Dermatofibrosarcoma protuberans (DFSP) is a rare, distinctive cutaneous tumor, which consists of spindle shaped ceils arranged in densely packed interlacing bundles with the storiform or cartwheel pattern. Histologically, it resembles deep growing dermatofibroma, nodular fasciitis, neurofibroma and neural sheath tumors. DFSP is one of t.he connective tissue tumors which is difficult. to diagnose histologically as well as clinically. Recently, the immunochemical staining with a monoclonal antibody to CD34 is reported to give assistance in the clear differential diagnosis of DFSP from other fibrous or neural tumors. Herein, three cases of DFSP were stained by immunohistochemical staining with S-100 protein, vimentin, factor VIII and anti-CD34 antibody in order to assess the use of anti-CD34 in the differential diagnosis of DFSP.
Connective Tissue ; Dermatofibrosarcoma* ; Diagnosis, Differential ; Factor VIII ; Fasciitis ; Histiocytoma, Benign Fibrous ; Neurofibroma ; S100 Proteins ; Vimentin

Angiolymphoid hyperplasia with eosinophilia (Kimura`s disease) is a pathologic term, given to a lesion starting usually as a papule or a cluster of papules in the skin of the head, neck and elsewhere of adults. This lesion is as extraordinary in its behavior as it is in its histology. Histologically, the characteristic features include abnormal vascular proliferations due to the growth of atypical histiocytic cells as the common dominator for all of these lesions. These lesions were apparently benign and can usually cured by surgical excision, adrenocorticosteroids and irradiation. Spontaneous remission also occurs. Herein, We report a case of this rare entity involving scrotum, reviewing the similar descriptions in western literature under various different headings.
Adult ; Angiolymphoid Hyperplasia with Eosinophilia ; Head ; Humans ; Hyperplasia* ; Neck ; Remission, Spontaneous ; Scrotum ; Skin

Currently, the cell surface antigen A,B,O(H) is thought to be an important indicator of malignant potential in bladder carcinoma. Herein, we performed SRCA test in 54 bladder carcinoma for detection of such an isoantigen, comparing the SRCA result to its tumor grade and stage. Also, various significances including the clinical application of SRCA test for the management of the bladder carcinoma were discussed. The results were as follows: 1. Of 54 patients, 34 patients were low stage(0-A) and low grade(1-2). 2. There is a significant correlation between tumor grade and SRCA test: Of 38 patients with low grade. 19 patients were SRCA positive, but of 16 patients with high grade. all were SRCA negative. 3. There is a significant correlation between tumor stage and SRCA test: Of 36 patients with low stage, 18 patients were SRCA positive, but of 18 patients with high stage(above B1), only one patient was SRCA positive. 4. There is a high possibility of false-negative results in detecting O(H) isoantigen: Of 36 patients with low stage, 6 patients were blood group 0 who were all SRCA negative. but 30 patients with other blood groups showed variable SRCA results. 5. There is a considerable correlation between tumor recurrence and SRCA result: Of 20 patients who were followed more than one year after initial TUR, 8 patients were SRCA positive, of these 4 patients were recurred, but 9 patients of 12 patients with SRCA negative were recurred.
Antigens, Surface* ; Blood Group Antigens ; Humans ; Isoantigens ; Recurrence ; Urinary Bladder*

During recent years, many investigators studied to confirm the pathogenesis of atopic dermatitis but it remains obscure. However, two major proposals, the B-padrenergic blockade hypothesis of Szentivanyi and the immunological hypothesis, have been advanced. The significant role of IgE in the pathogenesis of atopic dermatitis was considered since the discovery of elevated IgE levels in atopic dermatitis in 1969. However, recent various reports have indicated the existence of immune defects not only in humoral but also in cellular immune status of patients with atopic dermatitis. This study was undertaken to assess the humoral and cellular immune status of patients with atopic dermatitis using in vitro immune parametera The relationship between the humoral and cellular immune status of atopic subjects and the severity of disease was examined reapectively. The effect of the corticosteroid administration on the serum IgE levels of the patients with atopic dermatitis was followed. Eighty-three patients with atopic dermatitis, diagnosed and treated at the Department of Dermatology, Soon Chun Hyang University Hospital from October, 1988 to September, 1981 and twenty-one normal healthy subjects were included in this: study. Serum lgE levels were measured by Phadebas IgE (paper radio-immunosorbent technique) and peripheral blood T-lymphocytes (early and total) wer enumerated by the E-rosette technique.
Dermatitis, Atopic* ; Dermatology ; Humans ; Immunoglobulin E* ; Research Personnel ; T-Lymphocytes*

