1.A Case of Congenital Adrenal Agenesis.
Kyeong Wha LEE ; Hyung Jin CHOI ; Sang Man SHIN ; Sang Jhoo LEE ; Dong Wha LEE
Journal of the Korean Pediatric Society 1984;27(11):1118-1122
No abstract available.
2.Immunohistochemical Study on the Expression of Mutated p53 Protein and Bcl-2 Protein in Melanocytic Lesions of Skin.
Wha Jin LEE ; Joon Hyuk CHOI ; Won Hee CHOI
Korean Journal of Pathology 1997;31(2):112-120
To investigate the immunohistochemical expression of mutated p53 protein and bcl-2 protein in the cutaneous melanocytic lesion, 15 cases of compound nevus, 10 cases of congenital melanocytic nevus, 15 cases of primary malignant melanoma(4 cases less than 1.5 mm thick and 11 cases more than 1.5 mm thick), and 10 cases of metastatic malignant melanoma(7 cases in lymph node and 3 cases in soft tissue) were examined. All cases of compound nevi and of congenital melanocytic nevi showed no immunoreactivity for p53 protein. p53 protein overexpression was observed in 75%(3/4) wth primary malignant melanoma less than 1.5 mm thick, 81%(9/11) with primary malignant melanoma more than 1.5 mm thick, and 100%(10/10) with metastatic malignant melanoma. The difference in p53 protein overexpression was statistically significant between benign nevi and malignant melanoma(p<0.01). Bcl-2 protein expression was observed in 73%(11/15) with compound nevus, 70%(7/10) with congenital melanocytic nevus, 75% (3/4) in primary malignant melanoma less than 1.5 mm thick, 54%(6/11) with primary malignant melanoma more than 1.5 mm thick, and 40%(4/10) with metastatic malignant melanoma. These findings suggested that mutation of p53 gene may be an important mechanism in the development of malignant melanoma. Although bcl-2 protein was expressed in cutaneous melanocytic lesion, no correlation was found between p53 protein and bcl-2 protein expression in malignant melanoma.
Genes, p53
;
Lymph Nodes
;
Melanoma
;
Nevus
;
Nevus, Pigmented
;
Skin*
3.Immunohistochemical Study on the Expression of Mutated p53 Protein and Bcl-2 Protein in Melanocytic Lesions of Skin.
Wha Jin LEE ; Joon Hyuk CHOI ; Won Hee CHOI
Korean Journal of Pathology 1997;31(2):112-120
To investigate the immunohistochemical expression of mutated p53 protein and bcl-2 protein in the cutaneous melanocytic lesion, 15 cases of compound nevus, 10 cases of congenital melanocytic nevus, 15 cases of primary malignant melanoma(4 cases less than 1.5 mm thick and 11 cases more than 1.5 mm thick), and 10 cases of metastatic malignant melanoma(7 cases in lymph node and 3 cases in soft tissue) were examined. All cases of compound nevi and of congenital melanocytic nevi showed no immunoreactivity for p53 protein. p53 protein overexpression was observed in 75%(3/4) wth primary malignant melanoma less than 1.5 mm thick, 81%(9/11) with primary malignant melanoma more than 1.5 mm thick, and 100%(10/10) with metastatic malignant melanoma. The difference in p53 protein overexpression was statistically significant between benign nevi and malignant melanoma(p<0.01). Bcl-2 protein expression was observed in 73%(11/15) with compound nevus, 70%(7/10) with congenital melanocytic nevus, 75% (3/4) in primary malignant melanoma less than 1.5 mm thick, 54%(6/11) with primary malignant melanoma more than 1.5 mm thick, and 40%(4/10) with metastatic malignant melanoma. These findings suggested that mutation of p53 gene may be an important mechanism in the development of malignant melanoma. Although bcl-2 protein was expressed in cutaneous melanocytic lesion, no correlation was found between p53 protein and bcl-2 protein expression in malignant melanoma.
Genes, p53
;
Lymph Nodes
;
Melanoma
;
Nevus
;
Nevus, Pigmented
;
Skin*
4.Sebaceous Gland Tumor Arising in Cystic Teratoma of the Ovary: An unique form of monodermal teratoma.
