No abstract available.
Tuberculosis*

No abstract available.
Asthma*

S100A6 (calcyclin) is a member of the S100 family and has been originally isolated from the cDNA library of Syrian baby hamster kidney cells. The S100A6 gene expression is reported to remain high throughout the cell cycle following induction by serum or growth factors, suggesting that the gene may be required for cell cycle progression. Nevertheless, the role that S100A6 may play in tumor progression remains unknown. In this study, we have explored the expression patterns of S100A6 gene in human thyroid tissues by northern blot analysis. Using the S100A6 monoclonal antibody, we carried out the immunohistochemical staining to determine the distribution/localization of S100A6 protein within tumor or non-tumorous cells of the thyroid. To modulate the regulation of endogenously expressed S100A6 protein in the intracellular level, overexpressed or anti-sense treated transfectant was constructed by using the eukaryotic expression vector. As a result, immunohistochemistry for S100A6 showed a strong positivity in the malignant tumors of thyroid and a high expression level of S100A6 protein affected cell proliferation in the overexpressed transfectant. These findings suggest that S100A6 may be involved in the tumor pathogenesis and provides another parameter for the differentiation of malignant and benign lesions. A well defined monoclonal antibody against S100A6 protein is now available for the immunohistochemical studies of the various thyroid tissues.
Animals ; Blotting, Northern ; Cell Cycle ; Cell Proliferation ; Cricetinae ; Gene Expression ; Gene Library ; Humans* ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins ; Kidney ; Thyroid Diseases* ; Thyroid Gland*

With the dynamically changing environment of society, managing change is the vital element of organizations's survival and growth. Health care organizations have expended enormous resources to restructure patient care delivery. Despite the growing literature describing these organizational innovations, there is a paucity of credible data that reflects systematic measurement and evaluation of such changes. This study examined the nurses' psychological response toward the work process redesign, newly introduced by the nursing department in a acute care hospital. The aim of the study was to figure out how nurses's general perception of change and perceived attributes of change affected their acceptance of change during the organizational transition. This was descriptive-correlational. The sample for the study included 50 head nurses and 135 staff nurses. Data was analyzed using SPSS PC+, version 10.0. The major findings of the study were as follows: First, the mean score of the perception of change was 71.2 (SD=13.8) with the range of 0-100, which means nurses generally perceived change positively. There were significant differences in perception of change by gender and education level. Head nurses perceived change more positively than staff nurses. The higher education level showed the more positive view of change. Second, among the perceived attributes of change, trialability had the highest mean score, which means nurses perceived the change more positively if it is testable on a limited basis. Relative advantage was perceived the most negatively. Finally, factors influencing the acceptability of the work-process redesign were perceived comparability, complexity, relative advantage, and observability, which accounted for 43.7% of the variance in the acceptability of change.This study evaluated the preliminary effects of the nursing process for reengineering, focusing on nurses' acceptability towards change. The usefulness of this research study was to determine the factors influencing acceptance of organizational members during transitional periods of change and to suggest effective strategies for increasing adoption as well as for decreasing resistance to change.
Delivery of Health Care ; Education ; Nursing ; Nursing Process ; Nursing, Supervisory ; Organizational Innovation* ; Patient Care

Bronchoalveolar lavage (BAL) has emerged as a useful technique for the study of pulmonary interstitial disorders. Several types of information are provided by the evaluation of lavage fluid. Identification of cellular constituents helps to separate inflammatory process. Recently we have studied cellular constituents of BAL from three cases with histologically confirmed pulmonary sarcoidosis, idiopathic pulmonary fibrosis and hypereosinophilic syndrome. Pulmonary sarcoidosis showed a marked increase in lymphocytes, idiopathic pulmonary fibrosis revealed a predominance of neutrophils, and hypereosinophilic syndrome presented a marked increase in eosinophils in the lavage fluids.
Bronchoalveolar Lavage ; Child* ; Eosinophils ; Humans ; Hypereosinophilic Syndrome ; Idiopathic Pulmonary Fibrosis ; Lymphocytes ; Neutrophils ; Sarcoidosis ; Sarcoidosis, Pulmonary ; Therapeutic Irrigation ; Urinary Tract Infections* ; Urinary Tract*

This study examined students' menu preferences as well as the job satisfaction and specific considerations concerning foodservice operation of dieticians and nutrition teachers at special schools for the disabled. Semi-structured interview questionnaires were sent to all of the 21 special schools with direct school food service in Gyeonggi-do, and 16 dieticians and nutrition teachers agreed to participate in this study. Among the various menu groups, the subjects perceived the meat group as the most preferred and the vegetable group the least preferred. They were generally satisfactory with their job and duty, and had a strong sense of belonging to the school. However, most of them answered that they needed more time for nutritional education and counseling. While most had pride and pleasure in their job, they expressed a desire to change the system to better fit with their roles as professional nutritionists. The content analysis revealed that the subjects mainly focused on safety issues in planning the food menu and were thus limited in selecting menu items. They also felt difficulty in menu planning due to various tastes and preferences, since special schools tend to consist of a wider grade range. However, most subjects reported little trouble in food distribution and food leftovers owing to practical support from teachers and parents. The necessity for education concerning table manners and obesity prevention was generally a shared opinion, and education programs for parents were also perceived as necessary to better understand the special considerations for developing proper eating habits in their child. The study findings provide useful basic data to improve the foodservice system at special schools.
Child ; Counseling ; Eating ; Food Services ; Humans ; Job Satisfaction ; Meat ; Menu Planning ; Obesity ; Parents ; Pleasure ; Surveys and Questionnaires ; Vegetables