We report a case of epidermolysis bullosa acqumta with characteristic clinical features, subepidermal vesicles in histopathology, and deposits of IgG in basement membrane zone at routine direct immunofluorescent test. 1M NaCl-treated immunofluorescent test was performed in order to correctly diagnose our case. In this method, linear immunofluorescent deposits of IgG were found only at the dermal part of separation induced by 1M NaC1 treatment to skin specimen.
Basement Membrane ; Epidermolysis Bullosa Acquisita* ; Epidermolysis Bullosa* ; Immunoglobulin G ; Methods ; Skin

The epidermal nevus syndrome is a disorder characterized by epidermal nevi and associated neurologic, skeletal, and other abnormalities. A 15-year-old female patient presented with extensive, bilateral systematized, verrucous plaques, involving the face, trunk, both extremities, and anogenital area. The onset of the lesions were at the age of 2 months. Abdominal CT showed the absence of the left kidney, teratoma of the right ovary and left ovarian cyst. This is a case of epidermal nevus syndrome, which was composed of extensive epidermal nevi, congenital solitary kidney, left ovarian cyst and right ovarian teratoma.
Adolescent ; Extremities ; Female ; Humans ; Kidney ; Nevus* ; Ovarian Cysts ; Ovary ; Teratoma ; Tomography, X-Ray Computed ; Urogenital Abnormalities*

BACKGROUND: The majority of Staphylococcus aureus strains isolated from atopic eczema skin produce toxins like enterotoxin B or toxic shock syndrome toxin-1(TSST-1) as a superantigen and these toxins may contribute to the exacerbation of this skin disease. OBJECTIVE: We designed this study in order to investigate the effect of toxic shock syndrome toxin-1 on IL-4, interleukin-10(IL-10), interleukin-12(IL-12) and IFN- r production by peripheral blood mononuclear cells from normal and atopic patients. METHODS: Peripheral mononuclear cells obtained from ten patients with severe atopic dermatitis and ten healthy volunteers were stimulated with TSST-1 and cultured for 4 days. The amount of IL-4, IL-10, IL-12 and IFN- r in the culture supernatants were determined by a solid-phase enzyme- linked immunosorbant assay. RESULTS: l. After stimulation with TSST-1, IL-4, IL-10, IL-12 and INF- r, production of peripheral mononuclear cells from both atopic patients and healthy volunteers were increased. 2. After stimulation with TSST-1, the amount of IFN- r in the culture supernatants was significantly greater in the healthy controls than in the atopic patients. 3. After stimulation with TSST-1, the amount of IL-10 in the culture supernatants was significantly greater in the healthy controls than in the atopic patients. CONCLUSION: This data indicates that TSST-1 induces Thl-type and Th2-type cytokines associated with parallel Thl and Th2 stimulation in atopic patients and healthy donors. In addition, peripheral mononuclear cells from atopic patients have a diminished capacity to synthesize IFN- r and IL-10 in vitro in response to stimulation with TSST-1. Our results suggest that TSST-1 is not considered as a really important aggravating factor in atopic dermatitis.
Cytokines ; Dermatitis, Atopic ; Enterotoxins ; Healthy Volunteers ; Humans ; Interferon-gamma* ; Interleukin-10 ; Interleukin-12 ; Interleukin-4 ; Interleukins* ; Shock, Septic* ; Skin ; Skin Diseases ; Staphylococcus aureus ; Tissue Donors*

