Objective To investigate the prevalence of depression in children with type 1 diabetes (T1DM) and analysis its risk factors. Methods A total of 225 children with T1DM were divided into 2 groups according to BDI score:T1DM+depression group (n=123,BDI>10) and T1DM group (n=102,BDI≤10).Then,the subjects in T1DM+depression group were divided into mild depression subgroup (n=42,102 times/d were higher in T1DM+depression group than in T1DM group(P<0.05 or P<0.01).(2) Age,BMI,FPG,HbA1c,insulin doses and ratio of insulin injection>2 times/d were higher in severe depression subgroup than in mild subgroup and medium subgroup,DM course and ratio of insulin injection≤2 times/d were lower in severe depression subgroup than in mild subgroup (P<0.05 or P<0.01).(3) Multiple stepwise regression analysis showed that age,DM course,FPG,HbA1c,incidence of DKA and hypoglycemia,insulin doses and insulin injection>2 times/d were the influencing factors for BDI levels.Logistic regression analysis showed that girl,long DM course,insulin injection>2 times/d,high HbA1c,high incidence of DKA and hypoglycemia were risk factors for depression in T1DM children (P<0.05). Conclusion The higher occurrence of depression in T1DM children indicates that early screening and intervention is necessary.Children with risk factors should be given more psychological care to prevent the occurrence of depression.

Objective To explore the influence of long-term inhaled corticosteroids on insulin-like growth factor-1(IGF-1),bone mineral density, height and weight in children with bronchial asthma.Methods Bronchial asthma were selected as treatment group from January 2013 to January 2014 in pediatrics department of Nanyang Central Hospital, and 25 healthy children undergoing physical examination at the same time were selected as control group.All children aged from 4 to 5 years old.The treatment group received nebulized budesonide suspension, 250-1 000μg per time, two times per day and 10-15 min per time for a maintenance therapy of 12 months.The control group were without any treatment.The changes of IGF-1 and bone mineral density were compared among pre-treatment, 6 months and 12 months post-treatment in treatment group and the changes of height and weight were compared between two groups.Results There were no significant differences in levels of serum IGF-1 and bone mineral density among pre-treatment, 6 months and 12 months post-treatment in treatment group (F =0.259,F =0.217, all P>0.05).There were no significant differences in height and weight between two groups pre-treatment, 6 months and 12 months post-treatment.Conclusion Long-term inhaled corticosteroids has no significant effect on growth indicators in children aged 4-5 years old with bronchial asthma.

OBJECTIVEThe relationship between polymorphisms of ALAD and VDR genes and individual susceptibility of lead poisoning was investigated in children highly-exposed to lead.

METHODFour hundred and sixty-nine children were recruited into this study and the blood lead, ZPP, hemoglobin as well as three physical developmental indexes (head circumference, height and weight) were measured. VDR and ALAD gene polymorphisms were analyzed by the methods of PCR-RFLP.

RESULTSThe subjects with ALAD2 allele had higher ZPP level (10.12 micro mol/L vs 12.87 micro mol/L) (P = 0.017). The subjects with B allele has larger head circumference than only with b allele (51.19 cm vs 50.75 cm) (P = 0.028).

CONCLUSIONSIt was suggested that the ALAD gene polymorphism modified the relationship between blood lead and ZPP and the VDR gene variants influenced the skull development in children living under lead-polluted environment. The polymorphism of ALAD and VDR genes might serve as the molecular inherited factors modifying the susceptibility of lead poisoning.

Alleles ; Body Height ; drug effects ; genetics ; Body Weight ; drug effects ; genetics ; Child ; China ; epidemiology ; Environmental Pollution ; adverse effects ; Female ; Gene Frequency ; Genotype ; Humans ; Lead ; adverse effects ; blood ; Lead Poisoning ; epidemiology ; etiology ; genetics ; Male ; Polymorphism, Genetic ; Porphobilinogen Synthase ; genetics ; Receptors, Calcitriol ; genetics