1.Epidemiological Aspects of Pertussis among Adults and Adolescents in a Korean Outpatient Setting: A Multicenter, PCR-Based Study.
Sunghoon PARK ; Sun Hwa LEE ; Ki Hyun SEO ; Kyeong Cheol SHIN ; Yong Bum PARK ; Myung Goo LEE ; Kwang Ha YOO ; Hui Jung KIM ; Jae Seuk PARK ; Jae Hwa CHO ; Yongchun KO ; Soo Keol LEE ; Ki Tae CHEON ; Do Il KIM ; Jun Wook HA ; Jae Myung LEE ; Ji Won SUHR ; Eui Hun JEONG ; Ki Suck JUNG
Journal of Korean Medical Science 2014;29(9):1232-1239
Epidemiological data of Bordetella pertussis infection among adolescents and adults are limited in Korea. Patients (> or = 11 yr of age) with a bothersome cough for less than 30 days were enrolled during a 1-yr period at 22 hospitals in Korea. Nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and for bacteriologic culture. In total, 490 patients were finally enrolled, and 34 (6.9%) patients tested positive for B. pertussis; cough duration (14.0 days [7.0-21.0 days]) and age distribution were diverse. The incidence was the highest in secondary referral hospitals, compared to primary care clinics or tertiary referral hospitals (24/226 [10.6%] vs. 3/88 [3.4%] vs. 7/176 [4.0%], P = 0.012), and the peak incidence was observed in February and August (15.8% and 15.9%), with no confirmed cases between March and June. In the multivariate analysis, post-tussive vomiting was significantly associated with pertussis (odds ratio, 2.508; 95% confidence interval, 1.146-5.486) and secondary referral hospital showed a borderline significance. In conclusion, using a PCR-based method, 6.9% of adolescent and adult patients with an acute cough illness had pertussis infection in an outpatient setting. However, hospital levels and seasonal trends must be taken into account to develop a better strategy for controlling pertussis.
Adolescent
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Adult
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Bordetella pertussis/*genetics
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Child
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DNA, Bacterial/*analysis
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Demography
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Female
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Humans
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Incidence
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Male
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Middle Aged
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Multivariate Analysis
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Odds Ratio
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*Polymerase Chain Reaction
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Republic of Korea/epidemiology
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Seasons
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Vomiting/etiology
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Whooping Cough/*epidemiology/microbiology/pathology
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Young Adult