Periodontal supporting tissue goes through destruction by chronic inflammatory periodontal disease as two aspect. One is qualitive aspect such as alteration of periodontium, the other is quantitative aspect such as alveolar bone loss. According to many authors, PDL is responsible for biting force, and there are two means for measuring PDL's function - mobility test and biting force test. This study was conducted to compare the biting force with remaining bone level, that is, quantitative aspect of periodontium, in anterior and premolar teeth at periodontal maintenance phase. 17 patients on periodontal maintenance phase during 6 months at minimum were selected for this study. For the same condition, 4 anterior, canine, premolar teeth were tested by MPM-3000 bite-force register at the same time(a.m.10-12), the same position, the same posture, by the same examiner. Patients of TMD, ill-fitting prosthesis, general disease, malocclusion and the teeth of TFO, absence of opposing teeth, malposition were excluded. Remaining bone level was measured on the panorama X-ray film through 5 level from 1mm below CEJ to root apex. Teeth were examined twice, and bigger one was selected. If the values showed large difference, examinatin was re-done and the mean was selected. The results were as follows ; 1. In the 4 anterior group, as the remaining bone is decreased, the average of maximal biting force is decreased. Especially, at 3/5 bone level, maximal biting force is decreased significantly(p<0.01). 2. In the canine group, as the remaining bone is decreased, the average of maximal biting force is decreased. Especially, at 2/5 bone level, maximal biting force is decreased significantly(p<0.01). 3. In the premolar group, as the remaining bone is decreased, the average of maximal biting force is decreased. Especially, at 3/5 bone level, maximal biting force is decreased significantly(p<0.05). From the results of this study, clinicians could utilize these efficiently when they have to determine the proper restorative materials, time for tooth extraction. treatment plan, prognosis.
Alveolar Bone Loss ; Bicuspid* ; Bite Force* ; Humans ; Malocclusion ; Periodontal Diseases ; Periodontium ; Posture ; Prognosis ; Prostheses and Implants ; Tooth Cervix ; Tooth Extraction ; Tooth* ; X-Ray Film

Currently, uric acid disorders, especially including hyperuricosuria, are thought to be important in the formation Of idiopathic calcium urolithiasis. Herein, we estimated the serum concentration and urinary excretion of uric acid in I22 stone-formers, comparing to those in 56 controls. Also, various theories about the pathogenesis of uric acid disorder and stone formation were discussed. The results were as follows: 1. Serum uric acid levels of stone-formers were significantly higher than those of controls, in total and female, but, not in male. 2. Urinary uric acid levels of stone-formers were significantly higher than those of controls in total, male and female. 3. Hyperuricemia was significantly more frequent for stone-formers in total, male and female. 4. Hyperuricosuria was significantly more frequent for stone-formers in total, but, not significantly more frequent for stone-formers in male and female. 5. The incidence of stone-formers, in whom hyperuricemia and hyperuricosuria were not present at the sometime, was significantly less than that Of controls. These results suggest the possibility that uric acid disorder may play some roles in the genesis of urinary stone.
Calcium ; Female ; Humans ; Hyperuricemia ; Incidence ; Male ; Uric Acid* ; Urinary Calculi* ; Urolithiasis

BACKGROUND: Substrates play an important role in the effectiveness of the indirect immunofluro-rescence test. The monkey eaophagus has been known to be a more reliable and reproducible substrate than any other animal substrates for detecting pemphigus vulgaris autoantibodies, but it is quite difficult to get the monkey esophagus in Korea, therefore, we tried to find other substrates which could be substituted for it. OBJECTIVE: We studied to select the substrate which can be the most sensitive, to compare the immunofluorescent sensitivity of various animal substrates and fores,cins for detection of pemphigus autoantibodies, and finally to evaluate the effectiveness of cultured hunan keratinocytes as a substrate for indirect immunofluorescerice. METHOD: With foreskin, guinea pigs, cats, rats, dogs, rabbits and cultured human keratinocytes as substrates, an indirect imrnunofluorescence test was performed to detect pemphigus vulgaris autoantibodies in seven sera from the active patients before treatment and diluted serially from 1:10 to 1:1280 RESULT: We could detect pernphigus autoantibodies in all animal subtrates used in this study except rats and obtain good immunofluorescent results with foreskin, guinea pigs, and cultured human keratinocytes. The results were moderate with dogs, cats, rabbits, and poor with rats. CONCLUSION: We confirm thut cultured human keratinocytes can be a good effective substrate. According to effectiveness, subtrates can be divided into three groups. Foreskin, guinea pigs, and cultured human keratinocytes are included in the good effective substrate group, dogs, cats, and rabbits in the modeate group and rats in the poor substrate group, but we can not find any superiority of substrates within each groups.
Animals ; Autoantibodies* ; Cats ; Dogs ; Esophagus ; Fluorescent Antibody Technique, Indirect* ; Foreskin ; Guinea Pigs ; Haplorhini ; Humans ; Keratinocytes ; Korea ; Pemphigus* ; Rabbits ; Rats