No abstract available.
Korea*

PURPOSE: Prostaglandins(PGs) are known to produce a remarkably broad spectrum of effects that embraces practically every biological function, and has a particular physiological role in the central nervous system. Significant increases of PGs levels are seen in certain diseases, such as febrile infection, stroke, schizophrenia, and epilepsy. Prostaglandin is also increased in a response to rising body temperature, and prostaglandin E-2(PGE-2) in lumber cerebrospinal fluid is also increased in febrile convulsion. Intracerebroventricular injection of PGE produces a rise in body temperature and also antagonizes convulsions induced by pentylenetetrazole, penicillin, electric shock. Therefore we studied PGE-2 levels in cerebrospinal fluid of afebrile children, children with febrile convulsion, and febrile children without convulsion. METHODS: The subjects comprised 57 cases with febrile convulsion, 24 cases of afebrile diseases and 9 febrile children without convulsion. All patients were undergoing lumbar puncture and PGE-2 levels in CSF were determined by highly specific radio-immunoassay(Prostaglandin E2 [125I] assay system, Biotra Assays, Amersham Inc.). RESULTS: 1) The CSF PGE-2 levels were significantly higher in children with febrile convulsion(147.3+/-79.3pg/ml) than those in febrile children without convulsion(72.4+/-75.4pg/ml) and afebrile children(19.2+/-28.4pg/ml)(p<0.05). 2) There were no statistical significances of the CSF PGE-2 levels between age and fever in both groups. 3) The CSF PGE-2 levels within 4 hours(176.5+/-65.7pg/m1) after convulsions were significantly higher than those 4 hours after convulsion(93.3+/-74.9pg/ml). CONCLUSION: The CSF PGE-2 levels were significantly higher in children with febrile convulsion than those in febrile children without convulsion and those in afebrile child ran. The CSF PGE-2 levels within 4 hours after convulsion were significantly higher than those 4 hours after convulsion.
Body Temperature ; Central Nervous System ; Cerebrospinal Fluid* ; Child* ; Epilepsy ; Fever ; Humans ; Penicillins ; Pentylenetetrazole ; Prostaglandins E ; Prostaglandins I ; Schizophrenia ; Seizures ; Seizures, Febrile* ; Shock ; Spinal Puncture ; Stroke

No abstract available.
Breast Neoplasms* ; Breast* ; Female ; Humans

No abstract available.
Child* ; Epilepsy* ; Humans

Pseudoaneurysm is uncommon but a life threatening complication of chronic pancreatitis. Angiography has been the standard definitive imaging modality in the diagnosis of pseudoaneurysm. However, over the past 5 years duplux US and Dynamic CT have been proven to be valuable. The authors report a case of gastroduodenal pseudoaneurysm in chronic pancreatitis, which could be diagnosed by duplux US and Dynamic CT. Furthermore this case proved to be a pseudocyst which converted into a pseudoaneurysm by vessel rupture.
Aneurysm, False* ; Angiography ; Arteries* ; Diagnosis* ; Pancreatitis, Chronic* ; Rupture

No abstract available.
Bone Cysts* ; Methylprednisolone*

The congenital radio-ulnar synostosis is a rare malformation which often completely perevents pronation and supination of the forearm. Recently, this disese has no good result by treatment including various operative techniques. The authors have experience a case of the congenital radio-ulnar synostosis, which was corrected by modified Green method and satisfactory result was obtained.
Forearm ; Methods ; Pronation ; Supination ; Synostosis

Rigid posterior fixation of the atlas to the third and fourth cervical spine was achieved in a patient in whom axis pedicle fracture and dislocation of axis on the third cervical spine. Althouth there was no evidence of neurologic disorder, marked instability of axis on the third cervical spine should inevitably be fused in any procedures. An anatomically contoured loop was secured to the posterior arch of the atlas and the laminae of the third and the fourth cervical spine by sublaminar wirings. The technique has the advantage over bone graft, either alone or with cement, in that it affords rigid stabilization, allows early mobilization and some flexion movement of atlanto-occipital joint.
Atlanto-Occipital Joint ; Dislocations ; Early Ambulation ; Humans ; Nervous System Diseases ; Spine ; Spondylolisthesis ; Transplants

No abstract available.
Child* ; Humans

PURPOSE: Acute administration of non-selective serotonin (5-HT) reuptake inhibitor such as imipramine and selective 5-HT reuptake inhibitor, like fluoxetine leads, to an increase of extracellular 5-HT concentration in the brain. We sought to determine the average time spent asleep, the frequency of REM sleep, and the percent of REM and NREM sleep in the total sleep time in saline (sham-treated control) (n=6), imipramine (n=8), or fluoxetine (n=6)-treated animals. METHODS: Right and left cortical and hippocampal electrodes were placed in 10-15 day old Sprague-Dawley rats. The following day 2 hour video EEG recordings were done to monitor sleep induced by intraperitoneal injection of saline, imipramine (10mg/kg), or fluoxetine (10mg/kg) after getting a baseline EEG during 30 minutes. And data were analyzed using t-test. RESULTS: 1) Following intraperitoneal injection of saline, imipramine, or fluoxetine, there were no epileptiform features or changes in the EEG except for a difference in sleep cycling. 2) The percent of average time spent asleep was significantly greater for control (87.8%) and fluoxetine-treated animals (92%) compared to imipramine-treated animals (66.1 %) (p<0.005). 3) The average frequency of REM sleep was 11.2 in control, 0.1 in imipramine-treated animals, and 8.7 in fluoxetine-treated animals, respectively during the 2 hours. And the frequency of REM sleep was significantly less for imipramine-treated animals compared to control (p<0.002). 4) Control animals (41.2%) spent significantly less time in NREM sleep compared to imipramine (98.8%)- and fluoxetine (93%)-treated animals (p<0.0001) and significantly more time (58.8%) in REM sleep compared to both imipramine (1.2%)- and fluoxetine (7%) treated animals (p<0.0001). CONCLUSION: We confirmed that postnatal 10-15 day old rats spent more time in REM sleep than NREM sleep, and acute administration of imipramine or fluoxetine increased NREM sleep by decreasing the frequency and the duration of REM sleep by 5-HT reuptake inhibition in the brain.
Animals ; Brain ; Electrodes ; Electroencephalography ; Fluoxetine* ; Imipramine* ; Injections, Intraperitoneal ; Rats* ; Rats, Sprague-Dawley ; Serotonin ; Sleep, REM