We analyzed on chromosome of peripheral blood cell in comparison to hematological indices from 63 peoples between 1 and 31 years of irradiation exposure. The result showed that the aberrating rate was high in studied groups than control group significantly, especially, the rate of dysenteric choromosome. The hematological alteration is not clear yet.
Chromosome Aberrations ; Whole-Body Irradiation

The acute effects of variable dos rates to total body irradiation (TBI) were investigated with 600 cgy of single exposure in the mice as a preclinical model. Total 80 mice (ICR) were used. Twenty of which served as controls, receiving no irradiation. All irradiated mice showed a universal decline in their weight and white blood cell count. The degree of weight loss and leukopenia were similar at 3 different dos rate but slightly prominent with 15 cgy/minute group. The degree of recovery among the groups showed no dose rate dependence. Our results suggest that TBI with 15 cgy/minute may be applicable for clinical therapy with careful evaluation of patient's condition.
Animals ; Leukocyte Count ; Leukopenia ; Mice* ; Weight Loss ; Whole-Body Irradiation*

This study is designed to evaluate the effect of low-dose whole body irradiation (WBI) for treatment of myasthenia gravis(MG) and changes of immunological parameters. According to MG protocol of low dose WBI, eleven patients were selected and followed up for at least one year. Clinical status and immunological parameters were assessed at the time of pretreatment (baseline) and 1, 2, 3, 6, 12 months after initial dose irradiation. The improvement began five weeks after WBI and lasted for 12-month follow-up in 7 patients (good responders) Clinical improvement and immunological changes were more pronounced in good responders. So, it is suggested that low dose WBI may have the role in the treatment of the MG as an another therapeutic modality.
Follow-Up Studies ; Humans ; Myasthenia Gravis* ; Whole-Body Irradiation*

This paper describes the basic date measurements for total body irradiation with 6 Mv photon beam including compensators designs. The technique uses bilateral opposing field with tissue compensators for the head, neck, lungs, and legs from the hip to toes. In vivo dosimetry was carried out for determining absorbed dose at various regions in 7 patients using diode detectors (MULTIDOSE, Model 9310, MULTIDATA Co., USA). As a results, the dose uniformity of+/-3.5%(generally, within+/-10%) can be achieved with our total body irradiation technique.
Head ; Hip ; Humans ; Leg ; Lung ; Neck ; Toes ; Whole-Body Irradiation*

In total body irradiation (TBI) for leukemia, we have a two methode. One is a AP (anterior-posterior) method and the other is a Lateral methode. Our hospital used lateral methode. TBI must consider about body contour, because of homogeneous dose distribution. For compensation about irregular body contour, we use compensator. For TBI treatment, we must be considered, accurate manufacture of compensator and accurate calculation of dose. We developed the automatic program for TBI. This program accomplished for compensator design and dose calculation for irregular body. This program was developed for uses to use in a windows environment using the IDL language. In this program, it use energy data for each energy: TMR, output factor, inverse square law, spoiler, field size factor. This program reduces the error to happen due to the manual. As a development of program, we could decrease the time of treatment plan and care the patient accurately.
Compensation and Redress ; Humans ; Jurisprudence ; Leukemia ; Whole-Body Irradiation*

This paper describes the development of TBI technique about fractionated TBI and the relationship between irradiation dose rate and complication; IMRT for TBI and lung compensation technique.
Dose-Response Relationship, Radiation ; Humans ; Radiation Dosage ; Whole-Body Irradiation ; methods

The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10. The RT + placebo and control groups received same dose of soybean oil. After 24 weeks, laboratory and histopathologic findings were compared. The 2 RT groups showed significant increases in blood urea nitrogen (BUN) and creatinine levels and significant pathologic changes such as glomerulosclerosis and tubulointerstitial fibrosis. CoQ10 supplementation resulted in significant reductions of BUN and creatinine levels compared with the RT + placebo group (P < 0.001 and P = 0.038, respectively). CoQ10 treatment significantly attenuated glomerular and tubular changes of irradiated kidney in semiquantitative analysis (P < 0.001 for both). Administration of CoQ10 can alleviate the radiation-induced nephropathy.
Abdominal Cavity ; Animals ; Blood Urea Nitrogen ; Creatinine ; Fibrosis ; Humans ; Kidney ; Rats* ; Soybean Oil ; Whole-Body Irradiation

PURPOSE: Liquid beta emitter filled in angioplasty balloon could be used to perform endovascular balloon brachytherapy to prevent coronary artery restenosis. We investigated the dosimetry for Re-188-DTPA liquid-filled balloon and medical internal radiation dosimetry in case of balloon leakage. MATERIALS AND METHODS: We estimated radiation dose from an angioplasty balloon (20 mm lengfh, 3 mm diameter cylinder) to the adjacent vessel wall using Monte Carlo EGS4 code. We obtained time-activity curves of kidneys in normal dog and calculated Tmax, T1/2. Using MIRDOSE3 program, we estimated absorbed doses to the major organs (kidneys, bladder) and the whole body when we assumed that balloon leaked all the isotope contained. RESULTS: The radiation dose was 17.5 Gy at the balloon surface when we applied 3,700 MBq/ml of Re-188 for 100 seconds. Fifty percent of the energy deposited within 1 mm from the balloon surface. The estimated internal dose to the whole body was 0.005 mGy/MBq and 18.5 mGy for the spillage of 3,700 MBq of Re-188. CONCLUSION: We suggest that Re-188-DTPA can be used for endovascular balloon brachytherapy to inhibit coronary artery restenosis after angioplasty with tolerable whole body radiation dose in case of balloon rupture.
Angioplasty* ; Animals ; Brachytherapy* ; Coronary Vessels ; Dogs ; Kidney ; Radiometry ; Rupture ; Whole-Body Irradiation

Dermatomyositis is an inflammatory muscular disease of presumed autoimmune origin. Many possible interventions are available to treat patients with these conditions including corticosteroids, immunosuppressive drugs, plasnapheresis, and total body irradiation. But these therapies are not always effective, and they may be associated with certain serious side effects. Recently polyvalent. intravenous gammaglohulin(IVGG) has been tried with success in inflammatory myopathies after failure of traditional treatment We report a 8-year-old female patient with juvenile dermatomyositis who improved dramatically after alternative IVGG treatment due to side effects of steroid.
Adrenal Cortex Hormones ; Child ; Dermatomyositis* ; Female ; Humans ; Muscular Diseases ; Myositis ; Whole-Body Irradiation

We studied retrospectively on clinical assessment of treatment in myasthenic patients who visited on our department regularly since 1985. They were divided as a group based on therapeutic modalities such as a thymectomy, steroid therapy. Combined therapy(steroid and thymectomy), plasma exchange. And whole body irradiation. We evluated clinical effectiveness of these therapeutic modalities and come up with following conclusions. Alltherapeutic modalities showed effectiveness. In steroid therapy, thymectomy and the combined therapy. W needed at least 6-24 months for clinical improvement. In thymectomy, rognosis was depend on the number of germinal centers. In whole body irradiation. Effectiveness was shown at 5h week and continued to 6th to 12th months. We also noted that symptomatic improvement was correlated with decreased lymphocyte counts. The effect of plasma exchange was rapid but only short duration.
Germinal Center ; Humans ; Lymphocyte Count ; Myasthenia Gravis* ; Plasma Exchange ; Retrospective Studies ; Thymectomy ; Whole-Body Irradiation