No abstract available.
Lymphangioleiomyomatosis* ; Tuberous Sclerosis*

PURPOSE: From the early 1990s, operative mortality following pancreaticoduodenectomy have been decreased markedly. And severity of the postoperative complications also has been improved. Experienced hands in large volume hospitals and advances in supportive care have been considered as main reasons. Under this currency, indications for pancreaticoduodenectomy have been expanded, and extended pancreaticoduodenectomy has been tried more occasionally. METHODS: For 254 consecutive patients who underwent pancreaticoduodenectomy between Dec. 1998 and Mar. 2002, a retrospective analysis of operative mortality and postoperative complications was performed by reviewing of the medical records. RESULTS: Eighty-five patients were treated for common bile duct cancer, 58 patients for pancreatic cancer, 60 patients for ampulla of Vater cancer, 9 patients for duodenal cancer, 5 patients for advanced gastric cancer, 2 patient for gallbladder cancer, one patient for colon cancer and 34 patients for benign diseases or traumatic conditions. Standard pancreaticoduodecnectomies were performed in 169 patients, pylorus-preserving pancreaticoduodenectomies in 64 patients, total pancreatectomies in 15 patients and hepatopancreaticoduodenectomies in 6 patients. There was no postoperative 30-day or hospital mortality. Postoperative complications were occurred in 100 (39%) patients. The leading complication of this study is hemorrhage in 27 cases (11%) followed by pancreatic fistula in 17 cases (7%), delayed gastric emptying 16 cases (6%) and intraabdominal abscess in 11 cases (4%). There were no significant difference of the incidence of the complications between malignant diseases and benign, above 70-years old and below. Among them in 15 patients (15%) re-operative treatments were needed and in the remain conservative treatments were chosen. CONCLUSION: Operative mortality itself is no more limited factor for pancreaticoduodenectomy. Most of the complications following pancreaticoduodenectomy can be treated successfully and pancreaticoduodenectomy can be chosen as a safe and effective procedure not only in periampullary tumors but other benign diseases and even old age with same complication risk. But hemorrhagic complication and pancreatic fistula have been remained as serious problems on performing of pancreaticoduodenectomy.
Abscess ; Aged ; Ampulla of Vater ; Colonic Neoplasms ; Common Bile Duct ; Duodenal Neoplasms ; Gallbladder Neoplasms ; Gastric Emptying ; Hand ; Hemorrhage ; Hospital Mortality ; Humans ; Incidence ; Medical Records ; Mortality* ; Pancreatectomy ; Pancreatic Fistula ; Pancreatic Neoplasms ; Pancreaticoduodenectomy* ; Postoperative Complications ; Retrospective Studies ; Stomach Neoplasms

PURPOSE: Recently, hemorrhages has been accepted the most serious complication with a high mortality after a pancreaticoduodenectomy. In particular, delayed massive hemorrhages that occur from a pseudoaneurysmal rupture at the peripancreatic large arteries are quite formidable. In most patient with pseudoaneurysmal bleeding, sentinel hemorrhages can be observed. Early angiography and transcatheter arterial embolization can be used effectively as initial diagnostic and treatment modalities for a pseudoaneurysm. The authors reviewed the hemorrhagic complications from pseudoaneurysms after a pancreaticoduodenectomy and present the clinical features and treatment modalities METHODS: Four hundred-fifty-four consecutive patients who underwent a pancreaticoduodenectomy between October 1994 and April 2002 were reviewed by a retrospective evaluation of their medical records. In 8 cases with hemorrhagic complications, pseudoaneurysms were determined by angiography to be the main cause of hemorrhage. The clinical characteristics, pre-hemorrhagic symptoms, treatments and outcomes were analyzed. RESULTS: Hemorrhagic complications occurred in 35 (7.7%) out of 454 cases of pancreaticoduodenectomy. In 8 (22.8%) out of 35 cases, the hemorrhage burst from the pseudoaneurysms. In 1 out of 8 cases, the hemorrhage originated from a pseudoaneurysm on the proper hepatic artery, 1 case on the right hepatic artery, 1 case on the inferior pancreatoduodenal artery and on ligated gastroduodenal artery-stump in the remainder. Three cases had intra-abdominal complications such as a pancreatic fistula. Sentinel bleeding were observed in 7 cases, bleeding from the surgical drains in 4 cases, hematemesis in 5 cases and melena in 1 case. In all cases, arterial embolization was attempted and 6 cases were successful. Two cases required surgery. There was 1 mortality from hepatic failure after the embolization. CONCLUSION: Delayed massive hemorrhages after a pancreaticoduodenectomy should be ruled out when determining whether they are associated with an arterial pseudoaneurysmal rupture. Sentinel bleeding, which can be used as a warning sign of pseudoaneurysmal rupture, can be detected with close observation. Transcatheter arterial embolization is an effective modality to control bleeding from an arterial pseudoaneurysm initially.
Aneurysm, False* ; Angiography ; Arteries ; Hematemesis ; Hemorrhage* ; Hepatic Artery ; Humans ; Liver Failure ; Medical Records ; Melena ; Mortality ; Pancreatic Fistula ; Pancreaticoduodenectomy* ; Retrospective Studies ; Rupture

