dermatitis or primary irritant dermatitis applied topically. A 53-year-old female patient was presented with vesicles, crust and erythema on her left buttock. She applied crushed raw garlic on the lesion site for the treatment of residual skin lesion following herpes zoster.
Buttocks ; Dermatitis, Allergic Contact ; Dermatitis, Contact* ; Dermatitis, Irritant ; Erythema ; Female ; Garlic* ; Herbal Medicine ; Herpes Zoster ; Humans ; Liliaceae ; Middle Aged ; Plants, Edible ; Skin

BACKGROUND: The proto-oncogene c-met encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF), which is a pleiotropic cytokine that controls growth, survival, motility, invasive migration, and differentiation of epithelial cells. Like several other epithelial neoplasms, thyroid carcinomas have been found to overexpress the c-met oncogene. We presently examine the expression of c-met protein in thyroid tumors and the correlation of c-met protein expression with prognostic factors in thyroid cancers. METHOD: We have examined the expression of the c-met oncogene in 62 paraffin-embedded thyroid cancer specimens (54 papillary carcinomas, 5 follicular carcinomas, 2 medullary carcinomas, and 1 anaplastic carcinoma), 20 benign tumors and 20 normal tissues using immunohistochemistry. We measured both the proportion and the intensity of stained cells and then calculated the staining index by multiplying the proportion and intensity scores. The staining index were categorized to be negative/low (staining index < or = 5) or high(staining index >5). The most important prognostic factors were age (over 45), tumor size (over 1.5 cm), lymph node metastasis, capsular invasion, vascular invasion and peripheral metastasis. RESULT: 1) The rate of expression of the c-met oncogene were 100%, 100% and 60% in thyroid cancer, benign tumors and normal thyroid tissue respectively. The expression of the c-met oncogene was restricted to the membrane. 2) The staining index of normal tissue, benign tumors and thyroid carcinomas was 1.8, 4.3 and 5.8 respectively. In malignancies, the staining index of papillary carcinoma was 5.7, follicular carcinoma 5.4, medullary carcinoma 7.5, and anaplastic cancer 9. 3) A high expression of c-met was not correlated with prognostic factors in papillary, follicular carcinomas or medullay carcinomas. CONCLUSION: The c-met oncogene might not play a role in the pathogenesis of thyroid neoplasia. There was no correlation between the high expression rate of the c-met oncogene and prognostic factors in papillary and follicular carcinomas.
Carcinoma, Medullary ; Carcinoma, Papillary ; Epithelial Cells ; Hepatocyte Growth Factor ; Immunohistochemistry ; Lymph Nodes ; Membranes ; Neoplasm Metastasis ; Neoplasms, Glandular and Epithelial ; Oncogenes* ; Protein-Tyrosine Kinases ; Proto-Oncogenes ; Thyroid Gland* ; Thyroid Neoplasms