1.Determination of the Content or Four Active Factors of Vitamine E in Oil of Running Mallow(Malva rotundifolia)
Chinese Traditional and Herbal Drugs 1994;0(04):-
Analysis and determination of the content of four active factors of Vitamin E in Malva rotundifolia oilwere carried out by normal and reverse phase HPLC. The retention mechanism on the normal and reversephase columns of the four active factors was studied.
2.Disease burden of stroke
International Journal of Cerebrovascular Diseases 2013;21(12):913-917
Stroke is a type of neurological disease with high morbidity,disability,and mortality.It has become a global public health problem.At present,the stroke burden in countries around the world has shown an upward trend.This article reviews the extent of population health hazards caused by stroke,as well as the evaluation of economic burden of the disease.
3.Exploration and efficacy assessment of the model for epilepsy management in rural China
Xiaowei WANG ; Xiaojuan RU ; Wenzhi WANG
Chinese Journal of Neurology 2016;49(5):358-363
Objective To evaluate the applicability and effectiveness of the model for managing patients with convulsive epilepsy in rural China.Methods The model is under leadership of the government departments and medical institutions at all levels organized primary physicians for treatment and management.People with convulsive epilepsy in 24 rural areas were screened by local physicians and confirmed by neurologists.Patients diagnosed with convulsive epilepsy and agreed with managing were recruited into study.They were managed at primary care level and provided with phenobarbital monotherapy.Efficacy was assessed from the changes in seizure frequencies from baseline.Results There were 408 town hospitals and 979 trained primary care physicians participating in our study.Five thousand and thirty-eight patients were enrolled in 2 years,and 90% patients with good compliance.Among the people who were treated with phenobarbital monotherapy,3 170 were managed for 12 months,and 2 005 (63.3%) of whom had a 50% or greater reduction in seizure frequency and 1 246 (39.3%)patients remained seizure free;651 patients were managed for 24 months,and 491 (75.4%) of whom had a 50% or greater reduction in seizure frequency and 202(31.0%)patients remained seizure free.Three hundred and forty-three (6.8%) patients withdrew from the study,and only 35 (0.7%) patients discontinued treatment because of side effects.Sixty-nine (1.4%) patients were dead and 8 (11.6%) of them were caused by status epilepticus.Conclusion This study confirms that this model is beneficial to patients with epilepsy and is suitable to the rural areas of China.
4.Advances of GOLPH2 in tumors
Wenzhi LI ; Xiang WANG ; Gang CHEN
Journal of International Oncology 2013;(2):89-92
As a novel Golgi protein,GOLPH2 expression is associated with maintaining the structural integrity of the Golgi apparatus.As an oncoprotein,GOLPH2 expression is associated with malignant biological behavior of cancer cells.Important roles of GOLPH2 in the tumorigenesis and metastasis make it become a new target for tumor diagnosis and treatment.
5.Prospect for research on anti-angiogenesis drugs for breast cancer
Wenzhi LIU ; Xiaoyan WANG ; Mengkao LI
Journal of International Oncology 2010;37(6):442-444
It has recently been demonstrated that anti-angiogenesis drugs targeting every possible aspect of tumor angiogenesis effectively inhibit the growth, invasion and metastasis of breast cancer with low sideeffects and drug resistance. These types of anti-angiogenesis drugs have become a hotspot in the field of breast cancer research.
6.Global Campaign Against Epilepsy: An update on the China Demonstration Project and Crest Study
Shichuo Li ; Jianzhong Wu ; Wenzhi Wang
Neurology Asia 2007;12(Supplement 1):44-45
Global Campaign Against Epilepsy conducted the Demonstration Project to improve epilepsy care in
rural China from 2000 to 2004. The project involved 5 provinces and 2,455 patients with convulsive
epilepsy using phenobarbital monotherapy. Forty percent of the patients were seizure free in one year
and another 30% had their seizures decreased by over half. With the support of the central government,
the project has currently been extended to cover 12 provinces with 11,000 patients. The long-term plan
is to integrate epilepsy management into the existing primary health delivery system of China.
7.Automatic drawing on target therapy area in HIFU treatment based on MRI and CT imagings
Haiyan WEN ; Wenzhi CHEN ; Zhibiao WANG
Journal of Third Military Medical University 2003;0(21):-
Objective To study automatic drawing on target therapy area based on MRI and CT imagings in order to get the precision less than 1 mm in HIFU treatment.Methods Based on MRI and CT imagings,automatic image was recognized and the frame was extracted by image processing and image segmentation,etc..Results The system of software we are studying can be effectively used to recognize medical automatic images and get target therapy areas' image drawings.Conclusion This system of software will be used in medical precise treatment systems,such as HIFU 3D Treatment Regional Planning System.
8.Characteristics of hysteromyoma MRI images
Haiyan WEN ; Wenzhi CHEN ; Zhibiao WANG
Journal of Third Military Medical University 2002;0(12):-
Objective To study the common imaging characters of the human tissues such as tumors in MRI based on hysteromyoma in hope of getting the results that the same tissue has the same MR characters and identifying the common,comparatively steady MR figs sectional area which can provide related references for the computer-based automatic recognition orgnization and basis for the question such as whether the same MR figs has the same hyperacoustic impedance characters.Methods We analysed all the images with hysteromyoma on MRI T2 and got the rules on MR figs change with the application of the MRI image analysing software which specially designed by Microsoft Visual C++ 6.0 for the research.Results(1)No significant difference was found in MR figs sectional area in the different periods of the same patient under the same MRI test condition.(2)No significant difference was found in MR figs sectional area in different patients under the same MRI test condition.(3)Significant difference was found in MR figs sectional area after the patient received the HIFU treatment under the same MRI test condition.Conclusion(1)Human tissues have some common MRI imaging characters in the same MRI test equipment under the same MRI test condition.(2)Imaging characters of the human body tissues in MRI can be altered after HIFU treatment.
9.Use of first metatarsal neck osteotomy and inverted impaction fixation to correct symptomatic hallux valgus
Huimin WANG ; Mingsheng TAN ; Wenzhi CHEN
Orthopedic Journal of China 2006;0(01):-
[Objective]To assess the success of hallux valgus surgery of oblique and impaction osteotomy of first metatarsal neck.[Method]The outcome of 36 patients(45 feet)treated by this technique for symptomatic hallux valgus deformity was reviewed.The follow-up was two years.Lateral and AP radiographs were taken in a standing position pre-and postoperativly and hallux valgus angle(HV angle)and intermetatarsal angle(IM 1~2 angle)were measured accordingly.The efficacy of the surgery was evaluated by JOA scoring for foot disorders.[Result]The fracture healing was excellent.There was no case of delay union and nonunion.Two cases(three feet)were found to have superficial infection.The mean HV angle and IM 1~2 angle was revised by 15.6? and 4.2? respectively.JOA score was elevated for 29.6 points.[Conclusion]Hallux valgus can be corrected in three-dimension by the technique of first metatarsal neck osteotomy and inverted impaction fixation.
10.Advances in Studying the Differentiation of Bone Marrow Mesenchymal Stem Cells into Neurons
Ning REN ; Xinping WANG ; Wenzhi ZHANG
International Journal of Cerebrovascular Diseases 2006;0(01):-
Bone marrow mesenchymal stem cells(BMSCs) are a population of multipotent cells. Many researchers have studied whether BMSCs could differentiate into neurons in vivo and ex vivo. Although some studies didn't agree with about some chemical induction medium inducing neurons, the application of cell transplantion and gene therapy of BMSCs has achieved certain progress showing good future for BMSCs in therapy of nervous system diseases.