Anthracnose symptoms severely occurred up to 50% on leaves of English ivy growing in greenhouses in Cheongwon area of Korea during disease survey in April, 2000. The symptoms developed as concentric spots with dot-like acervuli on leaves of the plant. A total of 24 isolates of Colletotrichum sp. were obtained from the spotted lesions and identified as Colletotrichum trichellum based on the morphological and cultural characteristics. Leaf spots similar to the original anthracnose symptoms were induced on the host leaves by artificial inoculation with the isolates of the fungus. This is the first record of C. trichellum causing anthracnose of English ivy in Korea.
Colletotrichum* ; Cultural Characteristics ; Fungi ; Hedera* ; Korea* ; Plants

No abstract available.
Femur*

During a disease survey in October 2019, leaf spot symptoms with a yellow halo were observed on Korean angelica (Anglica gigas) plants grown in fields in Pyeongchang, Gangwon Province, Korea. Incidence of diseased leaves of the plants in the investigated fields ranged from 10% to 60%. Morphological and cultural characteristics of two single-spore isolates from the leaf lesions indicated that they belonged to the genus Didymella. Molecular phylogenetic analyses using combined sequences of LSU, ITS, TUB2, and RPB2 regions showed distinct clustering of the isolates from other Didymella species. In addition, the morphological and cultural characteristics of the isolates were somewhat different from those of closely related Didymella spp. Therefore, the novelty of the isolates was proved based on the investigations. Pathogenicity of the novel Didymella species isolates was confirmed on leaves of Korean angelica plants via artificial inoculation. This study reveals that Didymella gigantis sp. nov.causes leaf spot in Korean angelica.

During disease surveys of Angelica acutiloba plants in Korea, leaf spot symptoms were observed in a field in Andong in July 2019, and stem rot symptoms in vinyl greenhouses in Yangpyeong in April 2020. Incidence of leaf spot and stem rot of the plants ranged from 10 to 20% and 5 to 30%, respectively. Morphological and cultural characteristics of fungal iso lates from the leaf spot and stem rot symptoms fitted into those of the genus Phoma.Molecular phylogenetic analyses of two single-spore isolates from the symptoms using con catenated sequences of LSU, ITS, TUB2, and RPB2 genes authenticated an independent clus ter from other Didymella (anamorph: Phoma) species. Moreover, the isolates showed different morphological and cultural characteristics in comparison to closely related Didymella species. These discoveries confirmed the novelty of the isolates. Pathogenicity of the novel Didymella species isolates was substantiated on leaves and stems of A. acutiloba through artificial inocu lation. Thus, this study reveals that Didymella acutilobae sp. nov. causes leaf spot and stem rot in Angelica acutiloba.

In an attempt to develop a new anticancer platinum complex with greater or equivalent antitumor activity but reduced side effects compared with cisplatin (CDDP), a series of new platinum complexes having a glycolate leaving ligand was synthesized. Among them, five complexes were selected for further development on the basis of adequate water solubility, low nephrotoxicity and high antitumor activity in a murine system. The chemosensitivity of these five complexes was examined in MTT assay against two human pulmonary adenocarcinoma cell lines, PC-9 and PC-14, and two human stomach adenocarcinoma cell lines, MKN-45 and KATO III. Their IC50 and relative antitumor activity (RAA) values were compared with those of CDDP and 254-S, a second-generation platinum complex with a glycolate leaving ligand under phase III clinical trial. The lowest mean IC50 value was observed in CDDP, followed by SKI 2034R and SKI 2033R. In this study, the antitumor activity was evaluated in terms of RAA values and SKI 2034R showed the highest RAA value. The order of RAA values was SKI 2034R > CDDP > SKI 2032R > SKI 2033R > SKI 2030R > SKI 2029R > 254-S. Based on the RAA order, we have recommended SKI 2034R as the most promising candidate for further development of a clinically useful platinum complex.
Antineoplastic Agents/*pharmacology ; Cisplatin/pharmacology ; Comparative Study ; Drug Evaluation, Preclinical ; Human ; Organoplatinum Compounds/*pharmacology ; Tumor Cells, Cultured