Dae Joong KIM ; So Young JIN ; Dong Wha LEE
Korean Journal of Pathology 1992;26(1):82-87
Although cystic teratoma is the most common benign tumor of the ovary, the association of sebaceous gland tumor with cystic teratoma is rare. We have recently experienced a case of sebaceous gland tumor, arising in the cystic teratoma of the ovary in a 78-year-old Korean woman. Histologically, the tumor was characterized by an organoid lobular architectures of the sebaceous glands which are exculsively composed of germinative and mature sebaceous cells. Although it is difficult to come to a valid conclusion due to the presence of atypical mitosis and necrosis, this tumor was regarded as benign from the viewpoint of preserved organoid structures, and absence of capsular invasion or metastasis.
Female
;
Humans
5.Peutz-Jeghers Syndrome with Extensive Epithelial Misplacements and Adenomatous and Carcinomatous Transformation: A case report.
Jeong Ja KWAK ; So Young JIN ; Dong Wha LEE
Korean Journal of Pathology 1993;27(6):630-637
Peutz-Jeghers syndrome is an autosomal dominant disease characterized by gastrointestinal ployposis and mucocutaneous melanin pigmentation involving the lip, oral mucosa, digits, palms and soles. The polyps are almost hamartomatous. The relationship of gastrointestinal carcinoma and the Peutz-Jeghers syndrome has been discussed for many years. The question is unsettled whether gastrointestinal carcinoma arise in hamartomatous polyps itself. Recently, there are a few reports that adenomatous and carcinomatous changes were superimposed upon the background of the hamartoma. Occasionally epithelial misplacement of the epithelium is found in the small intestinal polyps. Since the epithelial misplacement may involve submucosa, muscularis propria and serosa, a difficulty of histopathologic differential diagnosis between the epithelial misplacement and invasive adenocarcinoma cause overdiagnosis of cancer in the gastrointestinal polyps of Peutz-Jeghers syndrome. We present a case of Peutz-Jeghers syndrome of 39-year-old woman with multiple gastrointestinal polyps, two of which showed extensive epithelial misplacement even into the pancreas and another one at the colon showed carcinomatous change at the tip portion. Areas of hamartoma, adenoma and in situ carcinoma were noted in this colonic hamartomatous polyp. This case support that adenoma and carcinomatous changes may evolve directly within a hamartomaous polyp itself.
Female
;
Humans
;
Diagnosis, Differential
;
Adenocarcinoma
;
Adenoma
6.Asymptomatic uncemented total hip repalacement (changes in the femur) : Natural history determined using Tc-99m MDP bone scan (II).
Chang Dong HAN ; Jin Seok SEO ; Dong Wha LEE
The Journal of the Korean Orthopaedic Association 1993;28(2):513-526
No abstract available.
Hip*
;
Natural History*
;
Technetium Tc 99m Medronate*
7.Electron microscopic study on fine needle aspiration cytology of metastatic malignant melanoma.
Dong Wha LEE ; So Young JIN ; Kye Hyun KWON
Korean Journal of Cytopathology 1992;3(2):82-89
No abstract available.
Biopsy, Fine-Needle*
;
Melanoma*
8.Fine needle aspiration cytology of apocrine carcinoma of the breast: two cases report-.
So Young JIN ; Dong Wha LEE ; Jeong Ja KWAK
Korean Journal of Cytopathology 1992;3(2):67-74
No abstract available.
Biopsy, Fine-Needle*
;
Breast*
9.Pelvic actinomycosis: a case report.
Dae Joong KIM ; So Young JIN ; Dong Wha LEE
Korean Journal of Cytopathology 1991;2(2):172-178
No abstract available.
Actinomycosis*
10.Fine needle aspiration cytology of langerhans cell histiocytosis.
Jeong Ja KWAK ; So Young JIN ; Dong Wha LEE
Korean Journal of Cytopathology 1993;4(2):140-145
No abstract available.
Biopsy, Fine-Needle*
;
Histiocytosis, Langerhans-Cell*