BACKGROUND/AIMS: Biliary complication after orthotopic liver transplantation(OLT) continue to be a significant cause of surgical morbidity, occurring in 10~50% of patients. Bile duct obstruction and biliary leaks account for the majority of these complications. An end-to-end choledochocholedochostomy(CD) with or without T-tube or a Roux-en-Y choledochojejunostomy(CDJ) have been the standard methods of biliary reconstruction following OLT. We reviewed our experiences of OLT to assess whether or not use of the T-tube leads to increased biliary tract complications. MATERIALS AND METHODS: From May 1996 to Feb 1998, 34 consecutive liver transplantation in 33 patients were performed at our hospital, including 12 living related liver transplantaiton. Nineteen patients were male and twenty-two patients were adult. The main indication of OLT was hepatitis B virus related cirrhosis(14 cases)in adult and biliary atresia(7 cases) in child. Four ABO incompatible cases were included in living related liver transplant. Biliary tract complications were categorized as bile leak, stenosis, or obstruction that required therapeutic intervention. Retrospective review of clinical recordings and laboratory findings were done. The median follow up periods was 10 months(range: 3~24 month). RESULTS: The methods of biliary reconstruction in cadaveric liver transplant were CD with T-tube(n=2), CD without T-tube(n=18) and Roux-en-Y HJ(n=2), respectively. In living related liver transplant(LRLT), all 12 cases were reconstructed by Roux-en-Y CDJ without stent. Biliary tract complications were observed in one case of child LRLT patient that biliary fistula occurred at exposed bile duct on cut surface of liver. This patient underwent reoperation for constructed another HJ and progressed without complication. T-tube related complication was observed in one adult patient. T-tube was impinged at cystic duct that obstructed bile flow, intermittently. This patient was treated with insertion of PTBD catheter and removal of T-tube. No other biliary complications were detected in our series. CONCLUSION: Performing an end-to-end CD without T-tube was a safe and effective method of reconstructing the biliary tract following hepatic transplantation in adult patients, comparing with T-tube splintage method. We concluded that routine placement of the T-tube at hepatic transplantation was considered to some selective cases, but more large scale and long -term studies were needed.
Adult ; Bile Ducts* ; Bile* ; Biliary Fistula ; Biliary Tract ; Cadaver ; Catheters ; Child ; Cholestasis ; Constriction, Pathologic ; Cystic Duct ; Follow-Up Studies ; Hepatitis B virus ; Humans ; Liver Transplantation* ; Liver* ; Male ; Reoperation ; Retrospective Studies ; Stents