PURPOSE: This study was to examine the effects of deep breathing exercises with Incentive Spirometer on the pulmonary ventilatory function of pnemothorax patients undergoing a thoracotomy. METHOD: This experiment used anonequivalent control group non-synchronized design which compared pre-experimental measures with post-experimental ones. The subjects of this study were 34 inpatients who were scheduled for a thoracotomy and classified into the experimental group (17 patients) or control group (17 patients) by using an Incentive Spirometer or not. The collected data was analyzed by a SPSS Win / PC (percentage, mean, standard deviation, chi-square test, t-test, repeated measured two-way ANOVA). RESULT: The Pulmonary Ventilatory Function of the experimental and control group were significantly increased on the first day, third day, and fifth day after the thoracotomy, but the group interaction period was not significant. CONCLUSION: This study showed that the deep breathing exercises with an Incentive Spirometer and deep breathing exercise without an Incentive Spirometer were both effective for recovering the pulmonary ventilatory function after a thoracotomy.
Thoracotomy/*rehabilitation ; Spirometry ; *Pulmonary Ventilation ; Pneumothorax/physiopathology/*surgery ; Middle Aged ; Male ; Humans ; *Breathing Exercises ; Adult

PURPOSE: This study was to examine the effects of deep breathing exercises with Incentive Spirometer on the pulmonary ventilatory function of pnemothorax patients undergoing a thoracotomy. METHOD: This experiment used anonequivalent control group non-synchronized design which compared pre-experimental measures with post-experimental ones. The subjects of this study were 34 inpatients who were scheduled for a thoracotomy and classified into the experimental group (17 patients) or control group (17 patients) by using an Incentive Spirometer or not. The collected data was analyzed by a SPSS Win / PC (percentage, mean, standard deviation, chi-square test, t-test, repeated measured two-way ANOVA). RESULT: The Pulmonary Ventilatory Function of the experimental and control group were significantly increased on the first day, third day, and fifth day after the thoracotomy, but the group interaction period was not significant. CONCLUSION: This study showed that the deep breathing exercises with an Incentive Spirometer and deep breathing exercise without an Incentive Spirometer were both effective for recovering the pulmonary ventilatory function after a thoracotomy.
Thoracotomy/*rehabilitation ; Spirometry ; *Pulmonary Ventilation ; Pneumothorax/physiopathology/*surgery ; Middle Aged ; Male ; Humans ; *Breathing Exercises ; Adult

OBJECTIVES: The purpose of this study was to evaluate the prediction validity of the caries activity test with a sulfisomidine mixture (SAHS test). METHODS: This longitudinal follow-up study was conducted for 3 years. The subjects were 155 elementary schoolchildren. Oral examination was performed by examining each tooth surface of the subjects. The number of teeth with new caries lesions was calculated by comparing between the baseline data of the initial oral examination and the results of the second oral examination performed after 3 years. The Dentocult SM test was used as the reference in the analysis of the caries prediction validity of the SAHS test. The items of the validity test for carries prediction were as follows: sensitivity, specificity, predictive value, and likelihood ratio. RESULTS: The correlation between new caries lesions and the SAHS test scores was greater than that between new caries lesions and the Dentocult SM test scores. The receiver-operating analysis revealed that the area under the curve of the SAHS test was higher than that of the Dentocult SM test. The caries prediction validity of the SAHS test (grade 12) was as follows: sensitivity, 0.71-0.70; specificity, 0.60-0.58; positive predictive value, 0.79-0.78; negative predictive value, 0.49 (screening criterion 5). The SAHS test scores were similar to or higher than the scores in the items of the Dentocult SM test. CONCLUSIONS: The SAHS test is considered useful for clinical applications.
Child ; Dental Caries ; Dental Caries Activity Tests ; Diagnosis, Oral ; Follow-Up Studies* ; Humans ; ROC Curve ; Sensitivity and Specificity ; Sulfisomidine* ; Tooth

BACKGROUND: Rocuronium has a high incidence of inducing pain by intravenous injection, and different methods have been used to minimize the incidence and severity of this pain. In this study, we have compared the effects of lidocaine and metoclopramide pretreatments on rocuronium injection pain. METHODS: Ninety healthy patients scheduled for general anesthesia were randomly divided into three groups; a saline group (n = 30), a lidocaine group (n = 30), and a metoclopramide group (n = 30). Each patient received 2 ml of pretreatment solution (normal saline, 2% lidocaine, or 0.5% metoclopramide) via an 18 G angiocatheter inserted in the antecubital fossa after applying an arm tourniquet inflated to 50 mmHg. The tourniquet was released 1 minute later, and this was followed by an intravenous injection of 0.6 mg/kg of rocuronium. General anesthesia then induced with thiopental sodium (5 mg/kg). The assessment of pain was made at the induction of anesthesia and in the recovery room, and the severity of pain was classified as none, mild, moderate, or severe by an observer. RESULTS: The severity and incidence of pain diminished significantly in the lidocaine and metoclopramide groups compared with the saline group at the induction of anesthesia (P < 0.05), but no significant difference was observed between the lidocaine and metoclopramide groups. Similar results were obtained in the recovery room; one patient in each of the saline and metoclopramide groups had no recall regarding injection pain. CONCLUSIONS: Intravenous metoclopramide pretreatment is as effective as intravenous lidocaine pretreatment for alleviating rocuronium injection pain.
Anesthesia ; Anesthesia, General ; Arm ; Humans ; Incidence ; Injections, Intravenous ; Lidocaine* ; Metoclopramide* ; Recovery Room ; Thiopental ; Tourniquets