1.A study of altered IL-6 and IL-10 expression in peritoneal fluid of endometriosis patients.
Kyung Suk LEE ; Jeong Bae KANG ; Hong Bae KIM ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1999;42(11):2558-2563
OBJECTIVE: Endometriosis is a disease affecting a large population of women all over the world. A local sterile inflammation occurs in the peritonel cavity of patients with endometriosis. It suggests that immunological events play a major role in the pathogenesis of endometriosis. We have studied the levels of serveral T cell and monocyte derived cytokines, especially IL-6 (promoter of immune response) and IL-10 (inhibitor of immune response), in the peritoneal fluid of patients with endometriosis to characterize the change of immune response that occurs at the site of endometriosis. Method: This study was performed in Hallym university hospital from October, 1997 to October 1998 and enrolled 29 women with gross or microscopic findings of minimal to severe endometriosis in case group, and 28 women without visual evidence of pelvic endometriosis and with benign gynecologic disease in control group. IL-6 and IL-10 levels in the peritoneal fluid were determined using commercial ELISA and compared between endometriosis and controls and between fertile and infertile women with endometriosis and according to the revised American Fertility Society classification. RESULT: IL-6 was higher and IL-10 was lower in the peritoneal fluid of endometriosis group than of control group. Cyclic variations in the IL-6 concentrations were seen in endometriosis group : the concentrations in the secretory phase were significantly higher than those in the proliferative phase. In endometriosis group, IL-6 concentrations of infertile women were higher than fertile women. Both IL-6 and IL-10 in the peritoneal fluid of endomtriosis group did not show significant correlation according to r-AFS stages. CONCLUSION: Increased IL-6 and decreased IL-10 levels in the peritoneal fluid may be related to infertility and pathogenesis in the endometriosis, suggesting that partially contribute to the disturbed immune regulation observed in endometriosis.
Ascitic Fluid*
;
Classification
;
Cytokines
;
Endometriosis*
;
Enzyme-Linked Immunosorbent Assay
;
Female
;
Fertility
;
Genital Diseases, Female
;
Humans
;
Infertility
;
Inflammation
;
Interleukin-10*
;
Interleukin-6*
;
Monocytes
2.Anal malignant melanoma: a case report and review of literatures.
Byeong Ryong SEOL ; Hyun Duk BAE ; Chae Won LEE
Journal of the Korean Surgical Society 1993;44(2):306-314
No abstract available.
Melanoma*
4.A Case of Shaken Baby Syndrome.
Jin CHOI ; Hyun Hee KIM ; Won Bae LEE
Journal of the Korean Pediatric Society 2000;43(6):851-855
Shaken baby syndrome refers to the group of nonaccidental injuries occuring in infants and children as a consequence of violent shaking. The characteristic injuries include subdural and subarachnoid hemorrhages, retinal hemorrhages, traction-typed metaphyseal fracture of long bone and fractures of the ribs. General physical findings may include bruising and burns, but sometimes no extracranial injuries are detected. Affected children are nearly always under 2 years of age or younger. Common symptoms include lethargy, irritability, seizures, increased or decreased muscle tone, poor feeding, impaired consciousness, vomiting and apnea. We experienced a case of shaken baby syndrome in a 3-month-old girl. Although the history of trauma(shaking) is little known, our findings of clinical and radiographic features corresponded to shaken baby syndrome. (J Korean Pediatr Soc 2000;43:851-855)
Apnea
;
Burns
;
Child
;
Consciousness
;
Female
;
Humans
;
Infant
;
Lethargy
;
Muscle Hypotonia
;
Retinal Hemorrhage
;
Ribs
;
Seizures
;
Shaken Baby Syndrome*
;
Subarachnoid Hemorrhage
;
Vomiting
5.Cell proliferatiion status, p53 protein and epidermal growth factor receptor(EGFR) expression-correlation with early recurrence in colorectal adenocarcinoma.
Eun Sook LEE ; Jeong Won BAE ; Cheung Woung WHANG
Journal of the Korean Society of Coloproctology 1993;9(4):309-322
No abstract available.
Adenocarcinoma*
;
Epidermal Growth Factor*
;
Recurrence*
6.An analysis of 923 facial bone fractures in 685 patients at the Korean army forces.
Bae Jeong CHO ; Un Kyo PARK ; Jong Won LEE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1992;19(6):1049-1059
No abstract available.
Facial Bones*
;
Humans
7.Conservative management of esophageal perforation: Clinical analysis of 14 cases.
Byung Woo BAE ; Hyung Ryul LEE ; Jong Won KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(8):633-637
No abstract available.
Esophageal Perforation*
8.Esophageal perforation: clinical analysis of 25 cases-.
Byung Woo BAE ; Hyung Ryul LEE ; Jong Won KIM
The Korean Journal of Critical Care Medicine 1992;7(2):155-164
No abstract available.
Esophageal Perforation*
9.Outcome Following Diffuse Brain Injury in Children.
Hack Gun BAE ; Jae Won DO ; Kyeong Seok LEE ; Il Gyu YUN ; In Soo LEE ; Won Kyong BAE
Journal of Korean Neurosurgical Society 1990;19(8-9):1136-1144
No abstract available.
Brain Injuries*
;
Child*
;
Glasgow Coma Scale
;
Humans
10.A Study of Altered Cell-Mediated Immunity in Peritoneal Fluid of Patients with Endometriosis.
Jeong Bae KANG ; Hyun Tae KIM ; Hong Bae KIM ; Keun Young LEE ; Sung Won KANG
Korean Journal of Obstetrics and Gynecology 1999;42(9):1965-1971
OBJECTIVE: Our purpose was to investigate the relationship between the levels of IL-6 and tumor necrosis factor-alpha in the peritoneal fluid(PF) of women with and without endometriosis and infertile women. Design: Prospective and case-control study. Setting: University hospital. Patients: Twenty-nine women with laparotomy or laparoscopic findings of minimal to severe endometriosis, and twenty-eight women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. Main Outcome Measures: PF IL-6 and tumor necrosis factor-alpha levels were determined using commercial ELISA. IL-6 and tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and with infertile and fertile women, and then also compared according the revised American Fertility Society classification. RESULTS: IL-6 and tumor necrosis factor-alpha concentrations were higher than in the PF of women with endometriosis than in matched normal controls. Cyclic variations in IL-6 concentrations were seen in PF from patients with endometriosis: the concentrations in the secretory phase were significantly higher than those in the proliferative phase. IL-6 concentrations were higher than in the PF among of infertile women than in fertile women. A significant correlation between PF IL-6 and tumor necrosis factor-alpha concentrations and endometriosis stage III and IV was noted. CONCLUSIONS: Increased PF levels of IL-6 and tumor necrosis factor-alpha in patients with endometriosis may be relate to endometriosis-associated infertility and to the pathogenesis of endometriosis suggesting that partially contribute to the disturbed immune regulation observed in patients with endometriosis.
Ascitic Fluid*
;
Case-Control Studies
;
Classification
;
Endometriosis*
;
Enzyme-Linked Immunosorbent Assay
;
Female
;
Fertility
;
Genital Diseases, Female
;
Humans
;
Immunity, Cellular*
;
Infertility
;
Interleukin-6
;
Laparotomy
;
Outcome Assessment (Health Care)
;
Prospective Studies
;
Tumor Necrosis Factor-alpha