No abstract available.
Humans ; Nephritis, Interstitial* ; Nephrotic Syndrome*

OBJECTIVE: The purpose of this study is to review the surgical results of 19 patients with idiopathic trigeminal neuralgia treated by percutaneous ballooning compression(PBC) of trigeminal gasserian ganglion under brief general anesthesia. METHODS: The mean patient age was 63.5 years(range, 27-78). The mean follow-up period was 24 months(range, 1-46). Three patients had already undergone radiofreqnency trigeminal rhizotomy and two patients had previously microvascular decompression. The balloon was inflated by injecting radio-contrast media 0.7-1cc in amount. The mean inflating time is 81 seconds(range, 60-90). RESULTS: During the procedure, brief intraoperative bradycardia and hypotension were noted in seven cases(36.7%). All patients had immediate relief of pain except 1 case. 18 cases(94.5%) of patients were satisfied or very satisfied with their pain relief. There were immediate, mild to moderate sensory complication of hypesthesia, dysesthesia or paraesthesia in all cases and the immediate motor complication-difficulty of mastication in 3 cases, transient 6th nerve palsy in 2 cases. The immediate motor and sensory complications disappeared or much improved after 3-4 months. CONCLUSION: It is the simple technique that can be performed effectively in a brief period of general anesthesia. This procedure might be one of attractive methods in the treatment of idiopathic trigeminal neuralgia.
Abducens Nerve Diseases ; Anesthesia, General ; Bradycardia ; Follow-Up Studies ; Humans ; Hypesthesia ; Hypotension ; Mastication ; Microvascular Decompression Surgery ; Paresthesia ; Rhizotomy ; Trigeminal Ganglion* ; Trigeminal Neuralgia*

Solanaceous crops grown in greenhouses and fields in Korea were surveyed from 1994 to 2000. Sclerotinia rot most severely occurred up to 60% in potato. Incidence of the disease was as high as 20% at its maximum in tomato and 5% in eggplant, but as low as less than 1% in red pepper. Symptoms of Sclerotinia rot commonly developed on stems of the solanaceous crops but rarely on fruits of eggplant and tomato. A total of 169 isolates of Sclerotinia species was obtained from the diseased solanaceous crops. Out of the isolates, 165 isolates were identified as S. sclerotiorum, and the others as S. minor based on their morphological and cultural characteristics. S. sclerotiorum was isolated from all the solanaceous crops, while S. minor was only isolated from tomato. Eight isolates of S. sclerotiorum and two isolates of S. minor were tested for their pathogenicity to the solanaceous crops by artificial inoculation. All the isolates of the two Sclerotinia spp. induced rot symptoms on stems of the solanaceous crops tested, which were similar to those observed in the fields. The pathogenicity tests revealed that there was no significant difference in the susceptibility of the solanaceous crops to the isolates of S. sclerotiorum. However, in case of S. minor, the potato cultivar Sumi was relatively less susceptible to the pathogen.
Ascomycota* ; Capsicum ; Cultural Characteristics ; Fruit ; Incidence ; Korea ; Lycopersicon esculentum ; Solanum melongena ; Solanum tuberosum ; Virulence

Anthracnose symptoms severely occurred up to 100% on leaves of May lily grown in four locations in Korea during a disease survey in 2001. The symptoms appeared as circular to irregular spots with brown to dark brown discoloration on leaves of the plant, and severely infected leaves blighted. A total of 35 isolates of Colletotrichum sp. was obtained from the spotted lesions and identified as Colletotrichum liliacearum based on the morphological and cultural characteristics. Leaf spots similar to the original anthracnose symptoms were induced on the host leaves by artificial inoculation with the isolates of the fungus. This is the first report that C. liliacearum causes anthracnose of May lily.
Colletotrichum* ; Cultural Characteristics ; Fungi ; Korea ; Lilium* ; Plants

Composite vegetable crops grown in greenhouses and open fields in Korea were surveyed from 1995 to 1999. Occurrence of Sclerotinia rot was observed in 123 of 277 lettuce fields, in 11 of 18 head lettuce fields, in 12 of 14 endive fields, and in 4 of 38 garland chrysanthemum fields surveyed during the growing seasons. The disease most severely occurred up to 80% on lettuce. Incidence of the disease was as high as 20% at its maximum on endive and garland chrysanthemum but relatively low on head lettuce. Symptoms of the disease developed on leaves of all the composites, crowns of lettuce and head lettuce, and stems of garland chrysanthemum. Out of 240 isolates of Sclerotinia species obtained from the diseased composites, 169 isolates were identified as Sclerotinia sclerotiorum, and the others as S. minor based on their morphological and cultural characteristics. S. sclerotiorum was isolated from all the composites, and S. minor only from lettuce and endive. Eight isolates of S. sclerotiorum and four isolates of S. minor were tested for their pathogenicity to the composites by artificial inoculation. All the isolates of the two Sclerotinia spp. induced rot symptoms on the plants of the composites by artificial inoculation, which were similar to those observed in the fields. The pathogenicity tests revealed that there is no significant difference in virulence of the isolates to the composites and in susceptibility of the composites to the isolates.
Ascomycota* ; Chrysanthemum ; Crowns ; Cultural Characteristics ; Head ; Incidence ; Korea ; Lettuce ; Seasons ; Vegetables* ; Virulence