Peripheral longitudinal tears of the menisci in nine patients(eight men and one woman) were repaired by arthroscopic techniques from December 1985 to November 1986. Six lateral and three medial menisci were repaired. The results of the repairs were classified by Tapper and Hoover scale as excellent 2, good 4, fair 2 and poor 1. The aversge durstion of follow up was 17.6 months(range : twelve to twenty-four months). One patient had a rerupture and two patients had hemarthrosis. The repairs of peripheral meniscal tears hsve been shown to be an effective and successful procedure. Arthroscopic instruments and techniques have been improved to allow for the repair of some of these tears.
Arthroscopes ; Follow-Up Studies ; Hemarthrosis ; Humans ; Knee ; Male ; Menisci, Tibial ; Tears

Tuberous sclerosis is a rare heredofamilial disease involving multiple organs, classically associated with the clinical triad of adenoma sebaceum, epilepsy, and mental retardation. We have recently experienced a case of tuberous sclerosis, 18-year-old male patient, who had typical adenoma sebaceum and generalized epileptic seizure. Plain skull film showed multiple calcified paraventricular subependymal nodules and brain CT scan disclosed characteristic calcified tubers adjacent to the frontal horn and body of the lateral ventricle.
Adolescent ; Animals ; Brain ; Epilepsy ; Horns ; Humans ; Intellectual Disability ; Lateral Ventricles ; Male ; Skull ; Tomography, X-Ray Computed ; Tuberous Sclerosis*

No abstract available.
Neurocutaneous Syndromes*

No abstract available.
Neurocutaneous Syndromes*

Authors report the clinical study on the usefulness of thyrotropin-releasing hormone tartrate(TRH-T) in the treatment of mild disturbance of consciousness. 20 patients suffering head trauma, subarachnoid hemorrhage, and intracerebral hemorrhage were given TRH-T intravenously for ten days. TRH-T was effective for the patients in whom the consciousness disturbance was mild, the duration in fixed consciousness level was short, and the brain was not distorted on CT scan. These features were most prominent in patients with subarachnoid hemorrhage. Three was no significant side effect, and TRH-T turned out to be safe.
Brain ; Cerebral Hemorrhage ; Consciousness* ; Craniocerebral Trauma ; Humans ; Subarachnoid Hemorrhage ; Thyrotropin-Releasing Hormone ; Tomography, X-Ray Computed

No abstract available.
Fistula ; Neck* ; Salivary Glands*

Several cases of familial occurrence of gliomas have been reported, but little has been known on the importance of genetic factors, which indeed remains controversial. In establishing the genetic basis for cancer susceptibility, the evaluation of a single family is perhaps the most satisfactory and meaningful approach. We report a family in which the 47-year-old father had glioblastoma in cerebellar vermis and his 14-year-old daughter developed pilocytic astrocytoma in cerebellar hemisphere. Karyotypic analysis of this family showed no abnormal findings in chromosomes.
Adolescent ; Astrocytoma ; Fathers ; Glioblastoma ; Glioma* ; Humans ; Karyotype ; Middle Aged ; Nuclear Family

PURPOSE: This study evaluated mid-term clinical and radiological results of autologous bone marrow transplantation (BMT) for early stage osteonecrosis of the femoral head (ONFH) and analyzed prognostic factors. MATERIALS AND METHODS: From November 2003 to April 2008, 101 hips of 93 patients with early stage ONFH who underwent autologous BMT were followed for at least five years. For clinical results, preoperative and postoperative Harris hip scores (HHS) were evaluated and survival rate was obtained at the point of performing total hip arthroplasty or femoral head collapse progression. Radiologic results were assessed by changes in necrosis size on magnetic resonance imaging performed preoperative and postoperatively. For evaluation of prognostic factors, survival rate was analyzed according to age, gender, etiology, stage, necrosis size, and location. RESULTS: Averaged HHS at latest follow up showed no significant change in comparison with preoperative HHS. Of 101 hips, 35 hips required arthroplasty and six hips were running head collapse. Groups with use of steroid, lateral location of necrosis, large size of necrosis, or large necrotic angles showed lower survival rate. However, age, gender, and stage had no effect. CONCLUSION: In early days, autologous BMT for early ONFH can be considered as a treatment for improvement of clinical features and delay of radiologic progress. However, after some years, there was no effect compared with the natural course of ONFH.
Arthroplasty ; Arthroplasty, Replacement, Hip ; Bone Marrow Transplantation* ; Follow-Up Studies ; Head* ; Hip ; Humans ; Magnetic Resonance Imaging ; Necrosis ; Osteonecrosis* ; Risk Factors ; Running ; Survival Rate

The authors reviewed twenty four patients with internal carotid-posterior communicating artery aneurysms with oculomotor palsy from 1976 to 1984. The incidence of third nerve palsy in the posterior communicating artery aneurysms was 37.5%(24 out of 64). The occurrence of the third nerve palsy without subarachnoid hemorrhage was 20.8%(5 out of 24). The initial degree of third nerve involvement seems to parallel the degree of recovery. Direct clipping of the aneurysm showed far better results than those of carotid ligation. The average duration of neurological recovery was 4.9 month after treatment. The order of third nerve function recovery was as follows:ptosis, pupil, medial gaze, and upward and downward gaze.
Aneurysm ; Arteries ; Humans ; Incidence ; Intracranial Aneurysm* ; Ligation ; Oculomotor Nerve Diseases* ; Oculomotor Nerve* ; Paralysis ; Pupil ; Recovery of Function ; Subarachnoid Hemorrhage

Guanine aminohydrolase(GAH;EC 3. 5. 4. 3.) was partially purified 122-fold from rat cerebrum to a specific activity of 7.22 in its per mg protein with a recovery of 7.47% by fractionation with ammonium sulfate, chromatography on DEAE-cellulose and hydroxyapatite, gel filtration on Sephadex G-200, and isoelectric focusing(pH4-6). The molecular weight of partially purified rat cerebral guanine aminohydrolase was estimated to be 110,000. But, in the cerebral cytosol, a rather higher molecular weight form of the enzyme was identified. The activity of the higher molecular weight form of guanine aminohydrolase was increased by dialyzing the cytosol, and it was converted into the lower molecular weight form(M.W.110,000) by addition of 2-mercaptoethanol. The reaction velocity of partially purified guanine aminohydrolase of rat cerebrum disclosed a hyperbolic curve, with its KM being 6.0uM at pH 8.0. The preparation showed high substrate specificity:among the purine nucleotides, nucleosides and bases with amino group, only guanosine and guanine were deaminated by the enzyme, and the reaction rate of the enzyme displayed by guanosine was less than 10% of that by guanine. When observed under the equimolar concentration of the substrate, hypoxanthine as well as inosine inhibited the activity of the rat cerebral guanine aminohydrolase by 9.4 and 7.8%, respectively, while 5-aminoimidazole-4-carboxamide inhibited the activity of it by 38%. The activity was inhibited by p-hydroxymercuric benzoate as well. Complete loss of its activity was observed after 30 minutes incubation at 60 degrees C, suggesting the preparation was heat labile.
Ammonium Sulfate ; Animals ; Benzoates ; Cerebrum* ; Chromatography ; Chromatography, Gel ; Cytosol ; DEAE-Cellulose ; Durapatite ; Filtration ; Guanine Deaminase* ; Guanine* ; Guanosine ; Hot Temperature ; Hydrogen-Ion Concentration ; Hypoxanthine ; Inosine ; Mercaptoethanol ; Molecular Weight ; Nucleosides ; Purine Nucleotides ; Rats* ; Xanthine Oxidase