Objective To investigate the value of conventional ultrasound and CEUS in the diagnosis of peripheral lung lesions.Methods Totally 120 patients with peripheral lung lesions found with chest CT were enrolled.Conventional ultrasound and CEUS were performed.The site,size,shape,echo and blood flow signals,as well as the adjacent tissue of lesions were evaluated with conventional ultrasonography.Then,the contrast enhancement pattern,degree and uniformity of lesions were observed with CEUS,and the time-intensity curve analysis was performed to obtain the relevant parameters,including the rise time (RT),peak intensity (PI),mean transit time (MTT),area under the curve (AUC),half washout time (TPH),clearance time and descending slope (DS).The above parameters of benign and malignant lesions were statistically analyzed.Results Among 120 cases,there were 52 benign and 68 malignant tumors.Statistically significant differences were found in morphological comparison between benign and malignant lesions (P＜0.05),while benign lesions were more multi wedge-shaped or triangular shape,and malignant lesions were more round or irregular shape.RT,DS and clearance time of benign and malignant lesions were statistically different (all P＜0.001),but there was no significant difference in PI,MTT,AUC and TPH (all P＞0.05).Conclusion Conventional ultrasound and CEUS can provide important information for diagnosis of peripheral lung lesions.

BACKGROUND:Autophagy has become a rapidly developing research hotspot in the biomedical fields.Many researchers are actively exploring the molecular regulatory mechanism of autophagy in a variety of diseases.However,the role of autophagy in hair growth is still unknown. OBJECTIVE:To review the current research progress and application value of autophagy in hair growth and regeneration,to understand the role of autophagy in hair growth,to explore the pathogenesis of autophagy in pathological hair loss,and to provide new ideas for the study of drugs for hair loss. METHODS:Using"hair follicle growth,hair growth,hair regeneration,autophagy associated proteins,autophagy activity,autophagy associated genes,autophagy"as Chinese search terms and"hair growth,hair follicle,hair regeneration,autophagy"as English search terms,PubMed and CNKI databases were searched.The research progress on autophagy,hair growth and the role of autophagy in hair growth in and outside China in recent years was reviewed and summarized.Articles incompatible with the subject content of the paper were excluded.Finally,78 articles were included for the result analysis. RESULTS AND CONCLUSION:(1)Autophagy is a normal metabolic process in eukaryotes with complex molecular mechanisms and functional properties,which is beneficial to cell survival and cell death.(2)Alopecia-related diseases are associated with changes in autophagy activity,which can regulate hair growth cycle.Knockout or overexpression of autophagy-related genes can change the state of hair growth.Multiple autophagy related signaling pathways have been found to be related to hair follicle growth.Activators or inhibitors of autophagy can be used to treat or prevent hair loss.