BACKGROUND/AIMS: Biliary complication after orthotopic liver transplantation(OLT) continue to be a significant cause of surgical morbidity, occurring in 10~50% of patients. Bile duct obstruction and biliary leaks account for the majority of these complications. An end-to-end choledochocholedochostomy(CD) with or without T-tube or a Roux-en-Y choledochojejunostomy(CDJ) have been the standard methods of biliary reconstruction following OLT. We reviewed our experiences of OLT to assess whether or not use of the T-tube leads to increased biliary tract complications. MATERIALS AND METHODS: From May 1996 to Feb 1998, 34 consecutive liver transplantation in 33 patients were performed at our hospital, including 12 living related liver transplantaiton. Nineteen patients were male and twenty-two patients were adult. The main indication of OLT was hepatitis B virus related cirrhosis(14 cases)in adult and biliary atresia(7 cases) in child. Four ABO incompatible cases were included in living related liver transplant. Biliary tract complications were categorized as bile leak, stenosis, or obstruction that required therapeutic intervention. Retrospective review of clinical recordings and laboratory findings were done. The median follow up periods was 10 months(range: 3~24 month). RESULTS: The methods of biliary reconstruction in cadaveric liver transplant were CD with T-tube(n=2), CD without T-tube(n=18) and Roux-en-Y HJ(n=2), respectively. In living related liver transplant(LRLT), all 12 cases were reconstructed by Roux-en-Y CDJ without stent. Biliary tract complications were observed in one case of child LRLT patient that biliary fistula occurred at exposed bile duct on cut surface of liver. This patient underwent reoperation for constructed another HJ and progressed without complication. T-tube related complication was observed in one adult patient. T-tube was impinged at cystic duct that obstructed bile flow, intermittently. This patient was treated with insertion of PTBD catheter and removal of T-tube. No other biliary complications were detected in our series. CONCLUSION: Performing an end-to-end CD without T-tube was a safe and effective method of reconstructing the biliary tract following hepatic transplantation in adult patients, comparing with T-tube splintage method. We concluded that routine placement of the T-tube at hepatic transplantation was considered to some selective cases, but more large scale and long -term studies were needed.
Adult ; Bile Ducts* ; Bile* ; Biliary Fistula ; Biliary Tract ; Cadaver ; Catheters ; Child ; Cholestasis ; Constriction, Pathologic ; Cystic Duct ; Follow-Up Studies ; Hepatitis B virus ; Humans ; Liver Transplantation* ; Liver* ; Male ; Reoperation ; Retrospective Studies ; Stents

PURPOSE: Radiofrequency ablation (RFA) is emerging as a new therapeutic method for the management of hepatic malignancy. We report our experience on the use of his technique for the management of liver metastasis of colorectal cancer. METHODS: All 32 colorectal cancer patients with synchronous or metachronous liver metastasis treated with RFA from May 1999 to May 2001 were reviewed using retrospective method including chart review and telephone interview. All patients were followed up postoperatively to assess complications, complete necrosis, local recurrence, and survival rate. RESULTS: Forty-one RFA sessions were performed on 70 metastatic tumors in 32 patients. There were no treatment- related death. Two complications related with RFA treatment, one intrahepatic bleeding and one intrahepatic abscess, occurred in 41 sessions of RFA (6.2%). With a median follow-up of 13.5 months, tumors recurred in 7 of 70 lesions (10.0%) from 5 patients due to incomplete necrosis and intrahepatic new lesion or distant metastasis in 13 patients of 27 patients (51.9%) after complete necrosis. There were 5 deaths and the 2 year survival rate was 80.9%. Disease free survival was 90.1%, 75%, 26.4% in 6 months, 12 months and 24 months, respectively. Seven patients underwent liver resections successfully with the application of RFA for the residual lesions in the remaining contralateral lobe. In these patients, with 9.0 months median follow up, the disease recurred in 2 patients due to incomplete necrosis, while recurring in 2 patients after complete necrosis and 3 patients were survived without recurrence or distant metastasis. CONCLUSIONS: Radiofrequency ablation is a safe, well-tolerated, and effective treatment for liver metastasis in colorectal cancer patients. The procedure can be used to treat the residual tumor load in the contralateral lobe following liver resection in those considered unresectable at first presentation. This new therapeutic strategy seems to increase surgical resectability in patients whose mass is determined unresectable. To approve the efficacy of RFA, more long- term follow up should be attempted.
Abscess ; Catheter Ablation* ; Colorectal Neoplasms* ; Disease-Free Survival ; Follow-Up Studies ; Hemorrhage ; Humans ; Interviews as Topic ; Liver* ; Necrosis ; Neoplasm Metastasis* ; Neoplasm, Residual ; Recurrence ; Retrospective Studies ; Survival Rate