No abstract available.
Animals ; Carcinogenesis* ; Rats*

No abstract available.

No abstract available.

No abstract available.
Cell Line* ; Genes, Tumor Suppressor* ; Humans* ; Lung Neoplasms* ; Lung*

Serum levels of alpha-1-Antitrypsin(AAT) were determined in 42 patients with hepatocellular carcinoma(HCC), 5 patients with metastatic liver cancer from stomach adenocarcinoma, 10 patients with liver cirrhosis, 10 patients with chronic hepatitis, and 66 controls by rocket immunoelectrophoresis using rabbit antiserum. The mean level of serum AAT was 225.5 +/- 73.0 mg/dl in 66 controls. The serum AAT in patients with HCC was 428.7 +/- 123.3 mg/dl, which was significantly higher than those in the controls and in patients with liver cirrhosis or chronic hepatitis(p less than 0.02). The level of AAT in metastatic liver cancer was similar to that in HCC. The positive cut-off value for elevation of serum AAT in this study was determined as above 445 mg/dl, the mean plus 3 standard deviations in the controls. Elevations of serum AAT were observed in 54.8%, 60.0%, and 10.0% of patients with HCC, metastatic liver cancer, and liver cirrhosis, respectively, while none of the patients with chronic hepatitis or the controls was positive. The serum AAT levels in 42 patients with HCC were analyzed with regard to sex, age, serum albumin, HBsAg, alpha-fetoprotein(AFP), and diameter of HCC, with no significant differences being observed between these factors and the serum AAT levels except for the diameter of the HCC. The positive rate in the HCC with a diameter of 10 cm or more was 74.1%, which was a significantly higher rate compared with 20.0% in the HCC with diameters less than 10cm. The positive rate of AFP for HCC was 61.9%, when 500 ng/ml of AFP was used as the cut-off value.(ABSTRACT TRUNCATED AT 250 WORDS)
Adult ; Aged ; Carcinoma, Hepatocellular/blood/*diagnosis ; False Negative Reactions ; False Positive Reactions ; Female ; Humans ; Liver Neoplasms/blood/*diagnosis ; Male ; Middle Aged ; Tumor Markers, Biological/*blood ; alpha 1-Antitrypsin/*analysis

A 38-year-old man, with recurrent oral ulcers for 10 years, was admitted because of recent aggravation of odynophagia and sore throat. About 4 years earlier, he had been performed abdominal surgery for intestinal perforation. Gastrofiberscopic examination showed small round ulcers at hypiopharynx and 6cm sized longitudinal linear ulcer at mid esophagus. Biopsy specimens at mid-esophagus showed chronic inflammation. Besides oral ulcer, he had perianal ulcers and skin rashes. He was managed with steroid, colchicine and sulfasalazine under the diagnosis of esophageal involvement in Behcet's disease. After 3 months from discharge, esophagogram and gastrofiberscopic examination showed some improved appearance, but symptoms recurred for steroid tapering. He has been followed in much improved status for 8 months after discharge.
Adult ; Biopsy ; Colchicine ; Diagnosis ; Esophagus ; Exanthema ; Humans ; Inflammation ; Intestinal Perforation ; Oral Ulcer ; Pharyngitis ; Sulfasalazine ; Ulcer*

No abstract available
Adenocarcinoma* ; Humans* ; Radiation Tolerance* ; Stomach*

Although the function of most organ systems in the body decreases with age, aging has relatively little effect on the function of the gastroenterologic organs. This is probably due to the large functional reserve capacity, such as redundancy in the structure of the organ system and excessive production of hormones and enzymes. Most gastroenterologic disorders developed in younger persons may also develop in the elderly. However, the presentation, treatment and prognosis may be different between elderly patients and younger patients. One important thing is the high prevalence of certain disorders in the elderly. For example, the incidence of peptic ulcer, ischemic complications of vascular abnormalities, drug-induced disorders, malignancies, and some other disorders significantly increases with age. These disorders results either from age-determined changes in the gastroenterologic organs or from extragastroenterologic disorders, such as diabetes mellitus, neurologic diseases, and vascular changes. In this paper, an important consideration of common gastroenterologic disorders frequently developed in the Korean elderly is described. In addition, physiologic and pathologic changes of the gastroenterologic organs associated with aging are also discussed.
Aged ; *Gastrointestinal Diseases/diagnosis/epidemiology/therapy ; Humans ; Korea/epidemiology

Although the function of most organ systems in the body decreases with age, aging has relatively little effect on the function of the gastroenterologic organs. This is probably due to the large functional reserve capacity, such as redundancy in the structure of the organ system and excessive production of hormones and enzymes. Most gastroenterologic disorders developed in younger persons may also develop in the elderly. However, the presentation, treatment and prognosis may be different between elderly patients and younger patients. One important thing is the high prevalence of certain disorders in the elderly. For example, the incidence of peptic ulcer, ischemic complications of vascular abnormalities, drug-induced disorders, malignancies, and some other disorders significantly increases with age. These disorders results either from age-determined changes in the gastroenterologic organs or from extragastroenterologic disorders, such as diabetes mellitus, neurologic diseases, and vascular changes. In this paper, an important consideration of common gastroenterologic disorders frequently developed in the Korean elderly is described. In addition, physiologic and pathologic changes of the gastroenterologic organs associated with aging are also discussed.
Aged ; *Gastrointestinal Diseases/diagnosis/epidemiology/therapy ; Humans ; Korea/epidemiology

No abstract available.
HLA-DR Antigens* ; Thyroid Gland* ; Thyroid Neoplasms*