1.Stent-assisted percutaneous angioplasty for extra-cranial carotid disease:experience at Singapore General Hospital.
Apoorva GOGNA ; Narayan LATH ; Hui Meng CHANG ; Bien Soo TAN ; Meng Cheong WONG ; Tian Hai KOH ; Soo Teik LIM ; Maung Myint HTOO ; Winston E H LIM
Annals of the Academy of Medicine, Singapore 2009;38(9):756-762
INTRODUCTIONThis study aims to analyse the results of carotid stenting in a tertiary referral centre in Singapore.
MATERIALS AND METHODSRetrospective analysis of all carotid artery stenting (CAS) cases in a single centre from March 1997 to December 2008 was performed. Sixty successful procedures were performed in 61 patients, with bilateral stenting in 1 patient, and 2 failed procedures. The majority were Chinese (78.7%) and males (77.0%), with a high proportion having hypertension (82.0%) and hypercholesterolaemia (78.7%). The majority (91.8%) of patients were high surgical risk candidates, primarily due to cardiac risk factors. Ten patients (16.4%) had prior neck irradiation for nasopharyngeal carcinoma, and 3 patients each (4.9%) had previous endarterectomy and contralateral occlusion. A distal embolic protection device was used in 71.7% of cases.
RESULTSTechnical success was 96.8%. The 30-day stroke and death rate was 13.8%, comparable to reported results for this high surgical risk population.
CONCLUSIONCAS is a technically feasible and a relatively safe alternative to endarterectomy to treat extracranial carotid stenosis, especially in patients who are inoperable or at high surgical risk.
Aged ; Aged, 80 and over ; Angioplasty ; methods ; Angioplasty, Balloon, Coronary ; methods ; Carotid Artery Diseases ; surgery ; Female ; Hospitals, General ; Humans ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Retrospective Studies ; Risk ; Singapore ; Stents
2.BNT162B2 COVID-19 mRNA vaccination did not promote substantial anti-syncytin-1 antibody production nor mRNA transfer to breast milk in an exploratory pilot study.
Citra N Z MATTAR ; Winston KOH ; Yiqi SEOW ; Shawn HOON ; Aparna VENKATESH ; Pradip DASHRAATH ; Li Min LIM ; Judith ONG ; Rachel LEE ; Nuryanti JOHANA ; Julie S L YEO ; David CHONG ; Lay Kok TAN ; Jerry K Y CHAN ; Mahesh CHOOLANI ; Paul Anantharajah TAMBYAH
Annals of the Academy of Medicine, Singapore 2022;51(5):309-312