1.Effects of acupuncture with different stimuli intensity on uterine contraction and expression of endocrine-related molecular receptor genes in rats with dysmenorrhea of cold coagulation pattern
Wing-Sze HSU ; Guo-Zhen ZHAO ; Bo JI ; Dan-Dan QI ; Meng-Wei GUO ; Xiao-Xuan REN ; Ya-Fang ZHAO ; Lu-Fen ZHANG ; Xiao-Hong LI ; Jiang ZHU ; He ZHANG ; Yan SONG ; Ya-Li LIU ; Ping ZHANG
Journal of Beijing University of Traditional Chinese Medicine 2015;(6):426-429,432
Objective To evaluate the effects of acupuncture with different stimulation intensity at Sanyinjiao (SP6) on uterine contraction and expression of endocrine-related molecular receptor gene in rats with dysmenorrhea of cold coagulation pattern and to explore whether there is association between“deqi ( qi arrival)” and stimulus intensity. Methods Diestrus female rats were randomly divided into 4 groups, in-cluding saline control group, model control group, deqi group ( with strong stimulus) and No deqi group ( with weak stimulus) . The levels of uterine contraction was recorded during 20 mins acupuncture treat-
ment. The expression of PGF2α mRNA was measured. Results Compared with the model control group, the uterine contraction wave number and uterine activity were significantly reduced in deqi group. The ex-pressions of PGF2αmRNA in both deqi and No deqi group were also reduced compared with model group. Conclusion Our finding indicates that using thick needles, deep insertion with hand-manipulation seems more effective and could achieve desired level of “deqi” in dysmenorrhea rats.
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